The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2PS-16]【J】Quantitative Biology of Heterogeneity Regulation 2025

Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 16(Pacifico Yokohama Conference Center 5F, 502)
Organizer: Jun Nakayama (Osaka International Cancer Institute), Kenichi Miyata (Cancer Institute, Japanese Foundation for Cancer Research)
Recent breakthroughs in omics and single-cell analysis reveals cellular heterogeneity and gene-expressional heterogeneity in various situation, including development, aging, and cancer. In this symposium, we will take a “quantitative" viewpoint of heterogeneity and approach the essence of the mechanism in heterogeneity. The regulation and dynamics of heterogeneity will be discussed from broad-based field including quantitative analysis of heterogeneity, single-cell analysis, and in vivo live imaging.
2:20 PM - 2:23 PM JST(5:20 AM - 5:23 AM UTC)

Introduction

2:23 PM - 2:35 PM JST(5:23 AM - 5:35 AM UTC)

[2PS-16-01]Chronological Profiling of Irreversible Epigenetic Heterogeneity

○Takuya Kajitani1, Hiroaki Kato2, Hiroshi Kimura3, Yasuyuki Ohkawa4, Chikashi Obuse5, Damien Hermand6, John Lis7, Masashi Kajita9, Yota Murakami8 (1. Nara Medical University, 2. Shimane Univ., 3. Tokyo Tech, 4. Kyushu Univ., 5. Osaka Univ., 6. Univ of Namur, 7. Cornell Univ., 8. Hokkaido Univ., 9. Univ. of Fukui)
Comment()
2:35 PM - 2:38 PM JST(5:35 AM - 5:38 AM UTC)

Q & A for Each Presentation

2:38 PM - 2:45 PM JST(5:38 AM - 5:45 AM UTC)

[2PS-16-02(2P-823)]Light Scattering Spectrum as a New Tool for Single-Cell Quantitative Analysis of Tumors

○Fuka Takeuchi1, Yuka Tsuri2, Yuichi Kimura3, Takashi Nagaoka4, Yoichiroh Hosokawa2,5, Akihiko Ito1 (1. Dept. Pathol., Fac. Med., Kindai Univ., 2. Div. of Materials Sci., NAIST, 3. Fac. of Inform., Cyber Inform. Inst., Kindai Univ., 4. Dept. of Computational Sys. Biology, Fac. of Biology-Oriented Sci., & Tech., Kindai Univ., 5. Medilux Research Center, NAIST)
Comment()
2:45 PM - 2:47 PM JST(5:45 AM - 5:47 AM UTC)

Q & A for Each Presentation

2:47 PM - 2:59 PM JST(5:47 AM - 5:59 AM UTC)

[2PS-16-03]New Insights into the Mechanisms Underlying Cancer Cell Heterogeneity Driven by Epigenomic Dysregulation

○Kenichi Miyata1,2, Yuxiao Yang1, Chikako Shibata1, Takaaki Furukawa1, Yuhang Liu1, Yuta Uneme1, Kohei Kumekawa2, Reo Maruyama1,2 (1. Division of Cancer Epigenomics, Cancer Institute, JFCR, 2. NEXT-Ganken, JFCR)
Comment()
2:59 PM - 3:02 PM JST(5:59 AM - 6:02 AM UTC)

Q & A for Each Presentation

3:02 PM - 3:17 PM JST(6:02 AM - 6:17 AM UTC)

[2PS-16-04]Dissecting Cellular Heterogeneity Using Advanced Transcriptomic Profiling Methods

○Akiko Oguchi1,2, Raku Son1,2, Yasuhiro Murakawa1,2 (1. RIKEN Center for Integrative Medical Sciences, 2. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University)
Comment()
3:17 PM - 3:20 PM JST(6:17 AM - 6:20 AM UTC)

Q & A for Each Presentation

3:20 PM - 3:32 PM JST(6:20 AM - 6:32 AM UTC)

[2PS-16-05]Unique Metabolic Alteration of Intracellular Branched-Chain Amino Acid Heterogeneity Defines Breast Cancer Malignancy

