The 47th Annual Meeting of the Molecular Biology Society of Japan
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Open-call Symposium : [1AS-02] Aging and Pathology Induced by Genome Stress and Metabolic Aberrations

[1AS-02]【J】Aging and Pathology Induced by Genome Stress and Metabolic Aberrations

Wed. Nov 27, 2024 9:00 AM - 11:15 AM JST
Wed. Nov 27, 2024 12:00 AM - 2:15 AM UTC
Room 2(Fukuoka International Congress Center, 5F 502+503)
Organizer: Atsushi Shibata (Keio University), Akiko Takahashi (The Cancer Institute of Japanese Foundation for Cancer Research )
Living organisms maintain homeostasis by appropriate cellular responses to a various type of stresses. In particular, because stress response abnormalities arising from the genome and metabolism causes aging and cancer, elucidation of the molecular mechanisms is required. This symposium will gather researchers in various fields such as cancer, aging, DNA repair, immunity, metabolism, and epigenome to discuss for overcoming pathological conditions on aging and cancer.
9:00 AM - 9:03 AM JST(12:00 AM - 12:03 AM UTC)

Introduction

9:03 AM - 9:21 AM JST(12:03 AM - 12:21 AM UTC)

[1AS-02-01]Regulation of chromatin structure and remodeling to promote DNA double-strand break repair

○Atsushi Shibata1 (1. Keio Univ.)
Comment()
9:21 AM - 9:34 AM JST(12:21 AM - 12:34 AM UTC)

[1AS-02-02(1P-068)]When Base Excision Repair goes wrong - Chromosome fragmentation due to TORC2 inhibition depends on nuclear actin-dependent remodeler activity

○Susan M Gasser1, Kenji Shimada2, Verena Hurst2, Christian B Gerhold2, Cleo V.D. Tarashev2, Masahiko Harata3, Barbara van Loon4 (1. ISREC Foundation and University of Lausanne, 2. FMI, Basel, 3. Tohoku University, Sendai, 4. Norwegian University of Science and Technology)
Comment()
9:34 AM - 9:47 AM JST(12:34 AM - 12:47 AM UTC)

[1AS-02-03(1P-745)]Nucleolar abnormalities induce the formation of XPG-dependent RNA-DNA hybrids, contributing to the pathogenesis of ribosomopathies through the priming of innate immune response

○Ken Takashima1, Hiroyuki Oshiumi1 (1. Kumamoto university)
Comment()
9:47 AM - 10:00 AM JST(12:47 AM - 1:00 AM UTC)

[1AS-02-04(1P-017)]R-loop regulation by RNA-dependent RNA polymerase activity

○Mitsuhiro Machitani1, Akira Nomura1,2, Kenkichi Masutomi1 (1. Div. Cancer Stem Cell, Natl. Cancer Ctr. Res. Inst., 2. Dep. Orthopedic Surg., Tokai Univ. Sch. Med.)
Comment()
10:00 AM - 10:13 AM JST(1:00 AM - 1:13 AM UTC)

[1AS-02-05(1P-785)]Non-senolytic actions of Dasatinib and Quercetin (D+Q) on senescent cells

○Koyu Ito1, Masahiro Wakita1, Birte Kristin Jung1, Eiji Hara1 (1. Osaka University)
Comment()
10:13 AM - 10:33 AM JST(1:13 AM - 1:33 AM UTC)

[1AS-02-06]The Rubicon-WIPI axis regulates exosome biogenesis during aging

○Kyosuke Yanagawa1,2, Akiko Kuma1,3, Maho Hamasaki1,4, Shunbun Kita5,6, Tadashi Yamamuro7, Kohei Nishino8, Shuhei Nakamura9, Hiroko Omori10, Tatsuya Kaminishi1,11, Satoshi Oikawa7, Yoshio Kato12, Ryuya Edahiro13,14, Ryosuke Kawagoe15, Takako Taniguchi15, Yoko Tanaka16, Takayuki Shima9, Keisuke Tabata17, Miki Iwatani1, Nao Bekku1, Rikinari Hanayama18,19, Yukinori Okada13,20,21,22,23, Takayuki Akimoto24, Hidetaka Kosako8, Akiko Takahashi16, Iichiro Shimomura5, Yasushi Sakata2, Tamotsu Yoshimori1,3,4,11 (1. Department of Genetics, Graduate School of Medicine, Osaka University, 2. Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University, 3. Health Promotion System Science, Graduate School of Medicine, Osaka University, 4. Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences Osaka University, Osaka University, 5. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 6. Tokyo New Drug Research Laboratories, Pharmaceutical Business Unit, Kowa Company Ltd, 7. Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, 8. Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, 9. Department of Biochemistry, Nara Medical University, 10. Research Institute for Microbial Diseases, Osaka University, 11. Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 12. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 13. Department of Statistical Genetics, Osaka University Graduate School of Medicine, 14. Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, 15. i2i-Labo, Central Pharmaceutical Research Institute Yokohama Research Center, JT inc., 16. Division of Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, 17. Department of Physiology, Juntendo University School of Medicine , 18. Department of Immunology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, 19. WPI Nano Life Science Institute (NanoLSI), Kanazawa University, 20. Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, 21. Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, 22. Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, 23. Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, 24. Laboratory of Muscle Biology, Faculty of Sport Sciences, Waseda University)
Comment()
10:33 AM - 10:53 AM JST(1:33 AM - 1:53 AM UTC)

[1AS-02-07]Excess iron stress and tumor progression

○Toshiro Moroishi1 (1. Kumamoto Univ.)
Comment()
10:53 AM - 11:13 AM JST(1:53 AM - 2:13 AM UTC)

[1AS-02-08]Analysis of Biological Functions of Cellular Senescence Induced by Stress

○Akiko Takahashi1 (1. Japanese Foundation for Cancer Research)
Comment()
11:13 AM - 11:15 AM JST(2:13 AM - 2:15 AM UTC)

Conclusion

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