[2P] A. Neural Excitability, Synapses, and Glia: Cellular Mechanisms | NEURO2022

Session Details

Poster

[2P]A. Neural Excitability, Synapses, and Glia: Cellular Mechanisms

Fri. Jul 1, 2022 11:00 AM - 12:00 PM JST
Fri. Jul 1, 2022 2:00 AM - 3:00 AM UTC

Poster Session Hall 2 Ginowan City Gymnasium

[2P-001]Calbindin-positive neurons co-express functional markers in a location-dependent manner within the A11 region of the rat brain

*Tsuyoshi YAMAGUCHI¹, Hidechika OZAWA², Shigeki YAMAGUCHI², Shinsuke HAMAGUCHI², Shuichi UEDA¹, Nobuko TOKUDA¹ (1. Dokkyo Med Univ, Dept. of Anat., Tochigi, Japan, 2. Dokkyo Med Univ, Dept. of Anesth. and Pain Med., Tochigi, Japan)

[2P-002]L-DOPA promotes neurogenesis in the Hippocampus via its receptor, GPR143.

*Yuka Kasahara^1,2, Daiki Masukawa², Kenta Kobayashi³, Miwako Yamasaki⁴, Masahiko Watanabe⁴, Yoshio Goshima² (1. Kyushu University, 2. Yokohama City University, 3. National Institute for Physiological Sciences, 4. Hokkaido University)

[2P-003]Analysis of the regulation mechanism of the tyrosine hydroxylase protein levels by intracellular dopamine concentration

*Rina Aida¹, Nanako Sugiyama¹, Satoshi Hara¹, Hiroshi Ichinose¹ (1. Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Tokyo, Japan)

[2P-004]Syt7 is the primary Ca²⁺ sensor for phasic somatodendritic DA release

*Takuya Hikima¹, Paul Witkovsky¹, Margaret E Rice^1,2 (1. Dept Neurosurgery, NYU School of Medicine, New York, USA, 2. Dept Neurosci and Physiol, NYU School of Medicine, New York, USA)

[2P-005]Among 58 clustered protocadherin (cPcdh), PcdhγC4 is an essential isoform for mice survival.

*Ryuon Higuchi¹, Haruka Umezawa¹, Akira Hagi¹, Masahiko Watanabe², Makoto Sanbo³, Masumi Hirabayashi³, Takeshi Yagi¹ (1. Grad Sch Front. Biosci, Osaka Univ, 2. Grad Sch Med, Hokkaido Univ, 3. Cent for Gen Analy of Behav, Natio Insti for Physi Sci)

[2P-006]Characterization of double-positive glutamatergic and GABAergic neurons in the gigantocellular reticular nucleus in the brainstem.

*Tomoki Osuka¹, Hiroaki Wake³, Etsuo Susaki^4,2, Katsuhiko Matsumoto², Takeshi Yagi¹ (1. Grad Sch FBS, Univ of Osaka, Osaka, Japan, 2. Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Osaka, Japan, 3. Grad Sch Med, Univ of Nagoya,Nagoya, Japan, 4. Grad Sch Med, Univ of Juntendo, Tokyo, Japan)

[2P-007]Exploration of C-terminal specific sequences involved in the intracellular trafficking of mGluR6

*Atsushi Shimohata¹, Takumi Akagi¹, Ikuo Ogiwara¹, Makoto Kaneda¹ (1. Dept Physiol, Nippon Med Sch, Tokyo, Japan)

[2P-008]Effect of Extracellular Tau on AMPAR and GABA_AR clusters

*Ayano Machida¹, Shigeo Sakuragi¹, Yoshiyuki Soeda², Akihiko Takashima², Hiroko Bannai¹ (1. Grad Sch of Advanced Science and Engineering, Univ of Waseda, Tokyo, Japan, 2. Faculty of Science, Univ of Gakushuin, Tokyo, Japan)

[2P-009]mGluR5 is substitutable for mGluR1 in cerebellar Purkinje cells for motor coordination and developmental synapse pruning

*Maria Harbers¹, Harumi Nakao¹, Takaki Watanabe², Yasushi Kishimoto³, Masanobu Kano², Atsu Aiba¹ (1. Lab Animal Resources, CDBIM, Grad Sch Med, Univ of Tokyo, Tokyo, Japan, 2. Department of Neurophysiology, Grad Sch Med, Univ of Tokyo, Tokyo, Japan, 3. Faculty of Pharma-science, Teikyo University, Tokyo, Japan)

[2P-010]Expression and functional regulation of equilibrative nucleoside transporters in cultured astrocytes

