[3PS-08] 【E】Causes and consequences of ploidy alterations | The 47th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Open-call Symposium : [3PS-08] Causes and consequences of ploidy alterations

[3PS-08]【E】Causes and consequences of ploidy alterations

Fri. Nov 29, 2024 4:45 PM - 7:00 PM JST
Fri. Nov 29, 2024 7:45 AM - 10:00 AM UTC

Room 8(Fukuoka International Congress Center, 4F 414)

Organizer: Minji Jo (Cancer Institute, Japanese Foundation For Cancer Research), Ryota Uehara (Faculty of Advanced Life Science, Hokkaido University)

Most normal cells are diploid in their ploidy, but modified or dysregulated cell cycle control often leads to ploidy alterations, including polyploidy and aneuploidy. Such ploidy alterations contribute to different types of cell diversification, such as senescence, differentiation, or tumorigenesis. Understanding the causes and consequences of ploidy alterations has become an important subject in broad research areas. In this symposium, we aim to understand the latest insights into the processes and principles of ploidy alterations in various biological contexts, discussing their significance from the cellular to the organism level.

4:45 PM - 4:47 PM JST(7:45 AM - 7:47 AM UTC)

Introduction

4:47 PM - 5:04 PM JST(7:47 AM - 8:04 AM UTC)

[3PS-08-01]Determinants of cellular fates and characteristics after whole-genome duplication

○Ryota Uehara¹, Masaya Inoko¹, Guang Yang¹ (1. Hokkaido University)

Comment()

5:04 PM - 5:29 PM JST(8:04 AM - 8:29 AM UTC)

[3PS-08-02]Causes and consequences of aneuploidy in cancer

○Sarah McClelland¹, Nadeem Shaikh¹, Molly Guscott¹, Sarah Johnson¹, Laura Tovini¹, Alice Mazzagatti¹ (1. Barts Cancer Institute, Queen Mary University of London)

Comment()

5:29 PM - 5:47 PM JST(8:29 AM - 8:47 AM UTC)

[3PS-08-03]Embryo-specific DNA replication program is associated with genome instability in mice

○Saori Takahashi¹, Hirohisa Kyogoku^1,2, Takuya Hayakawa³, Hisashi Miura¹, Asami Oji¹, Yoshiko Kondo¹, Shin-ichiro Takebayashi³, Tomoya S. Kitajima¹, Ichiro Hiratani¹ (1. RIKEN, 2. Kobe Univ., 3. Mie Univ.)

Comment()

5:47 PM - 6:00 PM JST(8:47 AM - 9:00 AM UTC)

[3PS-08-04(3P-610)]Analysis of mammalian ploidy characteristics using multiple polyploidized mouse embryos.

○Hiroyuki Imai¹, Sumito Matsuya^2,3, Kaoru Fujino², Muneyoshi Hyoto¹, Kiyoshi Kano², Takeshi Ken Kusakabe¹ (1. Lab. of Vet. Anat., Yamaguchi University, 2. Lab. of Dev. Genet., Yamaguchi University, 3. Lab. of Vet. Anat., Kagoshima University)

Comment()

6:00 PM - 6:25 PM JST(9:00 AM - 9:25 AM UTC)

[3PS-08-05]Causes and Consequences of Aneuploidy in Human Pluripotent Stem Cells

Chenhui Deng^1,2, Brian Galaviz Sarmiento^1,2, Amanda Ya^1,2, Duane Compton^1,2, ○Kristina M Godek^1,2 (1. Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA , 2. Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA)

Comment()

6:25 PM - 6:43 PM JST(9:25 AM - 9:43 AM UTC)

[3PS-08-06]Modeling polyploid cancer cells in Drosophila

○Yoichiro Tamori¹ (1. Kyoto University)

Comment()

6:43 PM - 7:00 PM JST(9:43 AM - 10:00 AM UTC)

[3PS-08-07]Plastic nature of Aurora B kinase and its effects on aneuploid cancer stem cells

○Minji Jo¹, Oltea Sampetrean², Tetsuya Negoto³, Utako Kato¹, Hideyuki Saya⁴, Toru Hirota¹ (1. Cancer Institute, Japanese Foundation for Cancer Research, 2. Human Biology-Microbiome-Quantum Res. Ctr., Keio Univ., 3. Dept. Neurosurg., Sch. Med., Kurume Univ., 4. Oncology Innovation Ctr., Fujita Health Univ.)

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