Session Details
[2MS-05]【J】Advances in Vasohibin and Detyrosination Research
Thu. Dec 4, 2025 11:15 AM - 12:35 PM JST
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Room 5(Pacifico Yokohama Conference Center 3F, 304)
Organizer: Miho Kobayashi (Institute of Science Tokyo), Yutaka Furutani (The Jikei University School of Medicine)
Vasohibin (VASH) family are tubulin carboxypeptidases (TCPs) that induce one of the post-translational modifications of α-tubulin known as "detyrosination". VASHs (and other TCP: MATCAPs) have been the subject of extensive research worldwide. While these TCPs differ in expression profiles and functions, some TCP studies have not sufficiently considered their physiological roles. This session brings together researchers aiming to elucidate the fundamental roles of VASH, presenting and discussing the latest findings from VASH research, which originated in Japan.
Introduction
[2MS-05-01(2P-284)]Functional characterization of tubulin carboxypeptidases in endothelial and non-endothelial cells
○Yuji Tsuyama1,2, Miho Kobayashi1, Tetsuro Watabe1 (1. Dept.of Biochemi., SCIENCE TOKYO, 2. Dept. of Oral and Maxillofacial Surgical Oncology., SCIENCE TOKYO)
Q & A for Each Presentation
[2MS-05-02]Structural Analysis and Functional Characterization of Vasohibin
○Hana Yamashita1, Syo Ito1, Tatsuya Nishino1 (1. Tokyo University of Science)
Q & A for Each Presentation
[2MS-05-03]Screening of compounds that inhibit the interaction between Vasohibin-2 and SVBP
○YUTAKA FURUTANI1, Kaori Yanaka1, Yasuhiro Suzuki2, Yasufumi Sato3 (1. Jikei Uni. Sch. of Med., 2. Tohoku Uni., 3. Kibounomori Clinic)
Q & A for Each Presentation
[2MS-05-04]Vasohibin family enhances chemosensitivity in ovarian cancer cells through the regulation of microtubule dynamics
○Takahiro Koyanagi1, Yasushi Saga1, Yoshifumi Takahashi1, Yuji Takei1, Hiroyuki Fujiwara1 (1. Jichi Medical University)
Q & A for Each Presentation
[2MS-05-05]Detyrosinated α-tubulin expression as a potential target for chronic kidney disease
○Ryoya Aoki1, Katsuyuki Tanabe1 (1. Okayama University)
Q & A for Each Presentation
[2MS-05-06]The anti-aging mystery of VASH1-deficient mice: Insights into healthy longevity from vascular endothelial cells
○Miho Kobayashi1,2, Honoka Hirose1, Miki Yokozawa1,3, Masanori Nakayama4,2, Tetsuro Watabe1 (1. Dept. of Biochem., Science Tokyo, 2. Lab. for Cell Polar. and Organ., MPI for Heart and Lung Res, 3. Dept. Mol. and Cell. Med., Inst. of Med. Sci., Tokyo Medical Univ., 4. Org. for Res. Strat. and Dev., Okayama Univ., Japan)