Session Details
[2MS-17]【E】The Biology of Brain Size Determination and the Pathology of Microcephaly
Thu. Dec 4, 2025 11:15 AM - 12:35 PM JST
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Room 17(Pacifico Yokohama Conference Center 5F, 503)
Organizer: Noriko Osumi (Tohoku University), Mikio Hoshino (National Center of Neurology and Psychiatry)
Brain size varies widely among species, with its regulation critical in developmental and evolutionary biology. This symposium highlights the molecular mechanisms that regulate brain size, using mammals with different brain sizes, such as mice, ferrets, marmosets, and humans. The pathology of microcephaly caused by dysregulated brain-size machinery will also be discussed.
[2MS-17-01]Synthetic approach toward understanding of autosomal recessive primary microcephaly MCPH
○Fumio Matsuzaki1,2, Ikumi Fujita2, Hiroshi Kiyonari2, Taeko Suetsugu1,2, Akira Fujimori3 (1. Kyoto University, 2. RIKEN , 3. NIRS-QST)
[2MS-17-02]Microcephaly-associated gene, AUTS2, promotes upper-layer neuron production
○Kazumi Shimaoka1, Mikio Hoshino1 (1. NCNP)
[2MS-17-03]Microcephaly Associated with Chromosome 1q21.1 Deletion
○Toru Takumi1 (1. Kobe University)
[2MS-17-04]Kinesin-like motor protein KIF23 maintains neural stem and progenitor cells: Insights into the pathogenesis of microcephaly
○Takako Kikkawa1, Sharmin Naher1, Noriko Osumi1 (1. Dept Dev Neurosci, Tohoku Univ Grad Sch Med)
[2MS-17-05]MECP2-mutant marmosets exhibit primate-specific phenotypes of Rett syndrome
○Noriyuki Kishi1,2 (1. RIKEN Center for Brain Science, 2. Keio Regenerative Medicine Research Center)