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Embryo-specific DNA replication program is associated with genome instability in mice

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Most normal cells are diploid in their ploidy, but modified or dysregulated cell cycle control often leads to ploidy alterations, including polyploidy and aneuploidy. Such ploidy alterations contribute to different types of cell diversification, such as senescence, differentiation, or tumorigenesis. Understanding the causes and consequences of ploidy alterations has become an important subject in broad research areas. In this symposium, we aim to understand the latest insights into the processes and principles of ploidy alterations in various biological contexts, discussing their significance from the cellular to the organism level.<br>

The 47th Annual Meeting of the Molecular Biology Society of Japan

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[3PS-08-03]Embryo-specific DNA replication program is associated with genome instability in mice

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