The 47th Annual Meeting of the Molecular Biology Society of Japan
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Mini-Symposium : [2MS-13] Developing and Applying Innovative Next-Generation Gene Editing Techniques for Mouse Model Generation

[2MS-13]【J】Developing and Applying Innovative Next-Generation Gene Editing Techniques for Mouse Model Generation

Thu. Nov 28, 2024 3:10 PM - 4:30 PM JST
Thu. Nov 28, 2024 6:10 AM - 7:30 AM UTC
Room 13(Fukuoka International Congress Center, 2F 204)
Organizer: Hiroshi Asahara (Institute of Science Tokyo), Satoru Takahashi (University of Tsukuba)
In the context of elucidating the molecular mechanisms underlying human development, regeneration, and repair, as well as understanding the pathophysiology of diseases for drug discovery and therapeutic development, genetic modification in mouse models plays a crucial role. This symposium will present and discuss cutting-edge technologies, such as the combination of CRISPR/Cas9, transposon systems and artificial chromosomes for spatiotemporal editing of multiple genes in mice and the development of reporter mouse systems. These advancements are expected to unveil novel molecular and biological insights for the first time, contributing to the ongoing discourse in the field.
3:10 PM - 3:24 PM JST(6:10 AM - 6:24 AM UTC)

[2MS-13-01]Generation of genome- and epigenome-edited animals

○Izuho Hatada1,2, Takuro Horii1, Sumiyo Morita1, Ryosuke Kobayashi,3, Takehito Kaneko4 (1. Gunma Univ. Mol., 2. Gunma Univ. GIAR, 3. Rakuno Univ., 4. Osaka Metro Univ.)
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3:24 PM - 3:37 PM JST(6:24 AM - 6:37 AM UTC)

[2MS-13-02]Generation of humanized transchromosomic animals via chromosome engineering technology and the application

○Yasuhiro Kazuki1 (1. Tottori University)
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3:37 PM - 3:50 PM JST(6:37 AM - 6:50 AM UTC)

[2MS-13-03]One-step generation of spatiotemporal gene-editing mice by transposon-dependent gRNA delivery.

○Tomoki Chiba1, Hiroshi Asahara1 (1. Institute of Science Tokyo)
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3:50 PM - 4:03 PM JST(6:50 AM - 7:03 AM UTC)

[2MS-13-04]Rapid in vivo genetic screening using Single-step cKO mouse production with PiggyBac (ScKiP) system

○Natsuki Mikami1, Kazuya Murata2, Hayate Suzuki3, Akihiro Kuno3, Satoru Takahashi3, Seiya Mizuno3 (1. Ph.D Program in Human Biology, University of Tsukuba, 2. Center for One Medicine Innovative Translational Research, Gifu University, 3. Institute of Medicine, University of Tsukuba)
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4:03 PM - 4:16 PM JST(7:03 AM - 7:16 AM UTC)

[2MS-13-05]Development of a novel method of gene transduction into fertilized eggs using lipid nanoparticle

○Chihiro Emori1, Hiroki Tanaka2, Hidetaka Akita2, Masahito Ikawa1,3 (1. Osaka University, 2. Tohoku University, 3. The University of Tokyo)
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4:16 PM - 4:30 PM JST(7:16 AM - 7:30 AM UTC)

[2MS-13-06]Visualization technology for ATP dynamics in live mice

○Masamichi Yamamoto1, Takahito Ayano1, Atsushi Nakano1, Aki Oomachi1, Hizuki Hamada1 (1. National Cerebral and Cardiovascular Center)
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