The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2PS-18]【E】Diabetes: Novel insights into mechanisms of impaired insulin secretion and insulin resistance

Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 18(Pacifico Yokohama Conference Center 5F, 511+512)
Organizer: Yuta Hiraike (The University of Tokyo), Yasutaka Miyachi (Kyushu University)
Diabetes develops as a result of both impaired insulin secretion from β cells and insulin resistance in muscle, liver, and adipose. Here, emerging scientists will join to share latest findings from molecular biology-based mechanistic analysis as well as large-scale data science. We aim to gain new insights into novel mechanisms, drug targets, and future precision medicine approaches of diabetes.
2:20 PM - 2:25 PM JST(5:20 AM - 5:25 AM UTC)

Introduction

2:25 PM - 2:45 PM JST(5:25 AM - 5:45 AM UTC)

[2PS-18-01]In vivo regulatory mechanisms of function and mass in human pancreatic β-cells

○Jun Shirakawa1 (1. Institute for Molecular and Cellular Regulation (IMCR), Gunma University)
Comment()
2:45 PM - 3:05 PM JST(5:45 AM - 6:05 AM UTC)

[2PS-18-02]Physiological regulation of UCP1 activity in brown adipose tissue during hibernation in Syrian hamsters: its potential implications for metabolic diseases

○Yuko Okamatsu-Ogura1 (1. Hokkaido University)
Comment()
3:05 PM - 3:25 PM JST(6:05 AM - 6:25 AM UTC)

[2PS-18-03]Impact of Glucose-lowering Medications on Skeletal Muscle Metabolic Adaptation and Exercise Capacity

○Yasutaka Miyachi1,2, Shintaro Nakamura2, Yoshihiro Ogawa2 (1. Kyushu University Hospital, 2. Kyushu University)
Comment()
3:25 PM - 3:45 PM JST(6:25 AM - 6:45 AM UTC)

[2PS-18-04]Machine learning-based prediction model of insulin resistance: toward risk stratification, novel biology, and beyond

○Yuta Hiraike1 (1. The University of Tokyo)
Comment()
3:45 PM - 4:00 PM JST(6:45 AM - 7:00 AM UTC)

[2PS-18-05]Functional genomic analyses of a T2D GWAS locus reveal a novel lncRNA that regulates C2cd4a gene expression

○Taiyi Diana Kuo1 (1. University of California Davis)
Comment()
4:00 PM - 4:10 PM JST(7:00 AM - 7:10 AM UTC)

[2PS-18-06(2P-307)]Mechanism of muscle atrophy in a normal-weight rat model of type 2 diabetes

○Akieda Sayaka1, Yukako Nishizaki1, Fumitake Yamaguchi1, Yukari Date1 (1. University of Miyazaki)
Comment()
4:10 PM - 4:20 PM JST(7:10 AM - 7:20 AM UTC)

[2PS-18-07(2P-457)]Does reduction of upstream molecules in the insulin signaling pathway explain obesity-induced insulin resistance?

○So Morishita1, Shinsuke Uda2, Hiroyuki Kubota1 (1. Kyushu University, 2. Yamaguchi University)
Comment()
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