The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2AS-03]【J】Multidisciplinary research on neurogenerative disorders

Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC
Room 3(Pacifico Yokohama Conference Center 3F, 302)
Organizer: Tomohide Saio (Tokushima University), Masaki Okumura (Tohoku University)
The causes of neurodegenerative diseases are extremely complex. Although abnormalities in nucleic acids and proteins that lead to neurodegenerative diseases are reported, a critical treatment remain unexplored. This symposium aims to stimulate new ideas by introducing cutting-edge research, from basic research on abnormalities in nucleic acids and proteins involved in neurodegenerative diseases to applied research to overcome these diseases.
9:00 AM - 9:03 AM JST(12:00 AM - 12:03 AM UTC)

Introduction

9:03 AM - 9:23 AM JST(12:03 AM - 12:23 AM UTC)

[2AS-03-01]Advances in Neurodegenerative Disease Research Utilizing iPS Cell Technology

○Haruhisa Inoue1,2,3 (1. Center for iPS Cell Research and Application, Kyoto University, 2. RIKEN BioResource Research Center, 3. RIKEN Center for Advanced Intelligence Project)
Comment()
9:23 AM - 9:30 AM JST(12:23 AM - 12:30 AM UTC)

[2AS-03-02(2P-704)]Molecular mechanism of UNC13A dysregulation as a convergent outcome of functional loss of ALS-associated RNA-binding proteins

○Yasuaki Watanabe1,2, Naoki Suzuki1,3, Tadashi Nakagawa2,4, Masaki Hosogane2, Tetsuya Akiyama1, Satoru Morimoto6,7, Hideyuki Okano6,7, Masashi Aoki1, Keiko Nakayama2,5 (1. Department of Neurology, Graduate School of Medicine, Tohoku University,, 2. Division of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, 3. Department of Rehabilitation Medicine, Graduate School of Medicine, Tohoku University, 4. Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 5. Research Infrastructure Management Center, Institute of Science Tokyo, 6. Keio University Regenerative Medicine Research Center (KRM), 7. Division of Neurodegenerative Disease Research, Tokyo Metropolitan Institute for Geriatrics and Gerontology)
Comment()
9:30 AM - 9:50 AM JST(12:30 AM - 12:50 AM UTC)

[2AS-03-03]Neurodegenerative Disease Characterized by the Fibril Polymorphisms

○Kensuke Ikenaka Ikenaka1, Keita Kakuda1, Aguirre Cesar1, Chi-Jin Choong1 (1. Graduate School of Medicine, The University of Osaka)
Comment()
9:50 AM - 10:10 AM JST(12:50 AM - 1:10 AM UTC)

[2AS-03-04]Hsp70/Hsp40 Chaperone-Mediated Disaggregation Revealed by Real-Time Fluorescence Imaging

○Yoshiko Nakagawa1, Shingo Tamai1,2, Takashi Nomura1, Scott Thomas1,2, Motomasa Tanaka1 (1. RIKEN, 2. Institute of Science Tokyo)
Comment()
10:10 AM - 10:17 AM JST(1:10 AM - 1:17 AM UTC)

[2AS-03-05(2P-159)]Investigation of the structure and interaction of an RNA aptamer targeting α-synuclein using NMR

○XIANG LI1,2, Yudai Yamaoki1,2, Takashi Nagata1,2, Kazuma Murakami3, Masato Katahira1,2 (1. Institute of Advanced Energy, Kyoto University, 2. Graduate School of Energy Science, Kyoto University, 3. Graduate School of Agriculture, Kyoto University)
Comment()
10:17 AM - 10:37 AM JST(1:17 AM - 1:37 AM UTC)

[2AS-03-06]The mechanism of neurodegeneration by G-quadruplexes

○Norifumi Shioda1 (1. Kumamoto Univ.)
Comment()
10:37 AM - 10:57 AM JST(1:37 AM - 1:57 AM UTC)

[2AS-03-07]Development of methods for controlling nucleic acid structures involved in neurodegenerative diseases using pseudocellular systems

○Hisae Tateishi-Karimata1,2 (1. FIRST, Konan University, 2. FIBER, Konan University)
Comment()
10:57 AM - 11:00 AM JST(1:57 AM - 2:00 AM UTC)

Conclusion

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