Session Details
[1PS-12]【J】Mechanisms of physiological and pathological functions driven by changes in the extracellular environment
Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 12(Pacifico Yokohama Conference Center 4F, 416+417)
Organizer: Hideki Tatsukawa (Nagoya University), Noriyuki Kioka (Kyoto University)
The extracellular environment not only serves as a structural scaffold for cells but also regulates cell function and behavior, playing a crucial role in tissue homeostasis and repair. Changes in the ECM, secreted factors, and physical environment influence tissue remodeling and physiological functions through cell-cell interactions and signal transduction. These alterations are also implicated in the pathogenesis of inflammation, fibrosis, and tumor progression. This symposium aims to examine the cellular and tissue-level effects of extracellular environment changes, providing a platform for sharing and discussing the latest research findings.
Introduction
[1PS-12-01]Mechanosensor-Mediated Regulation of Physiological Functions by the Extracellular Microenvironment
○Noriyuki Kioka1 (1. Kyoto University)
[1PS-12-02(1P-415)]Actin Crosslinking Proteins Mediate Myosin Contractile Force Applied to Cell-Cell Adhesion
○Nobutomo Fujimoto1,2, Doan Manh2, Hiroki Katsuta2, Hiroaki Hirata3, Keiji Naruse2 (1. Okayama University, Medical School, 2. Okayama University, Department of Cardiovascular Physiology, 3. Kanazawa Institute of Technology, Department of Life Science and Biotechnology)
[1PS-12-03]Drug-Induced Paradoxical Activation of c-Src Promotes Invadopodia Formation
○Sawako Yamashiro1,2, Yating Yang2, Ying Liu1, Naoki Watanabe1,2 (1. Kyoto Univ. Grad. Sch. of Biostudies, 2. Kyoto Univ. Grad. Sch. of Medicine)
[1PS-12-04]In vivo sperm collective turbulence driven by non-Newtonian extracellular fluid
○Tsuyoshi Hirashima1 (1. National University of Singapore, Mechanobiology Institute)
[1PS-12-05]Molecular mechanisms underlying plasma membrane damage-induced cellular senescence and its implications in disease pathogenesis
○Kojiro Suda1, Jan Grašič1, Nurhanani Razali1, Yatzu Chiu1, Hunter Barbee1, Yohsuke Moriyama1, Keiko Kono1 (1. Okinawa Institute of Science and Technology)
[1PS-12-06]Development a vascular permeability test device that mimics blood vessels and the surrounding stromal tissue using ECM.
○Kae Sato1 (1. Japan Women's University)
[1PS-12-07]Physiological function and homeostatic roles of the ECM derived peptide.
○Kumiko Takemori1 (1. Department of food and nutrition, Faculty of agriculture, Kindai University)
[1PS-12-08]Elucidation of pathogenic molecular mechanisms of fibrosis by targeting crosslinking enzymes
○Hideki Tatsukawa Tatsukawa1, Kiyotaka Hitomi1 (1. Nagoya University)
[1PS-12-09]Matrix stiffness contributes to pancreatic cancer progression via ATF5 activation
○Seiichiro Ishihara1, Enomoto Atsushi2, Akihiro Sakai2, Tadashi Iida2, Hisashi Haga1 (1. Hokkaido University, 2. Nagoya University Graduate School of Medicine)