Session Details
[3AS-11]【J】Frontiers in pluripotent stem cell research and applications
Fri. Dec 5, 2025 9:00 AM - 11:00 AM JST
Fri. Dec 5, 2025 12:00 AM - 2:00 AM UTC
Fri. Dec 5, 2025 12:00 AM - 2:00 AM UTC
Room 11(Pacifico Yokohama Conference Center 4F, 414+415)
Organizer: Yuichiro Miyaoka (Tokyo Metropolitan Institute of Medical Science), Yohei Hayashi (Kyoto University)
Human pluripotent stem cells (PSCs) provide a platform for molecular and cellular biological experiments of human life phenomena for which in vivo experiments are not possible, and also contribute to regenerative medicine and drug discovery. This symposium will introduce the front-line research on reprogramming, genome editing, epigenome, transcriptome, proteome, disease models, and therapeutic development using human PSCs, and provide an opportunity to consider the further development of PSC research.
Introduction
[3AS-11-01]Development of disease models and novel therapies using disease-specific iPS cells
○Yohei Hayashi1 (1. CiRA Foundation)
[3AS-11-02(3P-091)]Structural and biochemical analyses of SOX2 binding to genomic sequences in nucleosomes
○Kenta Echigoya1, Yoshimasa Takizawa1, Tomoya Kujirai1,2, Mitsuo Ogasawara1, Yohei Hayashi3, Hitoshi Kurumizaka1,2 (1. Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 2. RIKEN Center for Integrative Medical Sciences, 3. Research and Development Center, CiRA Foundation)
[3AS-11-03]Understanding epigenome heterogeneity of human induced pluripotent stem cells
○Shihori Yokobayashi1 (1. RIKEN Center for Integrative Medical Sciences)
[3AS-11-04(3P-619)]Active WNT/β-Catenin signalling derails the naïve to primed state transition in human pluripotent stem cells
○Connor Ross Ross1, Takuya Azami2, Peter Rugg-Gunn3, Stefan Hoppler1 (1. Institute of Medical Sciences, University of Aberdeen, 2. Human Genetics Unit, University of Edinburgh, 3. Babraham Institute, University of Cambridge)
[3AS-11-05(3P-579)]Establishment of iPS Cells from Peripheral Blood Mononuclear Cells Using Synthetic RNAs: Efficient Reprogramming via p53 Pathway Modulation
○Masato Nakagawa1,2, Mizuho Nogi1, Hatsuki Doi1, Hirohisa Ohno1, Megumi Mochizuki1, Karin Hayashi1, Hirohide Saito1 (1. Center for iPS Cell Research and Application (CiRA), Kyoto University, 2. Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka)
[3AS-11-06(3P-575)]Dynamic rewiring of isoform switching during somatic cell reprogramming
○Satomi Masai Masai1, Yasuhiro Yunoki1, Weipeng Shi1, Yuki Sasaki1, Risa Kawaguchi1, Masato Nakagawa1 (1. Kyoto University)
[3AS-11-07]Massively parallel reporter assays reveal gene regulatory grammar
○Fumitaka Inoue1 (1. Kyoto Univ. ASHBi.)
[3AS-11-08(3P-537)]Arteriovenous Vascular Organoid Development to Investigate Angiogenic Dysregulation in Vascular Malformations Associated with Congenital Heart Disease
○Laura Yuriko González-Teshima1,2, Kozue Murata1, Masaya Hagiwara2, Hidetoshi Masumoto1 (1. Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2. Human Biomimetic System RIKEN Hakubi Research Team, RIKEN Center for Biosystems Dynamics Research, Kobe, Japan)
[3AS-11-09]Establishment and Application of Human Tetraploid iPS Cells
Ittetsu Nakajima1,2, Mitsuyoshi Shimane3, Grace Holmstrom4, ○Yuichiro Miyaoka1,2,5 (1. TMIMS, 2. Inst. of Sci. Tokyo, 3. Nanion Technologies Japan, 4. Pitzer College, 5. Ochanomizu Univ.)