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Mechanisms of Heart Disease Caused by LMNA Mutations and Potential Therapeutic Applications

In eukaryotes, the nuclear envelope regulates nuclear functions by enclosing chromatin higher-order structures. Genetic mutations in nuclear membrane-associated proteins lead to intractable diseases known as nuclear envelopathies. This symposium will focus on the life phenomena related to these diseases, such as metabolic regulation, inflammatory reaction and immune response, to present the frontiers of nuclear envelope biology, which are conducted by cross-sectional studies including molecular structure analysis, image analysis, bioinformatics and clinical specimen analysis. The discussion will revolve around the latest findings, emphasizing the basic structure and functions of the nuclear envelope.<br>

【J】The origin of nuclear envelope biology and the new challenges: The basis of the nuclear envelope provides insights into life phenomena and diseases

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[3MS-04-03]Mechanisms of Heart Disease Caused by LMNA Mutations and Potential Therapeutic Applications

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