[2MS-07] 【J】Rethinking FTLD-TDP from novel action of causal proteins | The 47th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Mini-Symposium : [2MS-07] Rethinking FTLD-TDP from novel action of causal proteins

[2MS-07]【J】Rethinking FTLD-TDP from novel action of causal proteins

Thu. Nov 28, 2024 3:10 PM - 4:30 PM JST
Thu. Nov 28, 2024 6:10 AM - 7:30 AM UTC

Room 7(Fukuoka International Congress Center, 4F 413)

Organizer: Yoshinori Tanaka (Okayama University of Science), Kei Hashimoto (Ochanomizu University)

Frontotemporal lobar degeneration (FTLD) is a type of dementia characteristic of atrophy in the frontal and temporal lobe. FTLD-TDP, featured by a nuclear protein TDP-43 accumulation in the cytoplasm, dominates about a half of FTLD patients. However, it has not been developed to cure FTLD-TDP because of the unknown mechanism. Here we introduce TDP-43 pathology recently reported and novel action of causal proteins of FTLD-TDP, and discuss the mechanism of FTLD-TDP.

3:10 PM - 3:30 PM JST(6:10 AM - 6:30 AM UTC)

[2MS-07-01]Transition from normal to abnormal TDP-43 is caused by failure of autolysosome formation

○Yoshinori Tanaka¹ (1. Biochem., Vet. Med., Okayama Univ. of Sci.)

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3:30 PM - 3:50 PM JST(6:30 AM - 6:50 AM UTC)

[2MS-07-02]Towards pathological understanding of neurodegenerative diseases by dipeptide repeats derived from aberrant expansion of C9orf72 with a focus on FG motifs

○Yoichi Shinkai¹ (1. AIST)

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3:50 PM - 4:10 PM JST(6:50 AM - 7:10 AM UTC)

[2MS-07-03]Endogenous retroviral regulation by stress-dependent progranulin expression

○Taku Nedachi¹ (1. Toyo Univ.)

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4:10 PM - 4:30 PM JST(7:10 AM - 7:30 AM UTC)

[2MS-07-04]Blockade of endo-lysosomal pathway promotes progranulin-deficient microglial toxicity via proinflammatory lipids

○Kei Hashimoto¹ (1. Ochanomizu Univ.)

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