The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[1PS-16]【E】The Mechanobiology Theater: Behind the Scenes of Mechanical Signals

Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 16(Pacifico Yokohama Conference Center 5F, 502)
Organizer: Fumio Motegi (Hokkaido University), Erina Kuranaga (Kyoto University)
This symposium delves into the forefront of mechanobiology, examining how cells and tissues sense and respond to mechanical forces. The speakers will present diverse perspectives on topics such as cellular mechanosensing, tissue morphogenesis, and cell movement. Emphasis will be placed on the integration of mechanical signals into cellular processes, including cell fate decisions, polarity, and tissue development. Insights from plants, animals, and cutting-edge live imaging will be discussed, shedding light on the role of mechanical forces across different biological systems.
2:20 PM - 2:23 PM JST(5:20 AM - 5:23 AM UTC)

Introduction

2:23 PM - 2:46 PM JST(5:23 AM - 5:46 AM UTC)

[1PS-16-01]Mechano-chemical crosstalk induced by microtubules in directed cell migration

Yukako Nishimura1, Tatsuki Kondo1, Ryota Orii2, Taketoshi Kambara4, Kaori Kuribayashi-Shigetomi3, Yasushi Okada5,6, Hirokazu Tanimoto2, ○Fumio Motegi1 (1. IGM, Hokkaido Univ, 2. Yokohama City Univ, 3. IAGE, Hokkaido Univ, 4. RIKEN BDR, 5. Grad Sch Sci, Univ of Tokyo, 6. Grad Sch Med, Univ of Tokyo)
Comment()
2:46 PM - 3:09 PM JST(5:46 AM - 6:09 AM UTC)

[1PS-16-02]Mechanical compression impacts on macrophage phagocytic potential in dead adipocyte clearance

○Yusuke J Toyama1,2 (1. Mechanobiology Institute, National Univ. of Singapore., 2. Dep. Bio. Sci., National Univ. of Singapore.)
Comment()
3:09 PM - 3:32 PM JST(6:09 AM - 6:32 AM UTC)

[1PS-16-03]Actomyosin drives both apical polarization and membrane transport for lumen formation during tubulogenesis

○Yuji Mizotani1, Edwin Munro1 (1. Univ. of Chicago)
Comment()
3:32 PM - 3:55 PM JST(6:32 AM - 6:55 AM UTC)

[1PS-16-04]The mechanosensitive ion channel DmMSL10 acts as a mechanosensor in the Venus flytrap

○Masatsugu Toyota1,2,3 (1. Saitama Univ., 2. Suntory Fdn. Life Sci., 3. Huazhong Agric. Univ.)
Comment()
3:55 PM - 4:18 PM JST(6:55 AM - 7:18 AM UTC)

[1PS-16-05]Mechanostress during confined neuronal migration causes transient DNA damage in the developing brain

○Kengaku Mineko1, Zhejing Zhang2, Canela Andres3, Yusuke Kishi4, Hiroyuki Sasanuma5 (1. iCeMS, Kyoto Univ., 2. Dept Biostudies, Kyoto Univ., 3. RBC, Kyoto Univ., 4. Inst. Quant. Biosci., Univ. Tokyo, 5. Tokyo Metro. Inst. Med. Sci.)
Comment()
4:18 PM - 4:20 PM JST(7:18 AM - 7:20 AM UTC)

Conclusion

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