The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2PS-03]【J】Exploring Chromosomal Diversity: Impact and Significance

Thu. Dec 4, 2025 2:20 PM - 4:20 PM JST
Thu. Dec 4, 2025 5:20 AM - 7:20 AM UTC
Room 3(Pacifico Yokohama Conference Center 3F, 302)
Organizer: Minji Jo (Cancer Institute, Japanese Foundation For Cancer Research), Tomonori Matsumoto (The University of Osaka)
Perturbed regulation of cell division leads to structural or numerical changes in chromosomes. This resulting chromosomal diversity not only alters gene expression and disrupts the cell cycle but also drives the acquisition of novel cellular properties. This diversity contributes to cellular heterogeneity, aging, and cancer development cancer. In this symposium, we aim to comprehensively explore the impact of chromosomal diversity across cellular, tissue, and organismal levels, integrating the latest multifaceted research findings to discuss its biological significance.
2:20 PM - 2:21 PM JST(5:20 AM - 5:21 AM UTC)

Introduction

2:21 PM - 2:36 PM JST(5:21 AM - 5:36 AM UTC)

[2PS-03-01]Loss of Y Chromosome

○Soichi Sano1 (1. National Cerebral and Cardiovascular Center)
Comment()
2:36 PM - 2:51 PM JST(5:36 AM - 5:51 AM UTC)

[2PS-03-02(2P-095)]Structural Robustness of Inactive X Chromosome Heterochromatin in Human Somatic Cells

○Asahi Yamaki1, Ren Matsui1, Takamasa Ito1, Shinya Isobe1, Chikashi Obuse1 (1. Osaka Univ.)
Comment()
2:51 PM - 3:06 PM JST(5:51 AM - 6:06 AM UTC)

[2PS-03-03]Understanding mechanisms underlying formation and maintenance of ecDNA

○Mariko Sasaki1 (1. National Institute of Genetics)
Comment()
3:06 PM - 3:21 PM JST(6:06 AM - 6:21 AM UTC)

[2PS-03-04]Therapeutic target discovery in extrachromosomal DNA–positive cancers

○Seiko Yoshino1, Yohei Sugimoto1, Hiroshi I Suzuki1 (1. Div. Molecular Oncology, Nagoya Univ. Grad. Sch. Med.)
Comment()
3:21 PM - 3:36 PM JST(6:21 AM - 6:36 AM UTC)

[2PS-03-05(2P-623)]Mechanisms and impact of diploidization in mouse haploid embryos during preimplantation development

○Koya Shimabukuro1, PAN Tao1, Natsumi Taira2, Miho Ohsugi1,2 (1. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 2. Department of Biological Sciences, Graduate School of Science, The University of Tokyo)
Comment()
3:36 PM - 3:51 PM JST(6:36 AM - 6:51 AM UTC)

[2PS-03-06]The impact of whole-genome duplication on mitotic control in animal cells

○Ryota Uehara1, QiJiao Wang1 (1. Hokkaido University)
Comment()
3:51 PM - 4:05 PM JST(6:51 AM - 7:05 AM UTC)

[2PS-03-07]Adaptive Strategies of Cancer Stem Cells Driven by Chromosomal Diversity

○Minji Jo1, Oletea Sampetrean2, Tetsuya Negoto3, Hidenobu Yoshitake3, Utako Kato1, Hideyuki Saya4, Toru Hirota1 (1. Cancer Institute, Japanese Foundation for Cancer Research, 2. Human Biology-Microbiome-Quantum Research Center, Keio Univ., 3. Department of Neurosurgery, School of medicine, Kurume Univ., 4. Oncology Innovation Center, Fujita Health Univ.)
Comment()
4:05 PM - 4:19 PM JST(7:05 AM - 7:19 AM UTC)

[2PS-03-08]The Impact of Ploidy Changes on Human Cancer Pathogenesis

○Tomonori Matsumoto1 (1. The University of Osaka)
Comment()
4:19 PM - 4:20 PM JST(7:19 AM - 7:20 AM UTC)

Conclusion

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