Session Details
[1AS-15]【E】The Frontiers and New Advances in Gene Expression Regulation Research
Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 15(Pacifico Yokohama Conference Center 5F, 501)
Organizer: Noriaki Sasai (Nara Institute of Science and Technology), Nayuta Yakushiji-Kaminatsui (RIKEN)
Gene expression regulation in animals is governed by diverse mechanisms, including signaling pathways, transcription factors, chromatin regulation, transposable elements, and three-dimensional genome structures. These regulatory mechanisms are not only involved in biological processes such as embryogenesis, aging, and disease onset but also contribute to species-specific regulatory systems that have played a role in the evolution of life. This symposium brings together researchers employing in vitro and in vivo approaches to elucidate biological phenomena and understand pathologies caused by disruptions in regulatory mechanisms. The goal is to discuss the diversity of gene expression regulatory systems and explore future perspectives in this field.
Introduction
[1AS-15-01]CtBP1/2 modulates enhancer-promoter contact frequency in developing limbs
○Nayuta Yakushiji-Kaminatsui1, Yoko Koseki1, Takaho A Endo1, Manabu Nakayama2, Haruhiko Koseki1 (1. RIKEN Center for Integrative Medical Sciences , 2. Kazusa DNA Research Institute)
Q & A for Each Presentation
[1AS-15-02]Regulation of transposons by SPIN1 via MIWI2-piRNA independent mechanism
○Hiromi Yamada1, Chikara Takeuchi2, Koshi Imami1, Yuka W. Iwasaki1 (1. RIKEN IMS, 2. Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center)
Q & A for Each Presentation
[1AS-15-03(1P-134)]Polymeric mechanism of positive feedback between promoter and enhancer activities
○Tetsuya Yamamoto1, Koji Kawasaki2, Takashi Fukaya2 (1. Hokkaido Univ. , 2. Tokyo Univ.)
Q & A for Each Presentation
[1AS-15-04]scRepli-RamDA-seq: a multi-omics technology enabling the analysis of gene expression dynamics during S-phase
○Rawin Poonperm1,2, Taiki Yoneda1, Taito Imada1, Saori Takahashi2, Takako Ichinose2, Hisashi Miura2, Tetsutaro Hayashi3, Mariko Kuse3, Mika Yoshimura3, Koji Nagao4, Chikashi Obuse4, Itoshi Nikaido3,5, Ichiro Hiratani2, Shin-ichiro Takebayashi1 (1. Laboratory of Molecular and Cellular Biology, Graduate School of Bioresources, Mie University, 2. Laboratory for Developmental Epigenetics, RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, 3. Laboratory for Bioinformatics Research, RIKEN Center for Biosystems Dynamics Research (BDR), Wako, 4. Department of Biological Sciences, Graduate School of Science, Osaka University, 5. Functional Genome Informatics, Division of Medical Genomics, Medical Research Institute, Tokyo Medical and Dental University)
Q & A for Each Presentation
[1AS-15-05(1P-317)]Mapping evolutionary variants that drive human specific gene expression changes
○YIZHI YAN1,2, Nadav Mishol3, Katharina Lange3, Simon Fishilevich3, Zicong Zhang1, Omer Ronen3, Rika Tsujikawa1, Bourque Guillaume1,2,4, David Gokhman3, Fumitaka Inoue1 (1. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan, 2. Department of Human Genetics, McGill University, Montréal, Québec, Canada, 3. Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel, 4. Canadian Center for Computational Genomics, McGill University, Montréal, Québec, Canada)
Q & A for Each Presentation
[1AS-15-06]Polycomb Repressive Complex Establishes H3K27me3 Mega-Domains during Neocortical Maturation
○Natsumi Yamada1, Chika Ichihara1, Hiroki Sugishita1, Yukiko Gotoh1,2 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. The University of Tokyo International Research Center for Neurointelligence (WPI-IRCN))
Q & A for Each Presentation
[1AS-15-07(1P-121)]A common retinal cis-regulatory code underlying genomic sequence diversity
○Yohei Ogawa1,2, Yu Liu2, Joseph C. Corbo2 (1. National Institute of Genetics, 2. Washington University School of Medicine)
Q & A for Each Presentation
[1AS-15-08]Inter-species differences in gene expression regulation that brough about the diversity of hindlimb positions in tetrapods
○Takayuki Suzuki1 (1. Osaka Metropolitan University)
Q & A for Each Presentation
[1AS-15-09]Functional characterization and therapeutic targeting of gene regulatory elements
○Nadav Ahituv1,2 (1. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA., 2. Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA.)