Presentation Information
[2P-084]Usability of human immortalized cell-based blood-brain barrier spheroid model for evaluation of macromolecular drug permeability via receptor-mediated transcytosis
*Hanae Morio1, Keita Kitamura1,2, Ayaka Okamoto1, Ryo Ito3, Yoshiyuki Yamaura4, Takafumi Komori5, Tomomi Furihata1 (1. Lab. Clin. Pharm. & Exp. Therap., Sch. Pharmacy., Tokyo Univ. Pharm. & Life Sci., 2. Lab. DDS Design & Drug Dispos., Grad. Sch. Pharm. Sci., Chiba Univ., 3. Res. Ctr. Neurol., Ono Pharm. Co., Ltd., 4. Dept. Pharmacokinet. Res., Ono Pharm. Co., Ltd., 5. Dept. Drug Metab. & Pharmacokinet., Eisai Co. Ltd.)
Keywords:
Blood-brain barrier,In vitro BBB model,Receptor-mediated transcytosis,Transferrin receptor
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