*Koh-ichi Tanaka^1,2,3, Takuto Izawa¹, Yuri Kodama¹, Wataru Suzuki¹, Kazuo Tomita^2,1, Kento Igarashi^2,1, Nobue Kitanaka³, Junichi Kitanaka^1,3, Tomoaki Sato², NobuyoshiNishiyama Nishiyama¹ (1. Dept Pharmacy, Hyogo Col Med, Hyogo, Japan, 2. Grad Sch Med & Dent Sci, Kagoshima Univ, Kagoshima, Japan, 3. Dept. Med, Hyogo Col Med, Hyogo, Japan)

[2P-011]Analysis of the mechanism regulating localization of G protein-coupled receptors to primary cilia

*KO MIYOSHI^1,2, YINSHENGZHUOMA WANG¹, YUANYUAN QIN¹, TAKESHI YOSHIMURA¹, TAIICHI KATAYAMA¹ (1. Dept of Child Develop and Molecular Bra Sci, United Grad Sch of Child Develop, Osaka Univ, Suita, Japan, 2. Molecular Res Center for Child Mental Develop, United Grad Sch of Child Develop, Osaka Univ, Suita, Japan)

[2P-012]Dynamics of NMDA receptor subunit proteins in mouse brain

*Kenji Sakimura¹, Yasuhiro Suzuki¹, Chihiro Nakamoto¹, Masahiko Watanabe², Toshikuni Sasaoka¹, Manabu Abe¹ (1. Brain Res Inst, Niigata Univ, Niigata, Japan, 2. Hokkaido Univ Grad Sch Med, Sapporo, Japan)

[2P-013]Human induced pluripotent stem cell-derived neural cells were protected from excitotoxicity induced by high concentration of L-glutamate through the functions of EAAT1 and 2

*kanako TAKAHASHI¹, Kaori Chujyo¹, Ikuro Suzuki², Kaoru Sato¹ (1. Lab. Neuropharmacol., Div. Pharm., Nat. Inst. Hlth. Sci., Kanagawa, Japan, 2. Dept. Electronics, Grad. Sch. Engineering, Tohoku Inst. Tech., Miyagi, Japan)

[2P-014]Peripheral nerve injury facilitates burst firing of thalamocortical neurons via GABAergic tonic inhibition dependent on microglial activity

*Yoshifumi Ueta¹, Mariko Miyata¹ (1. Tokyo Women's Med Univ)

[2P-015]Changes in action potential properties of striatal cholinergic interneurons during development and aging.

*Etsuko Suzuki¹, Toshihiko Momiyama¹ (1. Jikei University, Sch. of Med. Dept. Pharmacology)

[2P-016]Examining the in vivo neural network activity of a Scn2a loss-of-function mouse model

*Melody Li¹, Bernd Kuhn¹ (1. Okinawa Institute of Science and Technology )

[2P-017]Essential Role of Somatic Kv2 Channels in High-
Frequency Firing in Cartwheel Cells of the Dorsal
Cochlear Nucleus

*Tomohiko Irie¹ (1. National Institute of Health Sciences)

[2P-018]Oxidation sensitizes TRPV2 to chemical and heat stimuli, but not mechanical stimulation

*Koji Shibasaki¹, Isaki Hanamura¹ (1. Laboratory of Neurochemistry, Graduate School of Human Health Science, University of Nagasaki)

[2P-019]Nanoscale computational modeling explains why evolutionary shift happened

*Alexey Martyushev¹, Erik De Schutter¹ (1. Okinawa Institute of Science and Technology Graduate University (OIST))

[2P-020]Quantitative analysis of nanoscale phosphoinositide distribution on neuronal cell membranes of mouse cerebellum

*Kohgaku Eguchi¹, Ryuichi Shigemoto¹ (1. IST Austria, Klosterneuburg, Austria)

[2P-021]Insights into the interaction of voltage-gated sodium channel Nav1.1 with fibroblast growth factor homologous factors

*Ikuo Ogiwara¹, Chengzhu Yin¹, Atsushi Shimohata¹, Mie Gangi¹, Matoko Kaneda¹ (1. Nippon Medical School)

[2P-022]Analysis of interacting proteins of the voltage-gated sodium channel Nav1.2

*Haruko Miyazaki^1,2, Nobuyuki Nukina² (1. Okayama University, 2. Doshisha University)

[2P-024]Actin filaments restrict synaptic vesicle movement for rapid tethering of vesicles at a fast central synapse

*Takafumi Miki¹, Rio Toyofuku², Takeshi Sakaba¹ (1. Grad Sch Brain Science, Doshisha University, Kyotanabe, Japan, 2. Faculty of Life and Medical Science, Doshisha Universitu)

