[2AS-12] 【E】Transgenerational Biology: DOHaD theory revisited | The 48th Annual Meeting of the Molecular Biology Society of Japan

Session Details

Symposium

[2AS-12]【E】Transgenerational Biology: DOHaD theory revisited

Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC

Room 12(Pacifico Yokohama Conference Center 4F, 416+417)

Organizer: Takahiro Nemoto (Nippon Medical School), Shiro Tochitani (Suzuka University of Medical Science)

The DOHaD theory has become widely recognized, highlighting how early-life environments shape health and disease susceptibility. While the impact of unfavorable conditions is evident on offspring, the detailed mechanisms of transgenerational trait transmission remain unclear. Here, we discuss the molecular pathways linking environmental exposures and acquired trait inheritance across generations.

9:00 AM - 9:30 AM JST(12:00 AM - 12:30 AM UTC)

[2AS-12-01]Transgenerational inheritance of thrifty phenotype and the effect of re-write by nutritional intervention

○Takahiro Nemoto¹ (1. Nippon Medical School)

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9:30 AM - 10:00 AM JST(12:30 AM - 1:00 AM UTC)

[2AS-12-02]The SMARCA5–DMRT1 Pioneer Complex Establishes Epigenetic Priming to Direct Male Germline Differentiation

○Yuka Kitamura¹, Yasuhisa Munakata¹, Hironori Abe¹, Mengwen Hu¹, Satoyo Oya¹, Shanmathi Murugesan¹, Mahnoor Rizwan¹, Shawna P Katz¹, David J Picketts², Richard M Schultz¹, Satoshi H Namekawa¹ (1. University of California, Davis, 2. University of Ottawa)

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10:00 AM - 10:30 AM JST(1:00 AM - 1:30 AM UTC)

[2AS-12-03]Intergenerational inheritance through the gut microbiome-germline axis

○Ayele Argaw Denboba^1,2, Thomas S. B. Schmidt Schmidt³, Monica Di Giacomo², Bobby Ranjan², Saravanan Devendran³, Eleonora Mastrorilli³, Catrin T. Lloyd², Danilo Pugliese², Violetta Paribeni², Juliette Dabin², Alessandra Pisaniello², Sergio Espinola², Alvaro Crevenna², Subhanita Ghosh⁴, Neil Humphreys², Olga Boruc², Peter Sarkies^4,5, Michael Zimmermann³, Peer Bork^3,6,7, Jamie A. Hackett² (1. Max Planck Institute of Immunobiology and Epigenetics, 2. European Molecular Biology Laboratory (EMBL), Epigenetics & Neurobiology Unit, Rome, Italy., 3. European Molecular Biology Laboratory (EMBL), Structural & Computational Biology Unit,Heidelberg, Germany., 4. MRC London Institute for Medical Science (LMS), London, UK, 5. Department of Biochemistry, University of Oxford, Oxford, UK, 6. Department of Bioinformatics, Biozentrum, University of Würzburg, Würzburg, Germany, 7. Yonsei Frontier Lab (YFL), Yonsei University, Seoul, South Korea)

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10:30 AM - 11:00 AM JST(1:30 AM - 2:00 AM UTC)

[2AS-12-04]Maternal gut microbiota as a transgenerational regulator of offspring development

○Shiro Tochitani¹ (1. Suzuka University of Medical Science)

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