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Wed. Dec 3, 2025

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Dynamic reorganization of the Mediator complex in the transition of totipotency-to-pluripotency in early embryogenesis

Enhancers are non-coding regulatory DNA elements that control the temporal and spatial specificity of gene transcription in development. Recent whole genome studies suggest that enhancer polymorphism is highly associated with phenotypic variations and disease risks among populations. Therefore, addressing the question of how enhancers function in development and disease has become increasingly important. In this symposium, we will discuss emerging models of transcriptional regulation by enhancers.

【E】Enhancer function in development and disease

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[2AS-15-04]Dynamic reorganization of the Mediator complex in the transition of totipotency-to-pluripotency in early embryogenesis

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