[2P-025]Spontaneously recycling synaptic vesicles constitute readily releasable vesicles in zebrafish neuromuscular synapses

*Yoshihiro Egashira¹, Ayane Kumade², Akio Ojida², Fumihito Ono¹ (1. Grad Sch Med, Osaka Med Pharm Univ, Takatsuki, Japan, 2. Grad Sch Pharm, Kyushu Univ, Fukuoka Japan)

[2P-026]Development of the correlative technique for analyzing cortical pyramidal neurons with in vivo two-photon and expansion microscopy

*Yutaro Kashiwagi¹, Masaaki Endo¹, Hiroshi Terashima¹, Shige Okabe¹ (1. Grad Sch Med, Univ of Tokyo, Tokyo, Japan)

[2P-027]Analysis of primary cultured neurons treated with drebrin inhibitor BTP2

*Nagisa Fujise¹, Yuko Sekino², Tomoaki Shirao³, Nobuhiko Kojima⁴ (1. Grad Sch Life science, Univ of Toyo, Gunma, Japan, 2. Grad Sch Pharmaceutical Sciences, Univ of Tokyo, Tokyo, Japan, 3. AlzMed, Inc. Tokyo, Japan, 4. Grad Sch Life science, Univ of Toyo, Gunma, Japan)

[2P-029]Baclofen attenuates activities of caffeine-induced neural oscillations in the somatosensory cortex of rat

*Hiroyuki Kanayama^1,2, Takako Fukuda¹, Takashi Tominaga³, Yoko Tominaga³, Nobuo Kato⁴, Hiroshi Yoshimura¹ (1. Department of Molecular Oral Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 2. National Hospital Organization Osaka National Hospital, Oral and Maxillofacial Surgery, 3. Institute of Neuroscience, Tokushima Bunri University, 4. Department of Physiology, Kanazawa Medical University)

[2P-030]Function of GluD1-Cbln1 complex in thalamocortical synapse which implements flexible behavior

*Mari Shiozaki¹, Ayako Wendy Ishikawa¹, Shintaro Otsuka¹, Aya Ito-Ishida¹, Michisuke Yuzaki¹ (1. Grad Sch Med, Univ of Keio, Tokyo, Japan)

[2P-031]Development and validation of Arc nanobodies: new tools for probing Arc dynamics and function

*Yuta Ishizuka^1,5, Tadiwos F. Mergiya^1,2, Rodolfo Baldinotti^1,2, Ju Xu¹, Erik I. Hallin¹, Sigurbjörn Markússon¹, Petri Kursula^1,3,4, Clive R. Bramham^1,2 (1. Dept Biomed, Univ of Bergen, Bergen, Norway, 2. Mohn Ctr for Res on the Brain, Univ of Bergen, Bergen, Norway, 3. Fac Biochem & Mol Med, Univ of Oulu, Oulu, Finland, 4. Biocenter Oulu, Univ of Oulu, Oulu, Finland, 5. Dept Pathophysiol & Metab, Kawasaki Med Sch, Kurashiki, Okayama)

[2P-032]C1ql1-Bai3 signaling regulates synaptic connectivity of climbing fiber branches in adult cerebellum

*Takahiro Aimi¹, Michisuke Yuzaki¹ (1. Keio University Graduate School of Medicine, Tokyo, Japan)

[2P-033]Functional organization of motor cortical circuitry for learning

*Takeshi Otsuka¹, Yasuo Kawaguchi² (1. Section of Cellular Electrophysiology, National Institute for Physiological Sciences, 2. Brain Science Institute, Tamagawa University)

[2P-034]Biophysical analysis of cannabinoids-mediated modulation of synaptic vesicle exocytosis by direct patch-clamp recordings

*Takuma Inoshita¹, Shin-ya Kawaguchi¹ (1. Kyoto University)

[2P-035]Identification of interactions between Munc13-1 and other active zone proteins vital for the formation of synaptic vesicle release sites

*Yusuke Kojima¹, Hirokazu Sakamoto¹, Shigeyuki Namiki¹, Kenzo Hirose¹ (1. Grad Sch Med, Univ of Tokyo, Tokyo, Japan)

[2P-036]Depolarization-induced long-term potentiation at supramammillary-dentate granule cell synapses

*Yuki Hashimotodani¹, Eri Tabuchi¹, Takeshi Sakaba¹ (1. Graduate School of Brain Science, Doshisha University)

[2P-037]Effects of chronic administration of fingolimod hydrochloride (FTY720) on parvalbumin immunoreactivities in the mouse hippocampus

