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Wed. Dec 3, 2025

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Triple-stranded genome structure, R-loops, control emotional experience-induced behavioral plasticity

Experiences with stress and reinforcing substances trigger neural plasticity, driving maladaptive behavioral changes linked to mood and substance use disorders. Emerging evidence highlights the role of transcriptional and epigenetic regulation in behavioral adaptations. This program will discuss cell type- and circuit-specific transcriptional alternations, chromatin accessibility, epigenetic regulators, and long-non-coding RNA-mediated mechanisms in stress and substance use disorders in preclinical model.

【E】Epigenetic and transcriptional mechanisms of Stress and Substance Use-induced behavioral adaptations

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[2PS-06-04]Triple-stranded genome structure, R-loops, control emotional experience-induced behavioral plasticity

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