Session Details
[1PS-09]【E】Mechanistic insight into the three-dimensional organization of chromosomes
Wed. Dec 3, 2025 2:20 PM - 4:20 PM JST
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Wed. Dec 3, 2025 5:20 AM - 7:20 AM UTC
Room 9(Pacifico Yokohama Conference Center 4F, 411+412)
Organizer: Kristian Jeppsson (The University of Tokyo), Toyonori Sakata (The University of Tokyo)
Chromosomes are dynamically organized in three-dimensional space to allow the proper expression, repair and duplication of the genetic material. By introducing new insights from cutting-edge techniques such as genome-wide sequencing and single-molecule analyses, this symposium aims to shed light on the mechanisms controlling chromosome structure and their relationship with diseases.
Introduction
[1PS-09-01]Investigating how Nse5/6 regulates the chromosomal association of Smc5/6
○Kristian Jeppsson1,2, Jumpei Fukute1,2, Toyonori Sakata1,2, Katsuhiko Shirahige1,2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Department of Cell and Molecular Biology, Karolinska Institutet)
Q & A for Each Presentation
[1PS-09-02]Why does a chromosome look like a chromosome?
○Frank Uhlmann1 (1. Chromosome Segregation Laboratory, The Francis Crick Institute, London NW1 1AT, UK)
Q & A for Each Presentation
[1PS-09-03(1P-108)]A multilayered regulatory system that tunes condensin II for mitotic chromosome assembly
○Makoto Michael Yoshida1, Kazuhisa Kinoshita2, Yuuki Aizawa2, Tatsuya Hirano2, Tomoko Nishiyama1 (1. Kyoto University, 2. RIKEN)
Q & A for Each Presentation
[1PS-09-04(2P-113)]Investigating the interplay between DNA Topology and 3D genome folding
○Evanthia Iliopoulou1, Vladislav Kuzin1, Toyonori Sakata1,2, Marie-Josèphe Giraud-Panis3, Katsuhiko Shirahige1,2, Camilla Björkegren1, Laura Baranello1 (1. Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden, 2. Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan, 3. Institute for Research on Cancer and Aging, Nice (IRCAN), Faculty of Medicine, University Côte d’Azur, 06107 Nice, France)
Q & A for Each Presentation
[1PS-09-05(1P-138)]Cohesin promotes initiation and restrains pause release in RNA Pol II transcription
○Shoin Tei1, Masashige Bando1, Katsuhiko Shirahige1 (1. The Univeristy of Tokyo)
Q & A for Each Presentation
[1PS-09-06]MukBEF and Topoisomerase IV solve DNA entanglements produced by transcription and replication in Escherichia coli.
○Andres Canela1, Nadim Majdalani2, Naohiro Osada1, Shar-yin N Huang3 (1. Kyoto University, 2. Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 3. Laboratory of Molecular Pharmacology, Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH)
Q & A for Each Presentation
[1PS-09-07]A common molecular mechanism underlying Cornelia de Lange and CHOPS syndromes
○Toyonori Sakata1,2, Shoin Tei1, Masashige Bando1, Katsuhiko Shirahige1,2 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Karolinska Inst., CMB)