*Hiroshi Ueno¹, Yu Takahashi², Motoi Okamoto³, Takeshi Ishihara² (1. Kawasaki Univ of Med Welf, Okayama, Japan, 2. Kawasaki Medical School, Okayama, Japan, 3. Okayama University, Okayama, Japan)

[2P-038]Stochastic spatial modeling of vesicle-mediated trafficking of AMPA receptors for understanding hippocampal synaptic plasticity mechanisms

*Sarah Yukie Nagasawa¹, Iain Hepburn¹, Andrew R. Gallimore¹, Erik De Schutter¹ (1. Okinawa Institute of Science and Technology Graduate University)

[2P-039]Dynamic mechanisms of cholinergically modulated synaptic plasticity in the hippocampal CA1 area

*Eriko Sugisaki¹, Yasuhiro Fukushima², Takeshi Aihara¹ (1. Tamagawa University, Tokyo, Japan, 2. Kawasaki University of Medical Welfare, Okayama, Japan)

[2P-040]Gradual acceptor photobleaching reveals the interactability of B-type GABA receptor with type-1 metabotropic glutamate receptor

*Kengo Kirinoki¹, Takuya Mori², Taito Takahashi², Yuji Kamikubo³, Hakushun Sakairi³, Takashi Sakurai³, Toshihide Tabata⁴ (1. Grad Sch Sci Eng, Univ of Toyama, Toyama, Japan, 2. Grad Sch Pharma-Med Sus, Univ of Toyama, Toyama, Japan, 3. Juntendo Univ Fac Med, Tokyo, Japan, 4. Fac Eng, Univ of Toyama, Toyama, Japan)

[2P-041]Optical inactivation technology for GluA2/3 AMPA receptor.

*Susumu Jitsuki^1,2, Takuya Takahashi², Kiwamu Takemoto¹ (1. Grad Sch Med, Mie University, 2. Grad Sch Med, Yokohama City University)

[2P-042]Heterosynaptic spine structural plasticity across dendritic branches

*Thomas Chater¹, Yukiko Goda^1,2 (1. RIKEN, Japan, 2. OIST, JAPAN)

[2P-043]Molecular plasticity in dendritic spines in vivo

*Maki K. Yamada^1,2, Kazuya Kuboyama^1,4, Takeshi Kubota^1,2, Miku Yoshioka¹, Otoha Nakatani¹, Toshie Fujishima³, Shungo Adachi⁵, Tohru Natsume⁵ (1. Neuropharmacol, Kagawa Pharma Sci, Tokushima Bunri Univ, Kagawa, Japan, 2. Neuropharmacol, Inst Neurosci, Tokushima Bunri Univ, 3. Med Chem, Kagawa Pharma Sci, Tokushima Bunri Univ, 4. Dev Regen Neurobio, Inst Brain Sci, Grad Sch Med, Nagoya City Univ, 5. Cell Mol Biotech Res Inst, AIST)

[2P-044]Mechanism of the long-lasting antidepressant action of ketamine

*Daisuke Okada^1,2, Fuminari Amano¹, Kenji Mandai^1,2 (1. Kitasato University, Grad Sch Med Sciences, Sagamihara, Japan, 2. Kitasato Univ, Sagamihara, Japan )

[2P-045]Methamphetamine-induced remodelling of hippocampal neurons is orchestrated via cdc42 pathway

*Ana Filipa Terceiro^1,2, Andrea Lobo¹, Lia Carvalhais^3,4, Miguel Aroso⁵, Mafalda Sousa⁶, Ana Magalhães¹, Paulo Aguiar⁵, João Relvas^7,8, Teresa Summavielle^1,9 (1. Addiction Biology Group, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, 2. Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal, 3. Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, 4. Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal, 5. Neuroengineering and Computational Neuroscience, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, 6. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, 7. Glial Cell Biology, i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal, 8. Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal, 9. ESS.PP, Escola Superior de Saúde do Politécnico do Porto, Porto, Portugal)

[2P-046]Associative responces for inputs to hippocampal granule cell

*kazuhisa kamei¹, Tadayosi Monden¹, Eriko Sugisaki², Naoki nakajima¹, Ryoutarou Koike¹, Takesi Aihara² (1. Tamagawa University Graduate School of Engineering, 2. Tamagawa University)

[2P-047]Distinct modulation of excitatory and inhibitory synaptic inputs in hippocampal neuronal dendrites

*Masato Morita¹, Shin-ya Kawaguchi¹ (1. Dept Biophys, Grad Sch Sci, Kyoto Univ, Kyoto, Japan)

