The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[3AS-01]【J】Illuminating Cell Proliferation Mechanisms with Light or Chemical Manipulation

Fri. Dec 5, 2025 9:00 AM - 11:00 AM JST
Fri. Dec 5, 2025 12:00 AM - 2:00 AM UTC
Room 1(Pacifico Yokohama Conference Center 1F, Main Hall)
Organizer: Shigehiro Kawashima (The University of Tokyo), Takumi Chinen (The University of Tokyo)
During the progression of the cell cycle, the function and structure of chromosomes, microtubules, and cell membranes, as well as the modification states of proteins and nucleic acids, change rapidly and dynamically. Artificial manipulation of these processes is important not only to deepen our understanding of cell proliferation mechanisms, but also to open up new possibilities for drug discovery. This workshop will focus on cutting-edge research to elucidate the cell proliferation process using novel manipulation techniques utilizing “light" and “chemistry (compounds)". We aim to create a new platform for participants to share innovative approaches in the field and promote cross-disciplinary collaboration.
9:00 AM - 9:10 AM JST(12:00 AM - 12:10 AM UTC)

[3AS-01-01]Mitotic Phase Separation: A Novel Target for Drug Discovery

○Takumi Chinen1 (1. The University of Tokyo)
Comment()
9:10 AM - 9:25 AM JST(12:10 AM - 12:25 AM UTC)

[3AS-01-02(3P-447)]Vulnerable regulation of chromosome segregation in cancers

○Nana Kamakura1,2, Toru Hirota1,2 (1. Japanese Foundation of Cancer Research, 2. Institute of Science Tokyo)
Comment()
9:25 AM - 9:40 AM JST(12:25 AM - 12:40 AM UTC)

[3AS-01-03]A chemical genetic screen using fission yeast identifies a unique anti-microtubule drug that pauses microtubule dynamics and kinetochore-microtubule tension

○Mika Toya1,2, Mamika Minagawa1, Shigehiro Kawashima3, Masamitsu Sato1 (1. Waseda Univ., 2. Kyoto Univ., 3. Univ. of Tokyo)
Comment()
9:40 AM - 9:55 AM JST(12:40 AM - 12:55 AM UTC)

[3AS-01-04]Mechanistic diversity of oocyte spindle across mammalian species

Takaya Totsuka1, Ahmed Balboula2, ○Takashi Akera1 (1. National Institutes of Health, 2. Division of Animal Sciences, Univ. of Missouri)
Comment()
9:55 AM - 10:10 AM JST(12:55 AM - 1:10 AM UTC)

[3AS-01-05]Mechanisms of mitotic spindle assembly and interphase microtubule network organization in medaka early embryos

○Tomomi Kiyomitsu1 (1. Okinawa Institute of Science and Technology Graduate University)
Comment()
10:10 AM - 10:20 AM JST(1:10 AM - 1:20 AM UTC)

[3AS-01-06(3P-571)]Uncovering Novel Transcriptional Regulatory Mechanisms of Neural Stem Cells Using Optogenetic Tool

○Mayumi Yamada1, Itaru Imayoshi2 (1. Cell Biol, Inst Life Med Sci, Kyoto Univ., 2. Brain Dev Reg, Grad Sch Biostudies, Kyoto Univ.)
Comment()
10:20 AM - 10:30 AM JST(1:20 AM - 1:30 AM UTC)

[3AS-01-07(3P-441)]Development of an Optogenetic Tool for Controlling the Spindle Assembly Checkpoint (Opto-SAC) in Eukaryotic Cells

○Chijun An1, Yuhei Goto1, Kazuhiro Aoki1 (1. Graduate School of Biostudies, Kyoto University)
Comment()
10:30 AM - 10:40 AM JST(1:30 AM - 1:40 AM UTC)

[3AS-01-08(3P-429)]Elucidating the mechanisms regulating cell shape through photochemical manipulation

○Shohei Yamamoto1 (1. The University of Tokyo)
Comment()
10:40 AM - 10:50 AM JST(1:40 AM - 1:50 AM UTC)

[3AS-01-09(1P-387)]Precision Control of Organelles and Cellular Functions via Copper-Free DBCO–Azide Click Chemistry

○Takayuki Seki2, Kanata Itadoko2, Koutaro Shiwa3, Kazunobu Igawa3,4, Hisato Saitoh1,4,2 (1. Department of Biological Science, Graduate School of Science and Technology(GSST), Kumamoto University, 2. Faculty of Science, Biological Science, Kumamoto University, 3. Department of Chemistry, Graduate School of Science and Technology(GSST), Kumamoto University, 4. Faculty of Advanced Science and Technology (FAST), Kumamoto University)
Comment()
10:50 AM - 11:00 AM JST(1:50 AM - 2:00 AM UTC)

[3AS-01-10]Development of new technology for chemically manipulating histone modifications

○Shigehiro A. Kawashima1 (1. The Univ. of Tokyo)
Comment()
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