Session Details
[3PS-18]【J】 New frontier in nuclear envelop: cellular and pathological functions
Fri. Dec 5, 2025 2:20 PM - 4:20 PM JST
Fri. Dec 5, 2025 5:20 AM - 7:20 AM UTC
Fri. Dec 5, 2025 5:20 AM - 7:20 AM UTC
Room 18(Pacifico Yokohama Conference Center 5F, 511+512)
Organizer: Masaru Ueno (Hiroshima University), Hisao Masai (Tokyo Metropolitan Institute of Medical Science)
Nuclear envelope (NE) plays important roles in inheritance, maintenance, repair and expression of genetic information as well as in chromatin architecture. Loss of NE integrity is known to be associated with premature aging and cancer. Repair mechanisms of NE damaged by mechanical stresses also emerge as an important issue. In this symposium, we will discuss latest development in molecular/cellular and genetic studies on mechanisms of NE integrity maintenance and in cellular and pathological outcomes of its failure. We plan to select abstracts from scientists actively working on biology of NE.
Introduction
[3PS-18-01]Analysis of the mechanism by which Diindolylmethane damages the nuclear envelope of fission yeast
○Masaru Ueno1, Kaiyu Wang 1, Hideto Nagai1, Hidenori Osawa1, Suguru Shibata1 (1. Hiroshima University)
[3PS-18-02]Inner nuclear membrane proteins for maintaining the nuclear envelope integrity and their repairing mechanisms
○Tokuko Haraguchi1, Yasuhiro Hirano1, Tatsuo Fukagawa1, Yasushi Hiraoka1 (1. Osaka University)
[3PS-18-03]Distinct Roles of Lamin A and C in Regulating Nuclear Envelope Repair and Chromatin Organization
○Yohei Kono1, Masaki Kawase2, Yoshimasa Takizawa3, Miyuki Shimazu4, Takiko Daikoku4, Yusuke Miyanari1, Takeshi Fukuma1, Hitoshi Kurumizaka3, Yoichi Shinkai2, Hiroshi Kimura5, Takeshi Shimi1 (1. WPI-NanoLSI, Kanazawa Univ., 2. Cell. Memory Lab, RIKEN, 3. Chromatin Struc.&Func, IQB, UTokyo, 4. Animal Model, ReCEMHD, Kanazawa Univ., 5. CBC, IIR, Science Tokyo)
[3PS-18-04(3P-098)]Structural analysis of nuclear lamina-associated proteins bound to nucleosomes
○Naoki Horikoshi1, Yoshimasa Takizawa1, Hitoshi Kurumizaka1 (1. The Univ. of Tokyo, IQB)
[3PS-18-05]Nuclear envelope stress and its response in vivo
○yasunao kamikawa1, Zuqian Wu1, Kazunori Imaizumi2,3 (1. Graduate School of Biomedical and Health Sciences, Hiroshima University, 2. The Osaka medical research foundation for intractable diseases, 3. United Graduate School of Child Development, Osaka University)
[3PS-18-06(3P-428)]ESCRT III-Driven Repair of Nuclear Rupture Lifts Transcriptional Arrest in Lamin-Related Cardiomyopathy
○Atsuki En1,2, Melanie Gucwa1, Cara Barnett1, Nicole Weaver1, Kohta Ikegami1 (1. Cincinnati Children's Hospital Medical Center, 2. Yokohama City Univ.)
[3PS-18-07]The Molecular Basis of Nucleus–Cytoplasm Functional Coordination
○Miki Matsumura1 (1. Ehime Prefectural University of Health Sciences)
[3PS-18-08]Regulation of Replication factors by lipid binding and lipid modification (palmitoylation)
○Hisao Masai1, Tomohiro Iguchi1, Sayuri Ito1, Mikihiro Shibata4, Asako Sakaue-Sawano2, Rino Fukatsu1, Masatoshi Takagi2, Atsushi Miyawaki2, Asami Ooji3,1, Hisashi Miura3, Kenji Moriyama1, Hiroyuki Sasanuma1 (1. Tokyo Metropolitan Institute of Medical Science, 2. RIKEN Center for Brain Science, 3. RIKEN Center for Biosystems Dynamics Research (RIKEN BDR), 4. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University)