The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[2AS-04]【J】Genome regulation by transposable elements

Thu. Dec 4, 2025 9:00 AM - 11:00 AM JST
Thu. Dec 4, 2025 12:00 AM - 2:00 AM UTC
Room 4(Pacifico Yokohama Conference Center 3F, 303)
Organizer: Kishita Yoshihito (Kindai University), Taisuke Nakahama (The University of Osaka)
Mammalian transosable elements include LINE, SINE, LTR retrotransposons and DNA transposons. While transposable elements create genetic diversity and promote evolutionary change, they can also cause disease. As transposable elements move in the host genome, they can reorganize the genome and also influence the regulation of gene expression and epigenetic changes. In this symposium, we would like to discuss the latest findings of phenomena involving genome regulation mediated by transposable elements.
9:00 AM - 9:05 AM JST(12:00 AM - 12:05 AM UTC)

Introduction

9:05 AM - 9:16 AM JST(12:05 AM - 12:16 AM UTC)

[2AS-04-01]Identification of genetic variations involving retrotransposons in patients with intractable diseases

○Yoshihito Kishita1,2, kohta Nakamura2, Yukiko Yatsuka2, Ayumu Sugiura2, Atsuko Okazaki2, Akira Ohtake3, Kei Murayama2, Yasushi Okazaki2 (1. Kindai University, 2. Juntendo University, 3. Saitama Medical University)
Comment()
9:16 AM - 9:32 AM JST(12:16 AM - 12:32 AM UTC)

[2AS-04-02]Analysis of novel LINE-1 insertion sites in the postmortem brains of patients with psychiatric disorder

○Miki Bundo1 (1. Kumamoto Univ.)
Comment()
9:32 AM - 9:48 AM JST(12:32 AM - 12:48 AM UTC)

[2AS-04-03]Long-read transcriptome analysis reveals retrotransposon-mediated diversification of transcript structures and translational regulation

○Mahoko Takahashi Ueda1, Jun Inamo2, Yuta Kochi1 (1. Science Tokyo, 2. Univ. of Colorado)
Comment()
9:48 AM - 10:04 AM JST(12:48 AM - 1:04 AM UTC)

[2AS-04-04]Expansion of cis-regulatory networks during neural differentiation mediated by transposable elements

○Hidenori Nishihara1, Atsushi Komiya1 (1. Faculty of Agriculture, Kindai University)
Comment()
10:04 AM - 10:16 AM JST(1:04 AM - 1:16 AM UTC)

[2AS-04-05(2P-110)]A pangenome approach to human LINE-1 epigenetics in polymorphic region.

○Nhi Hoang Nhi1, Guillaume Bourque1 (1. Kyoto University)
Comment()
10:16 AM - 10:28 AM JST(1:16 AM - 1:28 AM UTC)

[2AS-04-06(2P-505)]RUNX1 transcriptionally suppresses LINE1 in hematopoietic stem cells.

○Motomi Osato1,5, Bibek Dutta2, Arusyak Ivanyan1, Michelle Meng Huang Mok2, Haruhito Totani2, Yong Tham Chen 2, Akiko Niibori-Nambu2, Chu Guo 3, Yutaka Nakachi3, Miki Bundo3, Toshio Suda2, Wee-Joo Chng 2, Kimi Araki4, Kazuya Iwamoto3, Goro Sashida1 (1. Kumamoto Univ. IRCMS, 2. Natl. Univ. Singapore, CSI, 3. Grad. Sch.Med. Sci., Kumamoto Univ., 4. Kumamoto Univ. IRDA, 5. Kumamoto Kenhoku Hosp.)
Comment()
10:28 AM - 10:44 AM JST(1:28 AM - 1:44 AM UTC)

[2AS-04-07]The role of STING/MAVS signaling in antitumor immunity

○Shunsuke Kitajima1 (1. Japanese Foundation for Cancer Research)
Comment()
10:44 AM - 11:00 AM JST(1:44 AM - 2:00 AM UTC)

[2AS-04-08]RNA Splicing Aberrations and Genomic Structural Variants Induced by Mobile Elements

○Yuichi Shiraishi1 (1. National Cancer Center Research Institute)
Comment()
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