[2P-048]The expression pattern of alternative splicing variant of Sez6 in mouse brain

*Chiharu Hidaka¹, Shinichi Mitsui², Yoji Osako¹, Kou Takahashi¹, Kenjiro Tanaka¹, Kazunari Yuri¹ (1. Department of Neurobiology and Anatomy, Kochi Medical School, Kochi University, Kochi, Japan, 2. Department of Rehabilitation Science, Gunma University Graduate School of Health Science, Gunma, Japan)

[2P-049]A study of molecular mechanism for the axonal transport employing the Tau protein as a model cargo

*Rinaho Nakata¹, Hiroaki Misonou¹ (1. Graduate School of Brain Science, Doshisha University)

[2P-050]Active TC10 on vesicles promotes axon outgrowth by stabilizing microtubules through the specific phosphorylation pathway

*Shingo Koinuma¹, Misa Miyaji¹, Akira Hoshina^1,2, So Maezawa², Naoyuki Wada², Hiroshi Takemura², Yoshiki Koriyama³, Sumiko Kiryu-Seo⁴, Hiroshi Kiyama⁴, Michihiro Igarashi⁵, Takeshi Nakamura¹ (1. RIBS, Tokyo Univ of Sci, Chiba, Japan, 2. Faculty of Sci and Tech, Tokyo Univ of Sci, Chiba, Japan, 3. Faculty of Pharm Sci, Suzuka Univ of Med Sci, Mie, Japan, 4. Grad Sch of Med, Nagoya Univ, Aichi, Japan, 5. Grad Sch of Med and Dental Sci, Niigata Univ, Niigata, Japan)

[2P-051]Analysis of microtubule stability in neurons

*Takayuki Imai¹, Tomohiro Miyasaka¹, Hiroaki Misonou² (1. Department of Neuropathology, Doshisha University, Kyoto, Japan, 2. Graduate School of Brain Science, Doshisha University, Kyoto, Japan)

[2P-052]Teneurin-2 at Synapse construction site is a signpost for protein accumulation

*Sotaro Ichinose¹, Hirohide Iwasaki¹ (1. Gunma University Graduate School of Medicine)

[2P-053]p53-independent regulation of astrocyte proliferation mediated by ER-resident transcription factor OASIS activated by DNA damage

*Atsushi Saito¹, Yasunao Kamikawa¹, Kazunori Imaizumi¹ (1. Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima University)

[2P-054]Reduced proliferative capacity and altered levels of secreted substances in calcineurin-deficient enteric glial cells in relation to the dysfunction and inflammation of the small intestine

*Masahiko Tanaka¹, Hikaru Teramoto¹, Naohide Hirashima¹ (1. Dept Cell Biophys, Grad Sch Pharmaceut Sci, Nagoya City Univ, Nagoya, Japan)

[2P-055]Impaired GABAergic synaptic transmission was caused by loss of syntaxin1B in glial cells

*Takefumi Kofuji¹, Tatsuya Mishima², Ayako Saito², Tomonori Fujiwara^2,3 (1. RI Lab, Kyorin Univ Sch Med, 2. Dept Med Physiol, Kyorin Univ Sch Med, 3. Sch Med Tech, Fac Health Med Care, Saitama Med Univ)

[2P-056]Functional evaluation of iPSC-derived astrocytes generated by a rapid differentiation method

*Yuina Wada¹, Rie Yamoto¹, Manabu Seo², Toshihiko Hosoya¹ (1. Biomedical Research and Development Department, Biomedical Business Center, RICOH Futures BU, Ricoh Company, Ltd., Kanagawa, Japan, 2. Elixirgen Scientific, Inc., Baltimore, USA)

[2P-057]A neural circuit formation factor LOTUS regulates amyloid-β protein-induced activation states in microglia.

*Ami Inoue¹, Junpei Matsubayashi¹, Yuki Kawaguchi¹, Kohtaro Takei¹ (1. Molecular Medical Bioscience Laboratory, Yokohama City University Graduate School of Medical Life Science, Yokohama, Japan)

[2P-058]Brain immune mechanisms against exogeneous nanoparticles

*Ari Ogaki¹, Yuji Ikegaya^1,2,3, Ryuta Koyama^1,3 (1. Grad Sch Pharmaceut Sci, Univ Tokyo, Tokyo, Japan, 2. Institute for AI and Beyond, Univ Tokyo, Tokyo, Japan, 3. Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan)

[2P-059]Exploring prefrontal cortex astrocytic contributions to neural circuits

*Bolati Wulaer¹, Jun Nagai¹ (1. RIKEN Center for Brain Science Laboratory for Glia-Neuron Circuit Dynamics)

