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Wed. Dec 3, 2025

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Blood flow-dependent force parameters instruct endocardial cell identity for the heart morphogenesis

Gene regulation has been explained with signal transduction and transcription factors. However, emerging evidence suggests that gene regulation by “forces" such as cleavage and structural changes of the genome, and pressure to cells is essential for organ formation and function, and that its disruption causes aging and diseases such as cancer. In this symposium, we will invite experts on “forces" at the genome, cell, and organ levels and discuss mechanisms of development, diseases, and medical developments by understanding type, degree, and frequency of forces as gene regulatory information.

【J】Understanding gene expression regulation, development, and disease by the physical microenvironment

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[1MS-10-03]Blood flow-dependent force parameters instruct endocardial cell identity for the heart morphogenesis

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