The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Mini-Symposia

[1MS-15]【J】The molecular and cellular mechanisms of aging

Wed. Dec 3, 2025 11:15 AM - 12:35 PM JST
Wed. Dec 3, 2025 2:15 AM - 3:35 AM UTC
Room 15(Pacifico Yokohama Conference Center 5F, 501)
Organizer: Toshiaki Watanabe (National center for child health and development), Tomoichiro Miyoshi (RIKEN)
What are the underlying mechanisms that cause aging? DNA mutations, gene expression changes, mitochondrial metabolism, and cellular degeneration are thought to be at the root of the aging, but the whole picture is unknown. It has also been suggested that epigenetic clocks and SASP factors are involved in the regulation of aging. In this symposium, researchers who are conducting research on mechanisms and technology development to approach the essence of aging will present their latest research results and discuss them.
11:15 AM - 11:18 AM JST(2:15 AM - 2:18 AM UTC)

Introduction

11:18 AM - 11:28 AM JST(2:18 AM - 2:28 AM UTC)

[1MS-15-01]Anti-aging mechanisms in primate spermatogonial stem cells

○Toshiaki Watanabe1 (1. National Center for Child Health and Development)
Comment()
11:28 AM - 11:33 AM JST(2:28 AM - 2:33 AM UTC)

Q & A for Each Presentation

11:33 AM - 11:43 AM JST(2:33 AM - 2:43 AM UTC)

[1MS-15-02]Investigation of the aging mechanisms of oocytes originating from primordial follicles

○Go Nagamatsu1, Riku Yamashita1, Ayuka Tsukamoto1, Yusei Mitsui1, Nao Fumoto1, Tomohiro Kohama1 (1. University of Yamanashi)
Comment()
11:43 AM - 11:48 AM JST(2:43 AM - 2:48 AM UTC)

Q & A for Each Presentation

11:48 AM - 11:50 AM JST(2:48 AM - 2:50 AM UTC)

Introduction

11:50 AM - 12:00 PM JST(2:50 AM - 3:00 AM UTC)

[1MS-15-03]Mechanisms of human retrotransposon inhibition during cellular senescence

○Tomoichiro Miyoshi1, Yukiko Fumoto1, Ahmad Luqman-Fatah1 (1. RIKEN IMS)
Comment()
12:00 PM - 12:05 PM JST(3:00 AM - 3:05 AM UTC)

Q & A for Each Presentation

12:05 PM - 12:15 PM JST(3:05 AM - 3:15 AM UTC)

[1MS-15-04]Cryo-EM analysis of nucleotide excision repair in cells

○Syota Matsumoto1, Yoshimasa Takizawa1, Kana Hashimoto1, Mitsuo Ogasawara1, Hitoshi Kurumizaka1 (1. IQB, The University of Tokyo)
Comment()
12:15 PM - 12:20 PM JST(3:15 AM - 3:20 AM UTC)

Q & A for Each Presentation

12:20 PM - 12:30 PM JST(3:20 AM - 3:30 AM UTC)

[1MS-15-05]Elucidation of the aging process caused by mitochondrial DNA mutation

○Naoto Yoshinaga1,2 (1. CSRS, RIKEN, 2. IAB, Keio Univ.)
Comment()
12:30 PM - 12:35 PM JST(3:30 AM - 3:35 AM UTC)

Q & A for Each Presentation

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