[2P-060]Functional interaction between CX3CR1 and SIRPα in microglia

*Takeshi Imai¹, Asuka Tomiyama¹, Rui Mizutani¹, Sayoko Matsushita¹, Ayako Morita¹, Eriko Urano¹, Daiki Jingu¹, Yuriko Hayashi², Takashi Matozaki³, Hiroshi Ohnishi¹ (1. Gunma University Graduate School of Health Sciences, 2. Gunma Paz University Graduate School of Health Sciences, 3. Kobe University Graduate School of Medicine)

[2P-061]Delayed Reduction of Excitatory Synapses in CA3 following Systemic Inflammation

*Tatsuya Manabe^1,2, Ildiko Racz^1,2, Stephanie Schwartz^1,2, Francesco Santarelli², Julius V. Emmrich³, Jonas J. Neher^4,5, Michael T. Heneka^1,2,6 (1. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn Medical Center, Bonn, Germany, 2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 3. Department of Neurology and Experimental Neurology, Charite – Universitatsmedizin Berlin, Berlin, Germany, 4. Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany, 5. German Center for Neurodegenerative Diseases (DZNE), Tubingen, Germany, 6. Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA)

[2P-062]Analysis of exosomes released from a glial progenitor cell-line after induction of oligodendrocyte differentiation

*Kenji Ono¹, Yuka Ito¹, Kazuya Ohashi¹, Hiromi Suzuki¹, Makoto Sawada¹ (1. Res Inst Env Med, Nagoya Univ, Aichi, Japan)

[2P-063]Gene expression analysis of microglia-specific SIRPα knockout mice exhibiting improved age-related motor learning disability

*Rui Mizutani¹, Asuka Tomiyama¹, Takeshi Imai¹, Sayoko Matsushita¹, Ayako Morita¹, Eriko Urano¹, Miho Sato-Hashimoto², Yuriko Hayashi³, Takashi Matozaki⁴, Hiroshi Ohnishi¹ (1. Gunma Univ Grad Sch Health Sci, Gunma, Japan, 2. Sch Pharm Sci, Kyushu Univ Health Welfare, Miyazaki, Japan, 3. Gunma Paz Univ Grad Sch Health Sci, Gunma, Japan, 4. Kobe Univ Grad Sch Med, Kobe, Japan)

[2P-064]Morphological changes of astrocytes along the cortical depth by hypoxic adaptation

*Yota Noda¹, Tomohiro Nishino², Sosuke Tanaka¹, Kazuto Masamoto¹, Yoichi Miyawaki¹ (1. Graduate School of The University of Electro-Communications, Tokyo, Japan, 2. The University of Electro-Communications, Tokyo, Japan)

[2P-065]Time- and area-specific dynamics of glial cells during postnatal development of the monkey cerebral cortex.

*Tomoko Yamanaka¹, Emiko Tanaka¹, Masahiko Takada¹, Kenichi Inoue¹ (1. Primate research institute, Kyoto university, Aichi, Japan)

[2P-066]Involvement of NFκB in the induction of inflammatory cytokines in microglia

*Kazuyuki Nakajima¹, Takashi Ishijima¹ (1. Soka University)

[2P-067]Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation

*Hinami Asano¹, Atuyohsi Shimada², Sanae Ishii² (1. Grad Sch Health Sci, Kyorin Univ, Tokyo, Japan, 2. Fac Health Sci, Kyorin Univ, Tokyo, Japan)

[2P-068]Analysis of neuron-glia interactions by optogenetics and calcium imaging in ascidian larvae

*Nanako Okawa¹, Kazuki Yasuda², Michina Taniguchi², Haruka Motomura¹, Misaki Okahata^1,2, Atsushi Kuhara^1,2, Takehiro G. Kusakabe^1,2 (1. Graduate School of Natural Science, Konan university, 2. Inst. for Inte. Neurobiol., Dept. of Biol., Konan Univ., Kobe, Japan)

[2P-069]Effect of sphingosine kinase 1 inhibition on sphingolipid metabolic pathway and inflammatory responses in microglia

*Tomoki minamihata Minamihata¹, Katsura Takano¹, Mitsuaki Moriyama¹ (1. Osaka Prefecture University)

[2P-070]Significant increase of PKC-phosphorylated L-MPZ in peripheral myelin formation

*Yoshihide Yamaguchi¹, Hiroka Okamoto¹, Takuma Sugimoto¹ (1. Sch of Pharm, Tokyo Univ of Pharm and Life Sci, Hachioji, Japan)

