The 47th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Open-call Symposium : [2AS-11] The dynamic interplay between three-dimensional chromosome structure and gene regulation

[2AS-11]【E】The dynamic interplay between three-dimensional chromosome structure and gene regulation

Thu. Nov 28, 2024 9:00 AM - 11:15 AM JST
Thu. Nov 28, 2024 12:00 AM - 2:15 AM UTC
Room 11(Fukuoka International Congress Center, 2F 202)
Organizer: Kristian Jeppson (The University of Tokyo), Takashi Fukaya (The University of Tokyo)
Chromosomes are organized in three-dimensional space to allow the proper expression and duplication of the genetic material. By introducing new insights from cutting-edge techniques such as genome-wide analyses, quantitative live-imaging and single-molecule analyses, this symposium aims to shed light on mechanisms controlling three-dimensional chromosome structure and gene regulation, and how these processes intersect.
9:00 AM - 9:04 AM JST(12:00 AM - 12:04 AM UTC)

Introduction

9:04 AM - 9:20 AM JST(12:04 AM - 12:20 AM UTC)

[2AS-11-01]Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils

○Kristian Jeppsson1,2, Biswajit Pradhan3, Takashi Sutani1, Toyonori Sakata1,2, Miki Umeda Igarashi1, Davide Giorgio Berta2, Takaharu Kanno2, Ryuichiro Nakato1, Katsuhiko Shirahige1, Eugene Kim3, Camilla Bjorkegren2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan, 2. Karolinska Institutet, Department of Cell and Molecular Biology, Biomedicum, Tomtebodavagen 16, 171 77 Stockholm, Sweden, 3. Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany)
Comment()
9:20 AM - 9:36 AM JST(12:20 AM - 12:36 AM UTC)

[2AS-11-02]Mechanistic insights into STAG mediated DNA loading in cohesin complexes.

○Yoshimi Kinoshita1, Ryota Sakata1, Tomoko Nishiyama1 (1. Kyoto University)
Comment()
9:36 AM - 9:52 AM JST(12:36 AM - 12:52 AM UTC)

[2AS-11-03]MukBEF ensures proper chromosome segregation of highly transcribed regions

○Andres Canela1, Nadim Majdalani2, Naohiro Osada1, Francine Lianne Emralino1, Shar-yin N Huang3, Jun Nakamura4, Takemata Naomichi5 (1. Radiation Biology Center, Graduate School of Biostudies, Kyoto University, 2. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 3. Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, 4. School of Veterinary Medicine, Osaka Metropolitan University,, 5. Graduate School of Engineering, Kyoto University)
Comment()
9:52 AM - 10:08 AM JST(12:52 AM - 1:08 AM UTC)

[2AS-11-04]Transcription near arrested DNA replication forks triggers ribosomal DNA instability

○Mariko Sasaki1 (1. National Institute of Genetics)
Comment()
10:08 AM - 10:24 AM JST(1:08 AM - 1:24 AM UTC)

[2AS-11-05]How MYC modulates TOP2A diffusion to regulate activity – the tip of the iceberg?

○Donald Cameron1,2, Kathryn Jackson2, Carl Ivar Möller3, Evanthia Iliopoulou2, Matteo Mazzocca4, Alessia Loffreda4, Evgeniya Pavlova3, Fredrik Westerlund3, Davide Mazza4, Laura Baranello2 (1. Institute for Quantitative Biosciences, University of Tokyo, 2. Karolinska Institute, Stockholm, Sweden, 3. Chalmers University of Technology, Gothenburg, Sweden, 4. Ospedale San Raffaele, Milan, Italy)
Comment()
10:24 AM - 10:40 AM JST(1:24 AM - 1:40 AM UTC)

[2AS-11-06(2P-359)]Spatial regulation of ribosomal RNA transcription by phase separation and transition

○Satoru Ide1, Yasuto Murayama2,3, Kazuhiro Maeshima2,3 (1. Tokyo Metropolitan Institute of Medical Science, 2. National Institute of Genetics, 3. SOKENDAI)
Comment()
10:40 AM - 10:56 AM JST(1:40 AM - 1:56 AM UTC)

[2AS-11-07]To build and visualize chromatin: understanding epigenetic regulation

○Minhee Park1 (1. KAIST)
Comment()
10:56 AM - 11:12 AM JST(1:56 AM - 2:12 AM UTC)

[2AS-11-08]Transcription dynamics in living embryos

○Takashi Fukaya1 (1. The University of Tokyo)
Comment()
11:12 AM - 11:15 AM JST(2:12 AM - 2:15 AM UTC)

Conclusion

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