The 48th Annual Meeting of the Molecular Biology Society of Japan
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Session Details

Symposium

[3AS-03]【J】Perturbing RNAs: Physiology and co-option mechanisms of RNAs disrupting organismal homeostasis

Fri. Dec 5, 2025 9:00 AM - 11:00 AM JST
Fri. Dec 5, 2025 12:00 AM - 2:00 AM UTC
Room 3(Pacifico Yokohama Conference Center 3F, 302)
Organizer: Yukio Kawahara (The University of Osaka), Mie Kobayashi-Ishihara (Keio University)
RNA itself can disrupt biological homeostasis, as seen with exogenous RNA from viruses and self-derived endogenous RNA that triggers immune responses. However, how these RNAs cause harm, how the body recognizes and counters them, and, at times, utilizes them for survival remain unclear. This symposium will explore the "perturbing" RNAs, their physiological impacts, and co-option mechanisms across various disciplines.
9:00 AM - 9:06 AM JST(12:00 AM - 12:06 AM UTC)

[3AS-03-01]Introduction

○Yukio Kawahara1 (1. The University of Osaka)
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9:06 AM - 9:18 AM JST(12:06 AM - 12:18 AM UTC)

[3AS-03-02]Comprehensive Identification and Characterization of Perturbing RNAs Using Open Transcriptomic Data

○Junna Kawasaki1,2,4, Jumpei Ito3, Michiaki Hamada4, Tadaki Suzuki1,2 (1. Chiba Univ., 2. NIID, 3. Tokyo Univ., 4. Waseda Univ.)
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9:18 AM - 9:30 AM JST(12:18 AM - 12:30 AM UTC)

[3AS-03-03(3P-793)]Quantifying Host Immune Responses to Viruses Using Large-Scale Animal RNA-Seq Data for Detection of Viral Infection

○Luca Nishimura1, Hiroaki Unno1, Junna Kawasaki2,3, Jumpei Ito1, Kei Sato1 (1. IMSUT, 2. Chiba Univ., 3. NIID)
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9:30 AM - 9:42 AM JST(12:30 AM - 12:42 AM UTC)

[3AS-03-04(3P-620)]Lysosome-mediated RNA degradation fosters zygotic genome activation in Drosophila

○Shiho Makino1, Yoshinori Ohsumi2, Takashi Fukaya1,3 (1. Institute for Quantitative Biosciences, The University of Tokyo, 2. Cell Biology Center, Institute of Innovative Research, Institute of Science Tokyo, 3. Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo)
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9:42 AM - 10:00 AM JST(12:42 AM - 1:00 AM UTC)

[3AS-03-05]Immune Regulation by the Decay of Perturbing RNAs

○Osamu Takeuchi1 (1. Kyoto Univ.)
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10:00 AM - 10:18 AM JST(1:00 AM - 1:18 AM UTC)

[3AS-03-06]Characterization of mRNAs that perturb translation in zebrafish

○Yuichiro Mishima1 (1. Kyoto Sangyo University)
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10:18 AM - 10:30 AM JST(1:18 AM - 1:30 AM UTC)

[3AS-03-07(3P-788)]Study on the Regulation of Neuronal Tropism by Non-Coding Regions of the Viral Genome RNA

○Kyousuke Kobayashi1, Tomaha Nishizawa1, Masako Ukaji1, Satoshi Koike1 (1. Tokyo Metropolitan Institute of Medical Science)
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10:30 AM - 10:48 AM JST(1:30 AM - 1:48 AM UTC)

[3AS-03-08]Physiological roles of Long Interspersed Nuclear Elements in brain development

○Tomohisa Toda1,2 (1. Friedrich-Alexander Universität Erlangen-Nürnberg, 2. Max-Planck-Zentrum für Physik und Medizin)
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10:48 AM - 11:00 AM JST(1:48 AM - 2:00 AM UTC)

[3AS-03-09]Discovery of REFEE: A Factor Facilitating perturbing RNA Co-option and its Role in Mouse Early Embryonic Development

○Mie Kobayashi-Ishihara1,2, Akihiko Sakashita2,3, Youjia Guo2, Hirotsugu Ishizu6,2, Hidetoshi Hasuwa4, Hidetaka Kosako5, Kensaku Murano2, Haruhiko Siomi6,2 (1. The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center, 2. Department of Molecular Biology, Keio University School of Medicine, , 3. Riken Bioresource Research Center , 4. Laboratory Animal Center, Keio University School of Medicine, 5. Fujii Memorial Institute of Medical Sciences, Tokushima University, 6. Next Generation In Vivo Research Center, Chiba University)
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