[2P-071]Glial cell-type specific inflammation in Toll-like receptor 7 agonist-induced mouse model for systemic lupus erythematosus

*Ritsuko Shimogawa¹, Akira Sobue^1,2, Okiru Komine¹, Ayaka Ito^3,4, Takayoshi Suganami³, Koji Yamanaka¹ (1. Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, 2. Medical Interactive Research and Academia Industry Collaboration Center, Research Institute of Environmental Medicine, Nagoya University, 3. Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 4. Institute for Advanced Research, Nagoya University)

[2P-072]Role of astrocyte APLPs on astrocyte/synapse interaction and synaptic plasticity

*Margaux Saint-Martin¹, Yukiko Goda¹ (1. RIKEN, CBS, Wako, Japan)

[2P-073]Forelimb reaching exercise after intracerebral hemorrhage causes better motor function recovery with adaptive cerebellar oligodendrogenesis in rats

*Takeshi Shimizu¹, Aoi Sato¹, Mitsuki Kokuryoh¹, Shinya Ueno¹, Kenta Kobayashi^2,3, Hideki Hida¹ (1. Department of Neurophysiology and Brain Science, Graduate School of Medical Sciences, Nagoya City University, 2. Section of Viral Vector Development, National Institute for Physiological Sciences, 3. Graduate University of Advanced Studies (SOKENDAI))

[2P-074]Spatiotemporal divergence of microglial Ca²⁺ activity

*Hiroshi Horiuchi¹, Junko Ishida¹, Junichi Nabekura¹ (1. National Institute for Physiological Sciences)

[2P-075]Glutamine synthetase expression in astrocytes is regulated by Hippo-YAP signaling pathway

*Yusuke Nasu¹, Mamiko Imai², Nozomi Yokoyama², Miho Terunuma¹ (1. Grad Sch Med Dent Sci, Niigata Univ, Niigata, Japan, 2. Facl Dent, Niigata Univ, Niigata, Japan)

[2P-076]Peripheral pseudoviral infection-induced regional neuroinflammation responsible for fatigue symptoms in rats: A [¹⁸F]DPA-714 PET study

*Yuta Ochi¹, Wakiko Arakaki², Di Hu¹, Danxi Li¹, Mika Shigeta¹, Emi Hayashinaka³, Yasuhiro Wada³, Hisashi Doi², Yasuyoshi Watanabe³, Yilong Cui¹ (1. Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, 2. Laboratory for Labeling Chemistry, RIKEN Center for Biosystems Dynamics Research, 3. Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research)

[2P-077]Substrate preference of fatty acid oxidation in murine astrocytes in vitro

*Laarni Grace Corales¹, Hitoshi Inada^1,2, Noriko Osumi¹ (1. Department of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, 2. Laboratory of Health and Sports Sciences, Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering)

[2P-078]Sensory Glia Detect Repulsive Odorants and Drive Olfactory Adaptation

*Xiaomin Yue¹ (1. Zhejiang University)

[2P-079]Astrocytic inward rectifying K+ channels 4.1 subtype modulate glutamate release probability and LTP at individual CA3-CA1 synapses

*Olga Tiurikova^1,2, Olga Kopach ¹, Dmitri Rusakov¹ (1. University College London, 2. Institute of Bioorganic Chemistry, Russia)

[2P-080]Microglia, a key player in hippocampal synaptic plasticity and memory deficits associated with sleep deprivation

*Katherine Picard^1,2, Janine Kox⁶, Eva Šimončičová², Robbert Havekes⁶, Marie-Eve Tremblay^1,2,3,4,5 (1. Dept Med moléculaire, Univ Laval, Québec, Qc, Canada, 2. Division of Medical Sciences, Univ of Victoria, Victoria, BC, Canada, 3. Dept of Biochemistry and Molecular Biology, Univ of British Columbia, Vancouver, BC, Canada, 4. Dept of Neurology and Neurosurgery, McGill Univ, Montréal, QC, Canada, 5. Centre for Advanced Materials and Related Technology (CAMTEC), Univ of Victoria, Victoria, BC, Canada, 6. Neurobiology expertise group, Groningen Institute for Evolutionary Life Sciences, Univ of Groningen, Groningen, The Netherlands)

[2P-081]Fibulin-7, an extracellular matrix protein, positively regulates oligodendrocyte differentiation and attachment to neuronal axons

*Momona Yamada¹, Miho Iwase¹, Chikako Hayashi¹, Susana de Vega², Nobuharu Suzuki¹ (1. Dept. of Mol. and Cell. Biol., Grad. Sch. of Med. and Dent. Sci., Tokyo Medical and Dental University, 2. Dept. of Med. for Orthop. and Motor Organ, Juntendo University Grad. Sch. of Med.)

