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RNA polymerase II-mediated rDNA transcription is necessary for rDNA copy number expansion in Drosophila

Recently, various noncoding RNAs have been recognized to be synthesized from dispersed junk repeat regions in the genome, suggesting their potential for playing crucial regulatory roles. Concurrently, these repeat regions can induce genomic mutations as mobile elements and disrupt gene expression. Cells have developed sophisticated RNA-based inhibitory mechanisms to suppress the harmful effects of these regions. This symposium focuses on the intricate mechanisms involved in the tug-of-war related to junk regions in the genome, examining the production of noncoding RNAs as a driving force for the functional expansion of genomes.<br>

【E】Manifestation of junk DNA functionality through noncoding RNA expression and its inhibition mechanisms

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[3PS-01-04]RNA polymerase II-mediated rDNA transcription is necessary for rDNA copy number expansion in Drosophila

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