[2AS-15] 【E】Enhancer function in development and disease | The 48th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Symposium

[2AS-15]【E】Enhancer function in development and disease

Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC

Room 15(Pacifico Yokohama Conference Center 5F, 501)

Organizer: Noriko Saitoh (The Cancer Institute of JFCR ), Takashi Fukaya (The University of Tokyo)

Enhancers are non-coding regulatory DNA elements that control the temporal and spatial specificity of gene transcription in development. Recent whole genome studies suggest that enhancer polymorphism is highly associated with phenotypic variations and disease risks among populations. Therefore, addressing the question of how enhancers function in development and disease has become increasingly important. In this symposium, we will discuss emerging models of transcriptional regulation by enhancers.

9:00 AM - 9:02 AM JST(12:00 AM - 12:02 AM UTC)

Introduction

9:02 AM - 9:16 AM JST(12:02 AM - 12:16 AM UTC)

[2AS-15-01]Transcription dynamics in the early Drosophila embryo

○Takashi Fukaya¹ (1. The University of Tokyo)

Comment()

9:16 AM - 9:20 AM JST(12:16 AM - 12:20 AM UTC)

Q & A for Each Presentation

9:20 AM - 9:36 AM JST(12:20 AM - 12:36 AM UTC)

[2AS-15-02]Cooperative condensation of reprogramming factors in living cells

○Shunsuke Shimobayashi¹ (1. Kyoto University)

Comment()

9:36 AM - 9:40 AM JST(12:36 AM - 12:40 AM UTC)

Q & A for Each Presentation

9:40 AM - 9:56 AM JST(12:40 AM - 12:56 AM UTC)

[2AS-15-03]The spark of life. Initiating transcription in embryos.

○Nadine L Vastenhouw¹ (1. University of Lausanne)

Comment()

9:56 AM - 10:00 AM JST(12:56 AM - 1:00 AM UTC)

Q & A for Each Presentation

10:00 AM - 10:16 AM JST(1:00 AM - 1:16 AM UTC)

[2AS-15-04]Dynamic reorganization of the Mediator complex in the transition of totipotency-to-pluripotency in early embryogenesis

○Hidehisa Takahashi¹, Tomohiko Akiyama¹ (1. Yokohama City University, Graduate School of Medicine)

Comment()

10:16 AM - 10:20 AM JST(1:16 AM - 1:20 AM UTC)

Q & A for Each Presentation

10:20 AM - 10:36 AM JST(1:20 AM - 1:36 AM UTC)

[2AS-15-05]Mapping enhancer-gene regulatory interactions from single-cell data

○Robin Andersson¹ (1. University of Copenhagen)

Comment()

10:36 AM - 10:40 AM JST(1:36 AM - 1:40 AM UTC)

Q & A for Each Presentation

10:40 AM - 10:54 AM JST(1:40 AM - 1:54 AM UTC)

[2AS-15-06]Regulation of enhancers by ncRNA and lysine deacetylation in breast cancer

○Noriko Saitoh¹, Maierdan Palihati ¹, Hiroaki Tachiwana ² (1. The Cancer Institute of JFCR , 2. Hoshi University)

Comment()

10:54 AM - 10:58 AM JST(1:54 AM - 1:58 AM UTC)

Q & A for Each Presentation

10:58 AM - 11:00 AM JST(1:58 AM - 2:00 AM UTC)

Conclusion

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