[2MS-01] 【J】Genome Medicine and Genome Metabolism, Response, and Repair | The 48th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Mini-Symposia

[2MS-01]【J】Genome Medicine and Genome Metabolism, Response, and Repair

Thu. Dec 4, 2025 11:15 AM - 12:35 PM JST
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC

Room 1(Pacifico Yokohama Conference Center 1F, Main Hall)

Organizer: Shinichiro' Nakada (Kyoto Prefectural University of Medicine), Yuka Nakazawa (Nagoya University)

Many genetic disorders have extremely poor prognoses, with only a limited window of opportunity between diagnosis and the initiation of treatment. In recent years, advances in genomic diagnostic technologies, along with emerging therapeutic approaches such as gene therapy and nucleic acid-based medicine, have been anticipated as groundbreaking treatment strategies for rare and intractable diseases. Furthermore, new discoveries in basic medicine and biology are accelerating these developments. This symposium will present the latest research findings contributing to the diagnosis and treatment of refractory genetic diseases from multiple perspectives.

11:15 AM - 11:18 AM JST(2:15 AM - 2:18 AM UTC)

Introduction

11:18 AM - 11:33 AM JST(2:18 AM - 2:33 AM UTC)

[2MS-01-01]FEN1 counteracts 53BP1-dependent replication stress induced by a thymidine analog, alovudine (ALV)

○Ryotaro Kawasumi¹, Md Bayejid Hosen¹, Kouji Hirota¹ (1. Tokyo Metropolitan University)

Comment()

11:33 AM - 11:48 AM JST(2:33 AM - 2:48 AM UTC)

[2MS-01-02]Induction of Long Deletions by Trans- and Cis-Nick Pairs and Application to Disease Cells

Yuya Namaki^1,2, Akiko Tomita¹, Yusuke Kojima³, Akitsu Hotta³, ○Shinichiro Nakada¹ (1. Kyoto Pref. Univ. Med., 2. Osaka Univ., 3. Kyoto Univ.)

Comment()

11:48 AM - 12:03 PM JST(2:48 AM - 3:03 AM UTC)

[2MS-01-03]Xeroderma pigmentosum -diagnosis and current topics-

○Mariko Tsujimoto¹ (1. Division of Dermatology, Department of Internal Related, Graduate School of Medicine, Kobe University)

Comment()

12:03 PM - 12:18 PM JST(3:03 AM - 3:18 AM UTC)

[2MS-01-04]A ninth complementation group in xeroderma pigmentosum, XP-J

○Lin Ye^1,2, Yuka Nakazawa^1,2, Yasuyoshi Oka², Hironobu Morinaga², Kana Kato², Mayuko Shimada², Kotaro Tsukada², Koyo Tsujikawa², Yosuke Nishio², Hiva Fassihi^3,4, Shehla Mohammed^3,4, Alan Lehmann^3,4,5, Tomoo Ogi^2,6,7,8 (1. Department of Molecular Genetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2. Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan, 3. National Xeroderma Pigmentosum Service, Department of Photodermatology, St John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London, United Kingdom, 4. Rare Diseases Centre, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 5. Genome Damage and Stability Centre, University of Sussex, Brighton, United Kingdom, 6. Department of Human Genetics, Graduate School of Medicine, Nagoya University, Nagoya, Japan, 7. Center for One Medicine Innovative Translational Research (COMIT), Gifu University Institute for Advanced Study, Gifu, Japan, 8. Division of Molecular Physiology and Dynamics, Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System, Nagoya, Japan)

Comment()

12:18 PM - 12:33 PM JST(3:18 AM - 3:33 AM UTC)

[2MS-01-05]Development of antisense therapeutics for neurodegenerative diseases

○Kentaro Sahashi¹ (1. Nagoya University)

Comment()

12:33 PM - 12:35 PM JST(3:33 AM - 3:35 AM UTC)

Conclusion

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