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Wed. Dec 3, 2025

Thu. Dec 4, 2025

Fri. Dec 5, 2025

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Therapeutic Targeting of Polymerase I–Driven Ribosome Biogenesis in Cancer and Hematologic Disease

Post-transcriptional regulation, including mRNA translation and degradation, has long been considered essential for maintaining cellular homeostasis. However, recent technological advances have challenged conventional views, uncovering novel RNA regulatory mechanisms that play crucial roles in biological processes and disease pathogenesis. The selective translation and degradation of specific mRNAs, as well as the functional roles of non-coding RNAs, have been identified as key factors in cancer, neurological disorders, and other diseases. This symposium will present recent findings on the molecular mechanisms and physiological functions of post-transcriptional regulation, discussing how its dysregulation contributes to disease onset and progression. Additionally, we will explore the potential of targeting RNA regulatory mechanisms for novel therapeutic strategies, aiming to deepen our understanding of RNA dysregulation in disease and its future applications in medicine.

【E】RNA Dysregulation and Disease Mechanisms

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[2AS-07-10]Therapeutic Targeting of Polymerase I–Driven Ribosome Biogenesis in Cancer and Hematologic Disease

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