Session Details
[1MS-10]【J】Understanding gene expression regulation, development, and disease by the physical microenvironment
Wed. Dec 3, 2025 11:15 AM - 12:35 PM JST
Wed. Dec 3, 2025 2:15 AM - 3:35 AM UTC
Wed. Dec 3, 2025 2:15 AM - 3:35 AM UTC
Room 10(Pacifico Yokohama Conference Center 4F, 413)
Organizer: Tomoko Kawai (Okayama University), Norika Liu (Kumamoto University)
Gene regulation has been explained with signal transduction and transcription factors. However, emerging evidence suggests that gene regulation by “forces" such as cleavage and structural changes of the genome, and pressure to cells is essential for organ formation and function, and that its disruption causes aging and diseases such as cancer. In this symposium, we will invite experts on “forces" at the genome, cell, and organ levels and discuss mechanisms of development, diseases, and medical developments by understanding type, degree, and frequency of forces as gene regulatory information.
Introduction
[1MS-10-01]Analysis of mechanical regulation of the genome toward an understanding of organ-specific gene regulation
○Shintaro Yamada1 (1. TMiMS)
[1MS-10-02]Blood flow-induced changes in gene expression and vascular remodeling in endothelial cells
○Kimiko Yamamoto1 (1. The University of Tokyo)
[1MS-10-03]Blood flow-dependent force parameters instruct endocardial cell identity for the heart morphogenesis
○Hajime Fukui1 (1. IAMS, Tokushima University)
[1MS-10-04]Relationship between physical environment and germ cell function and the onset of diseases due to their disruption
○Tomoko Kawai1, Keiji Naruse1 (1. Okayama University)