The 48th Annual Meeting of the Molecular Biology Society of Japan
Advanced Search

Session Details

Symposium

[2PS-06]【E】Epigenetic and transcriptional mechanisms of Stress and Substance Use-induced behavioral adaptations

Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 6(Pacifico Yokohama Conference Center 3F, 311+312)
Organizer: Makoto Taniguchi (Medical University of South Carolina), Shusaku Uchida (Nagoya City University)
Experiences with stress and reinforcing substances trigger neural plasticity, driving maladaptive behavioral changes linked to mood and substance use disorders. Emerging evidence highlights the role of transcriptional and epigenetic regulation in behavioral adaptations. This program will discuss cell type- and circuit-specific transcriptional alternations, chromatin accessibility, epigenetic regulators, and long-non-coding RNA-mediated mechanisms in stress and substance use disorders in preclinical model.
2:20 PM - 2:35 PM JST(5:20 AM - 5:35 AM UTC)

[2PS-06-01(2P-708)]The analysis of the epigenetic mechanisms underlying stress susceptibility in a mouse model of chronic social defeat stress-induced depression

○Sayaka Yamaguchi1,2, Shusaku Uchida3, Yusuke Kishi1,2 (1. Department of Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Laboratory of Molecular Neurobiology, Institute for Quantitative Biosciences, The University of Tokyo, 3. Department of Integrative Stress Science, Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo)
Comment()
2:35 PM - 2:40 PM JST(5:35 AM - 5:40 AM UTC)

Q & A for Each Presentation

2:40 PM - 2:55 PM JST(5:40 AM - 5:55 AM UTC)

[2PS-06-02]Neuroepigenetic mechanisms underlying psychosocial stress-induced behavioral heterogeneity

○Shusaku Uchida1 (1. Institute of Science Tokyo)
Comment()
2:55 PM - 3:00 PM JST(5:55 AM - 6:00 AM UTC)

Q & A for Each Presentation

3:00 PM - 3:15 PM JST(6:00 AM - 6:15 AM UTC)

[2PS-06-03(2P-699)]Gene Regulation Around E-box Motifs Involved in Alcohol Tolerance and Consumption

○Yoshiatsu Aomine1, Koki Sakurai1, Jun Adachi2, Tom Macpherson1, Takaaki Ozawa1, Yoichi Miyamoto2, Yoshihiro Yoneda3, Masahiro Oka2, Takatoshi Hikida1 (1. The Univ. of Osaka, 2. Nat. Inst. Biomedical Innovation (NIBN), 3. Res. Found. for Microbial Diseases of Osaka Univ.)
Comment()
3:15 PM - 3:20 PM JST(6:15 AM - 6:20 AM UTC)

Q & A for Each Presentation

3:20 PM - 3:35 PM JST(6:20 AM - 6:35 AM UTC)

[2PS-06-04]Triple-stranded genome structure, R-loops, control emotional experience-induced behavioral plasticity

○Makoto Taniguchi1, Rose Marie Akiki1, Rebecca Cornbrooks1, Kosuke Magami1, Alain Greige1, Kristen Snyder1, Daniel J Wood1, Mary Claire Herrington1, Philip Mace1, Caila Worley1, Sierra Simmerson1, Kyle Blidy1, Nobuya Koike2, Stefano Berto1, Christopher Cowan1 (1. Medical University of South Carolina, 2. Kyoto Prefectural University of Medicine)
Comment()
3:35 PM - 3:40 PM JST(6:35 AM - 6:40 AM UTC)

Q & A for Each Presentation

3:40 PM - 3:55 PM JST(6:40 AM - 6:55 AM UTC)

[2PS-06-05]Chromatin-mediated alternative splicing in cocaine behavior.

○Elizabeth A Heller1 (1. University of Pennsylvania)
Comment()
3:55 PM - 4:00 PM JST(6:55 AM - 7:00 AM UTC)

Q & A for Each Presentation

4:00 PM - 4:15 PM JST(7:00 AM - 7:15 AM UTC)

[2PS-06-06]Cell-type Specific Regulatory Networks in the Nucleus Accumbens Underlying Oxycodone Addiction in Outbred Rats

Brad Balderson, Narayan Pokhrel1, Arnav Gupta1, Abraham Palmer1, Olivier George1, Graham McVicker, ○Francesca Telese Telese1 (1. University of California San Diego)
Comment()
4:15 PM - 4:20 PM JST(7:15 AM - 7:20 AM UTC)

Q & A for Each Presentation

Back to Category List