Session Details
[1PS-08]【J】Epigenome dynamics in cell fate determination
Wed. Nov 27, 2024 4:45 PM - 7:00 PM JST
Wed. Nov 27, 2024 7:45 AM - 10:00 AM UTC
Wed. Nov 27, 2024 7:45 AM - 10:00 AM UTC
Room 8(Fukuoka International Congress Center, 4F 414)
Organizer: Hiroki Sugishita (The University of Tokyo), Shinsuke Ito (RIKEN)
The expression of several thousand developmental genes is regulated in a spatio-temporal manner during development. To differentiate into a specific lineage, it is necessary to regulate the expression of genes involved in lineage commitment. However, it is not clear how such gene regulation is established. In this symposium, we will focus on how epigenomes at critical genes involved in development and differentiation are established and maintained, and we will present and discuss the latest research findings.
Introduction
[1PS-08-01]Dynamics of the tissue- and stage-specific enhancer formation by Polycomb repressive complexes
○Hiroki Sugishita1,2, Kazunori Hojo2, Yukiko Gotoh1,2 (1. WPI-IRCN, The University of Tokyo, 2. Graduate School of Pharmaceutical Sciences, The University of Tokyo)
[1PS-08-02(1P-095)]Elucidation of the transcriptional regulatory mechanisms by single-cell multi-epigenomics
○Takeru Fujii1, Akihito Harada1, Kazumitsu Maehara1, Hiroshi Kimura2, Yasuyuki Ohkawa1 (1. Medical Institute of Bioregulation, Kyushu University, 2. Institute of Innovative Research, Tokyo Institute of Technology)
[1PS-08-03]Spatial chromatin organization in brain development
○Yuki Fujita1 (1. Shimane University)
[1PS-08-04(1P-111)]The function of active histone modifications during zygotic genome activation in fish embryos
○Hiroto S Fukushima1,2, Hiroyuki Takeda2,3 (1. RIKEN IMS, 2. The Univ. of Tokyo, 3. Kyoto Sangyo University)
[1PS-08-05]Development and Application of the High-Resolution Spatial Transcriptome Method Photo-Isolation Chemistry (PIC)
○Mizuki Honda1 (1. Hiroshima University)
[1PS-08-06]Role of the polycomb repressive complex PCGF1-PRC1 in the transcriptional acitivation during cell differentiation
○Shinsuke Ito1, Takashi Kondo1, Junichiro Takano1, Marika Shibata1, Kaori Kondo1, Mio Harachi1, Haruhiko Koseki1 (1. RIKEN IMS)
[1PS-08-07]Neuron-specific alternative splicing of chromatin regulators
○Shigeki Iwase1 (1. University of Michigan, Nichigan Medicine, Department of Human Genetics)
[1PS-08-08]Preventing CpG hypermethylation in oocytes safeguards mouse development
○Yumiko Kawamura2,1, Evgeniy A Ozonov2, Panagiotis Papasaikas2, Takashi Kondo4, Nhuong V Nguyen2, Michael B Stadler2,3, Sebastien A Smallwood2, Haruhiko Koseki4, Antoine H.F.M Peters2,3 (1. Aarhus University, 2. Friedrich Miescher Institute, 3. University of Basel, 4. RIKEN Center for Integrative Medical Sciences (IMS))
[1PS-08-09]HMGA2 directly mediates chromatin condensation in association with neuronal fate regulation
○Naohiro Kuwayama1,2, Tomoya Kujirai3, Yusuke Kishi3, Rina Hirano3, Kenta Echigoya3, Lingyan Fang1, Sugiko Watanabe4, Mitsuyoshi Nakao4, Yutaka Suzuki5, Kei-ichiro Ishiguro4, Hitoshi Kurumizaka3, Yukiko Gotoh1,6 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Department of Molecular and Cell Biology, University of California, Berkeley, 3. Institute for Quantitative Biosciences, The University of Tokyo, 4. Institute of Molecular Embryology and Genetics, Kumamoto University, 5. Department of Computational Biology, Graduate School of Frontier Sciences, 6. International Research Center for Neurointelligence (WPI-IRCN))