○Kenkyo Matsuura1, Ririko Shinonaga1, Mizuki Yamamoto2, Yukako Watanabe3, Mamoru Takada4, Jun-ichiro Inoue5, Satoshi Arai6, Ayuna Hattori1, Hiromi Imamura7, Takahiro Ito1 (1. Inst. Life Med. Sci., Kyoto Univ., 2. Inst. Med. Sci., Univ. Tokyo, 3. Dept. Breast Surg., Sch. Med., Intl. Univ. Health and Welfare, 4. Dept. Gen. Surg., Grad. Sch. Med., Chiva Univ., 5. UTOPIA, Univ. Tokyo, 6. NanoLSI, Kanazawa Univ., 7. Org. Res. Init., Yamaguchi Univ.)
Comment()
3:32 PM - 3:35 PM JST(6:32 AM - 6:35 AM UTC)

Q & A for Each Presentation

3:35 PM - 3:50 PM JST(6:35 AM - 6:50 AM UTC)

[2PS-16-06]Decoding Complex Traits’ Heterogeneity from Genetic Evidence

○Masaru Koido1,2 (1. Graduate School of Frontier Sciences, The University of Tokyo, 2. RIKEN Center for Integrative Medical Sciences)
Comment()
3:50 PM - 3:53 PM JST(6:50 AM - 6:53 AM UTC)

Q & A for Each Presentation

3:53 PM - 4:00 PM JST(6:53 AM - 7:00 AM UTC)

[2PS-16-07(2P-899)]Quantitative Analysis of Pancreatic Cancer Heterogeneity through Persister Cells

○YUXIAO YANG1,2, YUHANG LIU1, Yuta Uneme1, Chikako Shibata1, Takaaki Furukawa1, Reo Maruyama1,3, Kenichi Miyata1,3 (1. Division of Cancer Epigenomics, Cancer Institute, JFCR, 2. Graduate School of Medical and Dental Sciences, 3. NEXT-Ganken, JFCR)
Comment()
4:00 PM - 4:02 PM JST(7:00 AM - 7:02 AM UTC)

Q & A for Each Presentation

4:02 PM - 4:09 PM JST(7:02 AM - 7:09 AM UTC)

[2PS-16-08(2P-692)]Analysis of the temperature sensing mechanism by multiple thermo-receptors in a single thermosensory neuron and the significance of the presence of multiple thermo-receptors.

○Nanako Kanamura1,2, Akane Ohta1,2, Yuki Sato1,2, Akira Kawanabe3, Yuichiro Fujiwara4,3, Atsushi Kuhara1,2,5 (1. Graduate School of Natural Science, Konan University, Kobe, Japan, 2. Institute for Integrative Neurobiology, Konan University, Kobe, Japan, 3. Faculty of Medicine, Kagawa University, Kagawa, 4. Graduate School of Biomedical and Health Sciences (Medical), Hiroshima University, Hiroshima, Japan, 5. PRIME, AMED)
Comment()
4:09 PM - 4:11 PM JST(7:09 AM - 7:11 AM UTC)

Q & A for Each Presentation

4:11 PM - 4:18 PM JST(7:11 AM - 7:18 AM UTC)

[2PS-16-09(2P-853)]Analysis of HER2 Heterogeneity and Associated Phenotypes in Breast Cancer

○Shota Katayama1, Kentaro Semba1,2, Yusuke Yamamoto3, Jun Nakayama4 (1. Dept. of Life Sci. & Med. Biosci., Grad. Sch. of Sci. & Eng., Waseda Univ., 2. TR Ctr., Fukushima Med. Univ., 3. Lab. Integr. Oncol., Natl. Cancer Ctr. Res. Inst., 4. Dept. of Oncogenesis Growth Regulation, Res Inst., Osaka Intl. Cancer Inst.)
Comment()
4:18 PM - 4:20 PM JST(7:18 AM - 7:20 AM UTC)

Q & A for Each Presentation

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