The 48th Annual Meeting of the Molecular Biology Society of Japan
Advanced Search

Session Details

Mini-Symposia

[2MS-11]【E】Dynamic Interactions and Functional Analysis of Protein Complexes

Thu. Dec 4, 2025 11:15 AM - 12:35 PM JST
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Room 11(Pacifico Yokohama Conference Center 4F, 414+415)
Organizer: Masateru Takahashi (King Abdullah University of Science and Technology)
This symposium will present cutting-edge research on how dynamic interactions within protein complexes contribute to their functions. We will highlight studies employing advanced techniques such as single-molecule fluorescence imaging, mass spectrometry, NMR, and cryo-electron microscopy (cryo-EM) to elucidate the roles and regulatory mechanisms of protein complexes in various biological processes, including DNA replication, transcription, signal transduction, and DNA repair. Additionally, we will discuss approaches that integrate computational methods, such as deep learning-based data analysis and molecular dynamics simulations, to provide a comprehensive understanding of these complex systems.
11:15 AM - 11:17 AM JST(2:15 AM - 2:17 AM UTC)

Introduction

11:17 AM - 11:35 AM JST(2:17 AM - 2:35 AM UTC)

[2MS-11-01]Coupling of Leading- and Lagging-Strand Synthesis in Human and SV40 Replisomes

○Masateru Takahashi Takahashi1, Amani Al-Amodi1, Muhammad Tehseen1, Yujing Ouyang1, Ammar Usman Danazumi1, Alfredo De Biasio1, Samir M Hamdan1 (1. King Abdullah University of Science and Technology)
Comment()
11:35 AM - 11:38 AM JST(2:35 AM - 2:38 AM UTC)

Q & A for Each Presentation

11:38 AM - 11:56 AM JST(2:38 AM - 2:56 AM UTC)

[2MS-11-02]Real-time imaging of rotation during synthesis by the replisome

○Karl Duderstadt1,2, Thomas M Retzer1,2, Lional T Rajappa1,2, Maserteru Takahashi3, Samir M Hamdan3 (1. Structure and Dynamics of Molecular Machines, Max Planck Institute of Biochemistry; Martinsried, Germany, 2. Department of Bioscience, Technical University of Munich; Garching, Germany, 3. Bioscience Program, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology; Thuwal, Kingdom of Saudi Arabia)
Comment()
11:56 AM - 11:59 AM JST(2:56 AM - 2:59 AM UTC)

Q & A for Each Presentation

11:59 AM - 12:09 PM JST(2:59 AM - 3:09 AM UTC)

[2MS-11-03(2P-247)]A Platform for the Development of E3 Ligase-Targeting Modulatory Peptides for Cancer Therapy

○Andrej Paluda1,2,3, Shun Nakamura2, Yoshinori Fujiyoshi2, Donald Cameron1, Catherine Day3 (1. University of Tokyo, Institute for Quantitative Biosciences, 2. Institute of Science Tokyo, Advanced Research Initiative, Institute of Integrated Research, 3. University of Otago, School of Biomedical Sciences, Department of Biochemistry)
Comment()
12:09 PM - 12:12 PM JST(3:09 AM - 3:12 AM UTC)

Q & A for Each Presentation

12:12 PM - 12:30 PM JST(3:12 AM - 3:30 AM UTC)

[2MS-11-04]Mechanistic Insights into Dynamic Protein Interactions in DNA Mismatch Repair

○Jong-Bong Lee1 (1. POSTECH)
Comment()
12:30 PM - 12:33 PM JST(3:30 AM - 3:33 AM UTC)

Q & A for Each Presentation

12:33 PM - 12:35 PM JST(3:33 AM - 3:35 AM UTC)

Conclusion

Back to Category List