The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[1PS-10]【J】C. elegans in disease research: A versatile model organism

Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 10(Pacifico Yokohama Conference Center 4F, 413)
Organizer: Tsuyoshi Shuto (Kumamoto University), Hayashi Yu (The University of Tokyo)
This symposium will introduce the latest research utilizing C. elegans as a model organism for disease studies. C. elegans serves as a powerful tool in genetics, pharmacology, and molecular biology, providing crucial insights into lifespan, healthspan, and disease-related phenotypic analysis. Furthermore, integrating C. elegans research with studies in mice and humans accelerates the understanding of disease mechanisms and the development of novel therapeutics. This symposium will explore the advantages of C. elegans research and discuss its future prospects.
2:20 PM - 2:35 PM JST(5:20 AM - 5:35 AM UTC)

[1PS-10-01]Inter-tissue communication that regulates the balance between reproduction and lifespan

○Shuhei Nakamura1 (1. Nara Medical University)
Comment()
2:35 PM - 2:50 PM JST(5:35 AM - 5:50 AM UTC)

[1PS-10-02]Exploring regulatory mechanisms and functions of sleep using Caenorhabditis elegans

○Shinichi Miyazaki1,2, Taizo Kawano2, Yu Hayashi1,2 (1. The University of Tokyo, 2. International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba)
Comment()
2:50 PM - 3:05 PM JST(5:50 AM - 6:05 AM UTC)

[1PS-10-03]Development and application of C. elegans disease models for intractable disorders caused by abnormalities in the Sec1/Munc18 family

○Keiko Gengyo-Ando1, Hideki Ando1, Junichi Nakai1 (1. Tohoku Univ. Grad. Sch. Dent. Oral Phyiol.)
Comment()
3:05 PM - 3:20 PM JST(6:05 AM - 6:20 AM UTC)

[1PS-10-04]Pomegranate leaf and branch-derived amyloid disruptor PGG as a therapeutic target for ATTR amyloidosis using a C. elegans model

○Asuka Kagami1, Nami Hashimoto1, Ryoko Sasaki1, Yutaro Fukushima1, Hari Prasad Devkota2,3, Shoya Tanaka2, Kunitoshi Yamanaka4, Shiori Yamakawa5, Ann Suico Mary1,6, Hirofumi Kai1,6, Mitsuharu Ueda5, Tsuyoshi Shuto1,6 (1. Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 2. Department of Instrumental Analysis, Graduate School of Pharmaceutical Sciences, Kumamoto University, 3. Faculty of Humanities and Social Sciences, Kumamoto University, 4. Department of Molecular Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 5. Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, 6. Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Kumamoto University)
Comment()
3:20 PM - 3:30 PM JST(6:20 AM - 6:30 AM UTC)

[1PS-10-05(1P-971)]Elucidation of adverse effects of industrial chemicals and their underlying mechanisms using C. elegans

○Masahiro Tomioka1 (1. National Institute of Occupational Safety and Health, Japan)
Comment()
3:30 PM - 3:40 PM JST(6:30 AM - 6:40 AM UTC)

[1PS-10-06(1P-644)]Pharmacologic and genetic analyses of a C. elegans model for temperature-sensitive male infertility

○Yoshihiro Shimada1, Ayaka Yoshida1, Suzuka Nomura1, Nana Kanazawa1, Kentaro Kawai2, Yukiko Karuo2, Jun Adachi3, Arata Honda4, Jundal Kim5, Akiyoshi Fukamizu6, Masaaki Omote2, Hitoshi Nishimura1 (1. Dept. Lif. Sci., Fac. Sci. Eng., Setsunan Univ., 2. Fac. Pharm. Sci., Setsunan Univ., 3. NIBN(PDD), 4. Ctr. Dev. Adv. Med. Tech., Jichi Med. Univ., 5. Inst. Natl. Med., Toyama Univ., 6. TARA Ctr., Tsukuba Univ.)
Comment()
3:40 PM - 3:50 PM JST(6:40 AM - 6:50 AM UTC)

[1PS-10-07(1P-708)]Dissecting menopause-related neuroendocrine signals using C. elegans: Focusing on sexual dimorphism and temperature-responsive behavior

○Moonsun Jang1,2, Hironori J. Matsuyama3,2, Kotaro D. Kimura1, Ikue Mori2,4 (1. Nagoya City University, 2. Nagoya University, 3. Toyama Prefectural University, 4. Chinese Institute for Brain Research, Beijing)
Comment()
3:50 PM - 4:00 PM JST(6:50 AM - 7:00 AM UTC)

[1PS-10-08(1P-552)]UNC-43/CaMKII regulates presynaptic assembly in C.elegans

○Kota Mizumoto1, Mizuki Kurashina1 (1. University of British Columbia)
Comment()
4:00 PM - 4:10 PM JST(7:00 AM - 7:10 AM UTC)

[1PS-10-09(1P-721)]Temperature acclimation in C. elegans is regulated by detoxification metabolic pathways in the nervous system

○Moe Tezuka1, Misaki Okahata1, Akane Ohta1, Atsushi Kuhara1,2 (1. Laboratory of Molecular and Cellular Regulation Graduate school of Natural Science Konan University, 2. PRIME, AMED)
Comment()
4:10 PM - 4:20 PM JST(7:10 AM - 7:20 AM UTC)

[1PS-10-10(1P-704)]Critical timing of the forgetting promotion signal identified by temporary inhibition of synaptic release.

○Miu Takamatsu1 (1. Kyushu Univ.)
Comment()
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