Session Details
[3PS-08]【J】Epigenetic regulation controls development and disease onset
Fri. Dec 5, 2025 2:20 PM - 4:20 PM JST
Fri. Dec 5, 2025 5:20 AM - 7:20 AM UTC
Fri. Dec 5, 2025 5:20 AM - 7:20 AM UTC
Room 8(Pacifico Yokohama Conference Center 3F, 315)
Organizer: Hideyuki Takeshima (Hoshi University), Hisanori Takenobu (Saitama Cancer Center)
Epigenome is essential for the formation of our bodies and plays important roles in various life phenomena. On the other hand, our epigenome is aberrantly re-written by various external factors, and the accumulation of such alterations leads to the development of diseases, such as cancers. In this symposium, we will focus on the epigenome and its regulators, and discuss the molecular mechanisms by which they are involved in the tissue development and disease onset.
Introduction
[3PS-08-01]Molecular pathogenesis underlying imprinting disorders linked to defective cytoplasmic lattice formation in oocytes
○Motoko Unoki1 (1. The University of Tokyo)
[3PS-08-02(3P-094)]DPPA3 interacts with the UHRF1 SRA domain via zinc-coordination and inhibits hemimethylated DNA binding of UHRF1
○Ayana Ota1, Shota Tanimoto1, Christopher B. Mulholland3, Yoshie Chiba1, Kyohei Arita2, Heinrich Leonhardt3, Atsuya Nishiyama1, Makoto Nakanishi1 (1. Div. Cancer Cell Biol., Inst. Med. Sci., Univ. Tokyo, 2. Grad. Sch. Med. Life Sci., Yokohama City Univ., 3. Fac. Biol. & Ctr. Mol. Biosyst. (BioSysM), Human Biol. & BioImaging, LMU Munich)
[3PS-08-03(3P-102)]Histone H3K27 mono-methylation by PRC2 complex and G9a/GLP in mammalian cells
○Yuto Iwaya1,2, Ayumi Yamada1, Yoichi Shinkai1 (1. RIKEN, Shinkai cellular memory laboratory, 2. Institute of Science Tokyo)
[3PS-08-04]Integrative Analysis of Drug Actions and Disease Mechanisms Using ChIP-Atlas
○Zhaonan Zou1, Shinya Oki1 (1. Kumamoto University)
[3PS-08-05]Synthetic lethality targeting aberrant DNA methylation
○Hideyuki Takeshima1, Yui Ohashi1, Toshikazu Ushijima1 (1. Hoshi University)
[3PS-08-06(3P-678)]Elucidation of epigenetic changes underlying axon regeneration in a hypoglossal nerve injury model
○Yudai Nishiyama1,2, Sumiko Kiryu3, Yusuke Kishi1,2 (1. Institute for Quantitative Biosciences in The University of Tokyo, 2. Graduate School of Pharmaceutical Sciences in The University of Tokyo , 3. Nagoya University Graduate School of Medicine)
[3PS-08-07(3P-113)]Nucleosome stability safeguards cell identity and stress resilience and promotes healthy aging
○Hiroshi Tanaka1, Brenna McCauley2, Clara Guida1, Sha Li1, Xue Lei1, Weiwei Dang2, Michael Petrascheck3, Rolf Bodmer1, Peter Adams1 (1. Sanford Burnham Prebys Medical Discovery Institute (USA), 2. Baylor College of Medicine, 3. The Scripps Research Institute)
[3PS-08-08]Epigenetic drivers of pancreatic cancer progression through interaction with stromal cells
○Keiko Shinjo1, Xingxing Wang1, Kohei Kumegawa2, Reo Maruyama2, Shinji Mii4, Yoshiteru Murofushi1, Miho Suzuki1, Atsushi Enomoto3, Yutaka Kondo1 (1. Nagoya University, 2. Japanese Foundation for Cancer Research, Japan, 3. NAGOYA UNIVERSITY, 4. Hiroshima University)
[3PS-08-09(3P-723)]Analysis of Mitochondrial Dysfunction Induced by MBD5 and MBD6 Deficiency
○Shin-ichi Horike1, Keiko Iwata3, Yoko Hashimoto1, Hideo Matsuzaki2, Makiko Meguro1 (1. Kanazawa Univ., 2. Fukui Univ., 3. Wakayama Med Univ.)
[3PS-08-10]Developing novel cancer therapies by targeting epigenetic molecules, including polycomb PRC2
○Hisanori Takenobu1, Yuki Endo2,1, Dilibaerguli Shaliman1,3, Miki Ohira1, Ryuichi P Sugino1, Masayuki Haruta1, Shunpei Satoh1, Jesmin Akter1, Tomoko Wada1, Atsuko Nakazawa4, Takehiko Kamijo1,3 (1. RICO, Saitama Cancer Center, 2. Dept. Pediatric Surgery, Tohoku Univ., 3. Dept. Science and Engineering, Saitama Univ., 4. Dept. Clinical Research, Saitama Children's Medical Center)