The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2AS-07]【E】RNA Dysregulation and Disease Mechanisms

Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC
Room 7(Pacifico Yokohama Conference Center 3F, 313+314)
Organizer: Masahiro Morita (University of Texas Health Science Center), Lynne Postovit (Queen's University)
Post-transcriptional regulation, including mRNA translation and degradation, has long been considered essential for maintaining cellular homeostasis. However, recent technological advances have challenged conventional views, uncovering novel RNA regulatory mechanisms that play crucial roles in biological processes and disease pathogenesis. The selective translation and degradation of specific mRNAs, as well as the functional roles of non-coding RNAs, have been identified as key factors in cancer, neurological disorders, and other diseases. This symposium will present recent findings on the molecular mechanisms and physiological functions of post-transcriptional regulation, discussing how its dysregulation contributes to disease onset and progression. Additionally, we will explore the potential of targeting RNA regulatory mechanisms for novel therapeutic strategies, aiming to deepen our understanding of RNA dysregulation in disease and its future applications in medicine.
9:00 AM - 9:01 AM JST(12:00 AM - 12:01 AM UTC)

Introduction

9:01 AM - 9:10 AM JST(12:01 AM - 12:10 AM UTC)

[2AS-07-01]Translational rheostat controls breast cancer metastasis.

○Ivan Topisirovic1 (1. McGill University)
Comment()
9:10 AM - 9:11 AM JST(12:10 AM - 12:11 AM UTC)

Conclusion

9:11 AM - 9:20 AM JST(12:11 AM - 12:20 AM UTC)

[2AS-07-02]TISCA2 reveals hidden translation landscapes in physiology and disease

Kazuya Ichihara1, Taichi Shiraishi1, ○Akinobu Matsumoto1 (1. Nagoya University)
Comment()
9:20 AM - 9:21 AM JST(12:20 AM - 12:21 AM UTC)

Q & A for Each Presentation

9:21 AM - 9:32 AM JST(12:21 AM - 12:32 AM UTC)

[2AS-07-03]The translational repressor, eIF4A2, promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation.

○Professor Martin Bushell1, Madeleine Moore1, Luis Pardo-Fernandez1, Pauline Herviou1, Louise Mitchell1, Ruhi Deshmukh1, Tobias Schmidt1, Stephanie May1, Miryam Muller1, Rachel Smith1, Douglas Strathdee1, Sheila Bryson1, Kelly Hodge1, Sergio Lilla1, Sara Zanivan1, Lynn McGarry1, Sarah Gillan1, Joseph Waldron1, Ruban Peter-Durairaj1, Georgios Kanellos1, Colin Nixon1, Owen Sansom1, Thomas Bird1, Jim Norman1 (1. Cancer Research UK (CRUK))
Comment()
9:32 AM - 9:33 AM JST(12:32 AM - 12:33 AM UTC)

Q & A for Each Presentation

9:33 AM - 9:42 AM JST(12:33 AM - 12:42 AM UTC)

[2AS-07-04(2P-893)]PMR-116, a second generation ribosome biogenesis inhibitor

○Luc Furic1, Rita Ferreira2, Katherine Hannan2, Eric Kusnadi1, Amee George2, Alisee Huglo1, Mitchell Lawrence1, Denis Drygin3, Mustapha Haddach3, Nadine Hein2, Ross Hannan2 (1. Peter Maccallum Cancer Centre, 2. ANU, 3. Pimera)
Comment()
9:42 AM - 9:43 AM JST(12:42 AM - 12:43 AM UTC)

Q & A for Each Presentation

9:43 AM - 9:52 AM JST(12:43 AM - 12:52 AM UTC)

[2AS-07-05]GUG initiation allows dual mitochondrial/nuclear localisation of NSUN2

○Martina Yordanova1, Kyle Meiklejohn1, Fabio Boiocchi1, Lotte de van der Schueren1, Pavel Baranov1 (1. School of Biochemistry and Cell Biology, University College Cork, Ireland)
Comment()
9:52 AM - 9:53 AM JST(12:52 AM - 12:53 AM UTC)

Q & A for Each Presentation

9:53 AM - 10:02 AM JST(12:53 AM - 1:02 AM UTC)

[2AS-07-06]Di-codon composition underlies the ELP3-dependent cancer cell proteome

Kiana Hosseinpour Moghaddam1, Clelia Timpone2, Laasya Naga Gowda2, Dani Tutuka2, Gail P. Risbridger2,3,4, Qishan Lin5, Ralf B. Schittenhelm5, Ivan Topisirovic6, Eric P. Kusnadi2,3,4, Luc Furic2,3,4, ○Ola Larsson1 (1. Karolinska Institute, 2. Peter MacCallum Cancer Centre, 3. University of Melbourne, 4. Monash University, 5. University at Albany, 6. McGill University)
Comment()
10:02 AM - 10:03 AM JST(1:02 AM - 1:03 AM UTC)

Q & A for Each Presentation

10:03 AM - 10:14 AM JST(1:03 AM - 1:14 AM UTC)

[2AS-07-07]Insulin Receptor Network in Regulation of Tumor Initiation

○Vuk Stambolic1 (1. Princess Margaret Cancer Centre/University of Toronto)
Comment()
10:14 AM - 10:15 AM JST(1:14 AM - 1:15 AM UTC)

Q & A for Each Presentation

10:15 AM - 10:23 AM JST(1:15 AM - 1:23 AM UTC)

[2AS-07-08]Targeting Deadenylase-Mediated mRNA Decay Uncovers a New Approach to Treat Metabolic Disorders

○Sakie Katsumura Katsumura1, Masahiro Morita1 (1. University of Texas Health Science Center at San Antonio)
Comment()
10:23 AM - 10:24 AM JST(1:23 AM - 1:24 AM UTC)

Q & A for Each Presentation

10:24 AM - 10:35 AM JST(1:24 AM - 1:35 AM UTC)

[2AS-07-09]The co-transcriptional niche of Microprocessor-driven oncogenic miRNA biogenesis

○Thomas Duchaine1 (1. McGill University)
Comment()
10:35 AM - 10:36 AM JST(1:35 AM - 1:36 AM UTC)

Q & A for Each Presentation

10:36 AM - 10:47 AM JST(1:36 AM - 1:47 AM UTC)

[2AS-07-10]Therapeutic Targeting of Polymerase I–Driven Ribosome Biogenesis in Cancer and Hematologic Disease

○Ross Hannan1, Konstantin Panov2, Amee J George1, Eric Kusnadi3, Mitchell Lawrence4, Mustapha Haddach5, Denis Drygin5, Luc Furic3, Rita Ferreira1, Nadine Hein1 (1. Australian National University, 2. Queen's University, Belfast, 3. Peter MacCallum Cancer Centre, 4. Monash University, 5. Pimera Therapeutics)
Comment()
10:47 AM - 10:48 AM JST(1:47 AM - 1:48 AM UTC)

Q & A for Each Presentation

10:48 AM - 10:59 AM JST(1:48 AM - 1:59 AM UTC)

[2AS-07-11]Enigmatic Translons and Ribosome Decision Graphs: Resolving complexities of eukaryotic RNA translation.

○Pavel Baranov Baranov1 (1. University College Cork)
Comment()
10:59 AM - 11:00 AM JST(1:59 AM - 2:00 AM UTC)

Q & A for Each Presentation

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