Session Details
[1PS-09]【E】Mechanistic insight into the three-dimensional organization of chromosomes
Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 9(Pacifico Yokohama Conference Center 4F, 411+412)
Organizer: Kristian Jeppsson (The University of Tokyo), Toyonori Sakata (The University of Tokyo)
Chromosomes are dynamically organized in three-dimensional space to allow the proper expression, repair and duplication of the genetic material. By introducing new insights from cutting-edge techniques such as genome-wide sequencing and single-molecule analyses, this symposium aims to shed light on the mechanisms controlling chromosome structure and their relationship with diseases.
Introduction
[1PS-09-01]Investigating how Nse5/6 regulates the chromosomal association of Smc5/6
○Kristian Jeppsson1,2, Jumpei Fukute1,2, Toyonori Sakata1,2, Katsuhiko Shirahige1,2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Cell and Molecular Biology, Karolinska Institutet)
Q & A for Each Presentation
[1PS-09-02]Why does a chromosome look like a chromosome?
○Frank Uhlmann1 (1. The Francis Crick Institute)
Q & A for Each Presentation
[1PS-09-03(1P-108)]A multilayered regulatory system that tunes condensin II for mitotic chromosome assembly
○Makoto Michael Yoshida1, Kazuhisa Kinoshita2, Yuuki Aizawa2, Tatsuya Hirano2, Tomoko Nishiyama1 (1. Kyoto University, 2. RIKEN)
Q & A for Each Presentation
[1PS-09-04]3D chromatin organisation by sister chromatid cohesion
Aya Tsukada1, Sina Kühnel1, Marie Albert1, Kaima Tsukada3, Luis Sanchez-Pulido2, Adrian Henggeler1, Duygu Yilmaz3, Jenny Gruhn3, Ignasi Roig4, Eva Hoffmann3, Thomas Miller3, Andrew Blackford3, ○Fena Ochs1 (1. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 2. Institute of Genetics and Cancer, the University of Edinburgh MRC Human genetics Unit, Edinburgh, Scotland, UK, 3. Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 4. Institut de Biotecnologia i Biomedicina, Universitate Autonoma de Barcelona, Cerdanyola de Valles, Barcelona, Spain)
Q & A for Each Presentation
[1PS-09-05(1P-138)]Cohesin promotes initiation and restrains pause release in RNA Pol II transcription
○Shoin Tei1, Masashige Bando1, Katsuhiko Shirahige1 (1. The Univeristy of Tokyo)
Q & A for Each Presentation
[1PS-09-06]MukBEF and Topoisomerase IV solve DNA entanglements produced by transcription and replication in Escherichia coli.
○Andres Center Canela1, Nadim Majdalani2, Naohiro Osada1, Shar-yin N Huang3 (1. Kyoto University, 2. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 3. Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH)
Q & A for Each Presentation
[1PS-09-07]A common molecular mechanism underlying Cornelia de Lange and CHOPS syndromes
○Toyonori Sakata1,2, Shoin Tei1, Masashige Bando1, Katsuhiko Shirahige1,2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Karolinska Inst., CMB)