Session Details
[3PS-04]【E】Understanding the regeneration, immunology, and disorders of the complex organ kidney from a molecular biological perspective
Fri. Nov 29, 2024 4:45 PM - 7:00 PM JST
Fri. Nov 29, 2024 7:45 AM - 10:00 AM UTC
Fri. Nov 29, 2024 7:45 AM - 10:00 AM UTC
Room 4(Fukuoka International Congress Center, 4F 404+405+406)
Organizer: Hiroshi Nishi (The University of Tokyo), Takafumi Toyohara (Tohoku University)
Co-hosted by: Japanese Society of Nephrology
The kidney not only functions as an excretory organ, but also plays a central role in maintaining homeostasis as a metabolic and endocrine organ. However, tissue damages that progress beyond a point of no-return due to chronic inflammation and fibrosis are irreversible. Additionally, because of the structural and physiological complexity, basic researchers have difficulty in joining the research community, and indeed the kidney is one of the most difficult organs to regenerate. Nevertheless, a multiomics approach at a single cell level or temporal and spatial regulation of molecules of interest within an experimental animal, are greatly deepening our understanding of kidney molecular biology.
Introduction
[3PS-04-01]Exploring the biological aging dynamics in a renal development organoid model
○Tomoko Kasahara1, Bohan Zhang2, Yoshiyasu Tongu1, Alexander Tyshkovskiy2, Chiharu Kawabe1, Vadim N. Gladyshev2, Takaaki Abe1 (1. Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine, 2. Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA)
[3PS-04-02(3P-552)]Generation of the organotypic kidney structure solely from pluripotent stem cells
○Shunsuke Tanigawa1, Etsuko Tanaka2, Ryuichi Nishinakamura1 (1. Kumamoto University, 2. University of Miyazaki)
[3PS-04-03]Human Kidney Organoids for Injury and Regeneration
○Ryuji Morizane1,2,3 (1. Massachusetts General Hospital, 2. Harvard Medical School, 3. Harvard Stem Cell Institute)
[3PS-04-04(3P-885)]Downregulation of calcineurin–pyruvate dehydrogenase signaling disrupts energy metabolism in proximal tubule cells and causes kidney fibrosis
○Yasuhiro Oda1, Hiroshi Nishi1, Fumie Hamano2, Teruhiko Yoshida3, Yoshihiro Kita2, Jeffrey B Kopp3, Masaomi Nangaku1 (1. Division of Nephrology and Endocrinology, The University of Tokyo Hospital, 2. Life Sciences Core Facility, The University of Tokyo Graduate School of Medicine, 3. National Institutes of Health)
[3PS-04-05]SOX9 Switch links Regeneration to Fibrosis at the Single-cell level in Mammalian Kidneys
○Sanjeev Kumar1, Shikhar Aggarwal1, Zhanxiang Wang1, David Rincon Fernandez Pacheo1, Anna Rinaldi2, Alex Rajewski1, Jasper Callemeyn3, Elisabet Van Loon3, Baptiste Lamarthee3, Ambart Ester Covarrubias1, Jean Hou1, Michifumi Yamashita1, Haruhiko Akiyama4, S Ananth Karumanchi1, Clive N Svendsen1, Paul W Noble1, Stanley C Jordan1, Joshua Breunig1, Maarten Naesens3, Pietro E Cippa2 (1. Cedars-Sinai Medical Center, Los Angeles, USA, 2. Ente Ospedaliero Cantonale, Lugano, Switzerland, 3. KU Leuven, Leuven, Belgium, 4. Gifu Univ. Gifu, Japan)
[3PS-04-06]Tertiary lymphoid structures: a regional hub for tissue immunity
○Yuki Sato1,2 (1. Mayo Clinic College of Medicine and Science, 2. Graduate School of Medicine Kyoto University)
[3PS-04-07]Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression
○Yi Zhou1, Zhou Liang1, Ziwen Tang1, Changjian Zhu1, Feng Li1, Xu Han1, Ruilin Zheng1, Xinrong Hu1, Ruoni Lin1, Qiaoqiao Pei1 (1. The First Affiliated Hospital, Sun Yat-sen University)