The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[1AS-11]【E】New Trends in Cell Fate Research in Development, Differentiation, and Regeneration toward Implementation

Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 11(Pacifico Yokohama Conference Center 4F, 414+415)
Organizer: Masahito Matsumoto (Juntendo University), Ken Iwatsuki (Tokyo University of Agriculture)
This symposium explores "cell fate conversion" and its impact on biological phenomena such as development, differentiation, regenerative medicine, and genome editing. It focuses on neural, gustatory, digestive, and pancreatic endocrine cell differentiation, as well as metabolic cell fate determination. Key topics include organoid-based functional organ generation, in vivo gene therapies using cutting-edge genome editing, and the significance of cell-vascular interactions observed via advanced bioimaging. Discussions will cover innovative approaches in regenerative medicine and disease treatment, emphasizing future applications. Understanding cell fate conversion is crucial for novel therapeutic strategies, and this symposium aims to provide a multifaceted perspective, fostering interdisciplinary research and breakthrough advancements.
9:00 AM - 9:01 AM JST(12:00 AM - 12:01 AM UTC)

Introduction

9:01 AM - 9:21 AM JST(12:01 AM - 12:21 AM UTC)

[1AS-11-01]Clinical Application of Intestinal Epithelial Stem Cell Organoids in Inflammatory Bowel Disease

○Mamoru Watanabe1 (1. Juntendo University)
Comment()
9:21 AM - 9:24 AM JST(12:21 AM - 12:24 AM UTC)

Q & A for Each Presentation

9:24 AM - 9:36 AM JST(12:24 AM - 12:36 AM UTC)

[1AS-11-02(1P-615)]Development and Characterization of Human Pancreatic Tuft Cells and Taste Cells Using Organoid Technology

○Tatsuya Kometani1, Kosuke Sakaguchi1, Hiroo Imai2, Hirofumi Fukushima4, Koji Kawaguchi3, Ken Iwatsuki1 (1. Dept. of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo Univ. of Agriculture, 2. Center for the Evolutionary Origins of Human Behavior, Kyoto Univ., 3. Dept. of Oral & Maxillofacial Surgery, Tsurumi Univ. School of Dental Medicine, 4. Head and Neck Oncology Center, Showa Medical Univ.)
Comment()
9:36 AM - 9:37 AM JST(12:36 AM - 12:37 AM UTC)

Q & A for Each Presentation

9:37 AM - 9:52 AM JST(12:37 AM - 12:52 AM UTC)

[1AS-11-03]Molecular Insights into Innovative Direct Cell Fate Conversion (DIVER) for Cellular and Gene Therapy Targeting Severe Hypoglycemia

○Masahito Matsumoto1 (1. Juntendo University)
Comment()
9:52 AM - 9:54 AM JST(12:52 AM - 12:54 AM UTC)

Q & A for Each Presentation

9:54 AM - 10:11 AM JST(12:54 AM - 1:11 AM UTC)

[1AS-11-04]Therapeutic Programming of Somatic Cells via In Vivo Genome Editing toward Treatment of Multifactorial Diseases

○Keiichiro Suzuki1 (1. The Univ. of Osaka)
Comment()
10:11 AM - 10:14 AM JST(1:11 AM - 1:14 AM UTC)

Q & A for Each Presentation

10:14 AM - 10:34 AM JST(1:14 AM - 1:34 AM UTC)

[1AS-11-05]SCALABLE GENERATION OF 3D PANCREATIC ISLET ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS IN SUSPENSION BIOREACTORS

○Juan Alvarez1 (1. University of Pennsylvania)
Comment()
10:34 AM - 10:37 AM JST(1:34 AM - 1:37 AM UTC)

Q & A for Each Presentation

10:37 AM - 10:57 AM JST(1:37 AM - 1:57 AM UTC)

[1AS-11-06]Imaging of Neurovascular Dysfunction

○Yoh-suke Mukouyama1 (1. NHLBI, NIH)
Comment()
10:57 AM - 10:59 AM JST(1:57 AM - 1:59 AM UTC)

Q & A for Each Presentation

10:59 AM - 11:00 AM JST(1:59 AM - 2:00 AM UTC)

Conclusion

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