The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Mini-Symposia

[2MS-07]【J】Shaping the Future with Gene Editing Technologies: New Horizons in Developmental Engineering

Thu. Dec 4, 2025 11:15 AM - 12:35 PM JST
Thu. Dec 4, 2025 2:15 AM - 3:35 AM UTC
Room 7(Pacifico Yokohama Conference Center 3F, 313+314)
Organizer: Masamichi Yamamoto (National Cerebral and Cardiovascular Center ), Izuho Hatada (Gunma University)
Model mice are indispensable tools for elucidating biological phenomena and studying disease mechanisms. In recent years, innovative technologies such as genome editing, human artificial chromosomes, and other cutting-edge advancements have propelled the field to new heights. This symposium will showcase groundbreaking insights achieved through spatiotemporal gene manipulation, humanization at the chromosomal level, and single-cell real-time imaging using advanced reporters. Join us to delve into the forefront of research and engage in in-depth discussions about these transformative discoveries.
11:15 AM - 11:16 AM JST(2:15 AM - 2:16 AM UTC)

Introduction

11:16 AM - 11:29 AM JST(2:16 AM - 2:29 AM UTC)

[2MS-07-01]In vivo screening of essential genes using Cas9-based germline-specific conditional knockout mice

○Chi Lieu Kim Nguyen1, Madoka Aoki1, Fumihiro Sugiyama2, Seiya Mizuno2 (1. PhD. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, 2. Laboratory Animal Resource Center and Trans-Border Medical Research Center, University of Tsukuba)
Comment()
11:29 AM - 11:42 AM JST(2:29 AM - 2:42 AM UTC)

[2MS-07-02]Generation of conditional genome-edited mice using a transposon system

○Maiko Inotsume1, Tomoki Chiba1, Takahide Matsushima1, Masayasu Sega1, Kasumi Yumoto1, Mikako Kawaguchi1, Hiroshi Asahara1,2 (1. Institute of SCIENCE TOKYO, 2. The Scripps Research Institute)
Comment()
11:42 AM - 11:55 AM JST(2:42 AM - 2:55 AM UTC)

[2MS-07-03]Sperm-specific epigenome editing system

○Takuro Horii1, Sumiyo Morita1, Shinjiro Hino2, Yuko Hino2, Hiroto S Fukushima3, Ryosuke Kobayashi1, Mika Kimura1, Mitsuyoshi Nakao2, Yoichi Mizukami4, Azusa Inoue3, Izuho Hatada1 (1. IMCR, Gunma Univ., 2. IMEG, Kumamoto Univ., 3. RIKEN IMS, 4. Center for Gene Res., Yamaguchi Univ.)
Comment()
11:55 AM - 12:08 PM JST(2:55 AM - 3:08 AM UTC)

[2MS-07-04]Functional dissection of the GATA2 distal enhancer using a mouse model recapitulating the human 3q21q26 inversion

○Mikiko Suzuki1,2 (1. Tohoku University Graduate School of Medicine, 2. INGEM, Tohoku University)
Comment()
12:08 PM - 12:21 PM JST(3:08 AM - 3:21 AM UTC)

[2MS-07-05]Challenges in the Treatment of Central Nervous System Diseases by Mitochondrial Transplantation

○Yuichiro Ohnishi1, Ayano Suzuki4,1, Daiki Setoyama3, Shigenobu Yonemura4,1, Masamichi Yamamoto1 (1. Research Institute, National Cerebral and Cardiovascular Center, 3. Kyushu university, 4. Tokushima University Graduate School of Medicine)
Comment()
12:21 PM - 12:34 PM JST(3:21 AM - 3:34 AM UTC)

[2MS-07-06]Generation of humanized animals via chromosome engineering technology and the application

○Yasuhiro Kazuki1 (1. Tottori University)
Comment()
12:34 PM - 12:35 PM JST(3:34 AM - 3:35 AM UTC)

Conclusion

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