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A Germ Cell-Specific RNA-Binding Protein Mediates Specific RNA Accumulation into Membraneless Organelles : The Molecular Mechanism and Functional Co-option in Cancer

RNA-binding protein (RBP) TLS/FUS involved in phase separation binds thousands of RNAs. TLS forms complex with RBPs also binding thousands of RNAs. Then, the TLS complex consists of divergent RBPs and vast numbers of RNAs. Binding of RBP to RNA has both non-specific and specific ones. The binding is precisely regulated with necessity and coincidence. We plan a session of active people working on principle of the complex system, and expect to have a unique debate.

【J】Analysis of working principle of a super complex system governed by RNA and its binding proteins

The 48th Annual Meeting of the Molecular Biology Society of Japan

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[3PS-16-06(3P-163)]A Germ Cell-Specific RNA-Binding Protein Mediates Specific RNA Accumulation into Membraneless Organelles : The Molecular Mechanism and Functional Co-option in Cancer

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