Session Details
[1AS-17]【J】Single-cell Regulome Linking Health and Disease
Wed. Dec 3, 2025 9:00 AM - 11:00 AM JST
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Wed. Dec 3, 2025 12:00 AM - 2:00 AM UTC
Room 17(Pacifico Yokohama Conference Center 5F, 503)
Organizer: Seitaro Nomura (The University of Tokyo), Hiroyuki Aburatani (The University of Tokyo)
Where is the boundary between health and disease? In an organism composed of countless cells, how do individual cells regenerate within organs, and how do they coordinate with other cells to sustain function? What exactly is disease? What defines it?Advancements in cutting-edge technologies—such as single-cell analysis, spatial omics, digital AI, imaging, genome editing, and modeling—have dramatically transformed life science research in recent years. By integrating these state-of-the-art approaches, we are now beginning to uncover the boundary between health and disease, offering new possibilities for controlling and treating diseases. At this symposium, leading researchers at the forefront of these technologies will come together to explore how we can manipulate the balance between health and disease. Join us as we discuss the future direction of life science research.
[1AS-17-01]Single-cell Regulome Linking Health and Disease
○Seitaro Nomura1 (1. The University of Tokyo)
[1AS-17-02]Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivo
○Makoto Nakanishi1 (1. The University of Tokyo)
[1AS-17-03]Multicellular society of bone: homeostatic maintenance and disease pathogenesis
○Kazuo Okamoto1 (1. Cancer Research Institute, Kanazawa University)
[1AS-17-04(1P-770)]Single Cell and Spatial Transcriptome Profiling of Temporal Artery Biopsies Reveals Molecular Pathology of Giant Cell Arteritis
○Nobumasa Watanabe1, Makoto Sugihara1,2, Yuichiro Hara1,3, Kazunari Sekiyama4, Eisuke Takamasu5, Naofumi Chinen6, Kota Shimada5, Hideya Kawaji1 (1. Tokyo Metropolitan Institute of Medical Science, Research Center for Genome & Medical Sciences, 2. Tokyo Metropolitan Tama-Hokubu Medical Center, 3. Kitasato University School of Frontier Engineering, 4. Tokyo Metropolitan Institute of Medical Science, Center for Medical Research Cooperation, 5. Tokyo Metropolitan Tama Medical Center, 6. Tokyo Metropolitan Tama-Nambu Chiiki Hospital)
[1AS-17-05]Uncovering Kidney Cell Diversity and Interactions by Single-Cell Analysis
○Motoko Yanagita1 (1. Kyoto University)
[1AS-17-06]Single cell analysis and drug discovery for hematological malignancies and infectious diseases
○Makoto Yamagishi1 (1. Univ. Tokyo)
[1AS-17-07(1P-888)]Development of a classification model to distinguish cancer from normal epithelium using spatial transcriptomics of colorectal cancer tissue
○Shunsuke A Sakai1,2, Ryosuke Nomura1,3, Masaki Ohira1,2, Kyoko Kurihara1,2, SungGi Chi1, Yuki Matsubara1, Yukiko Morinaga4, Ken Kato4, Kojima Motohiro4, Ayako Suzuki3, Yutaka Suzuki3, Katsuya Tsuchihara1,2, Shun-Ichiro Kageyama1, Riu Yamashita1,3 (1. Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 2. Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, 3. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 4. Department of Surgical Pathology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine)
[1AS-17-08]Exploring the mechanism of bidirectional differentiation of AFP-producing gastric cancer using single cell analysis
○Aya Nonaka1, Genta Nagae1, Ichita Osawa1, Toshiro Sato2, Hiroyuki Aburatani1 (1. Gen. Sci. & Med. Div., RCAST, The Univ. of Tokyo, 2. Dept. Organoid Med., Keio Univ Sch. Med.)
[1AS-17-09]Spatial heterogeneity of AFP-producing gastric carcinoma
○Hiroyuki Aburatani1, Kazuhiro Osawa1, Genta Nagae1 (1. The University of Tokyo)