[2P-082]The importance of the paranodal axoglial junctions in Purkinje axonal homeostasis

*Tomoko Ishibashi¹, Akitaka Shimura¹, Kota Sugawara¹, Hiroko Baba² (1. Dept of Mol Neurobiol, Tokyo Univ of Pharm and Life Sciences, 2. Dept of Occupational Therapy, Faculty of Rehabilitation, Niigata Univ of Health and Welfare)

[2P-083]The molecular function of the actin cytoskeletal regulator Arpc1a in proliferation and morphogenesis of oligodendrocyte-lineage cells

*Miho Iwase¹, Momona Yamada¹, Chikako Hayashi¹, Nobuharu Suzuki¹ (1. Dept. of Mol. and Cell Biol., Grad. Sch. of Med. and Dent. Sci., Tokyo Medical and Dental University)

[2P-084]Usability of human immortalized cell-based blood-brain barrier spheroid model for evaluation of macromolecular drug permeability via receptor-mediated transcytosis

*Hanae Morio¹, Keita Kitamura^1,2, Ayaka Okamoto¹, Ryo Ito³, Yoshiyuki Yamaura⁴, Takafumi Komori⁵, Tomomi Furihata¹ (1. Lab. Clin. Pharm. & Exp. Therap., Sch. Pharmacy., Tokyo Univ. Pharm. & Life Sci., 2. Lab. DDS Design & Drug Dispos., Grad. Sch. Pharm. Sci., Chiba Univ., 3. Res. Ctr. Neurol., Ono Pharm. Co., Ltd., 4. Dept. Pharmacokinet. Res., Ono Pharm. Co., Ltd., 5. Dept. Drug Metab. & Pharmacokinet., Eisai Co. Ltd.)

[2P-085]LYMPHATIC ENDOTHELIAL CELLS AFTER ISCHEMIC STROKE

*Kuwata Yasuhiro¹, Maki Takakuni¹, Yasuda Ken¹, Takayama Naoki¹, Toda Shintaro¹, Takahashi Ryosuke¹ (1. Department of Neurology, Kyoto University Graduate School of Medicine)

[2P-086]The quantitative analysis of immediate early genes regulation in neuron

*Kaho Itoh¹, Mariko Okada¹ (1. Institute for Protein Research, Osaka University)

[2P-087]Development of adeno-associated viral vector-optimized inhibitory neuron-specific promoters

*Yuuki Fukai¹, Ayumu Konno^1,2, Yasunori Matsuzaki^1,2, Hirokazu Hirai^1,2 (1. Department of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, 2. Viral Vector Core, Gunma University Initiative for Advanced Research (GIAR))

[2P-088]Neuronal activity-dependent SRF target gene expression via nuclear translocation of the SRF coactivator MRTFB

*Daisuke Ihara¹, Hiroki Tanabe¹, Shiori Imanishi¹, Aya Kosaka¹, Yukari Sano¹, Hiroyuki Sakagami², Akiko Tabuchi¹ (1. Lab Mol Neurobiol, Grad Sch of Med & Pharm Sci, Univ of Toyama, 2. Dept of Anatomy, Kitasato Univ Sch of Med)

[2P-089]Visualization of Protocadherin neuronal self-recognition code

*Ryosuke Kaneko¹, Manabu Abe², Yukiko Ueno Inoue³, Yusuke Takatsuru⁴, Masahiko Watanabe⁵, Kenji Sakimura², Yuchio Yanagawa⁶, Takeshi Yagi¹ (1. FBS, Osaka Univ, Osaka, Japan, 2. BRI, Niigata Univ, Niigata, Japan, 3. Dep of Biochem and Cellular Biol, National Institute of Neurosci, Tokyo, Japan, 4. Toyo Univ, Dept Nutr Health Sci, Gunma, Japan, 5. Grad Sch Med, Hokkaido Univ, Hokkaido, Japan, 6. Grad Sch Med, Gunma Univ, Gunma, Japan)

[2P-090]Knockdown of PSD95 and FXR1 inhibits protrusion formation

*Hideo Shimizu¹, Hirohiko Hohjoh¹ (1. Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry)

[2P-091]The m6A reader YTHDF1 modulates APC and controls axon and dendrite development.

*Loic Broix¹, Rohini Roy^2,1, Shengqun Hou^1,2, Momoe Sukegawa^1,2, Hidenori Ito³, Koh-ichi Nagata³, Dan Ohtan Wang^1,2 (1. RIKEN Center for Biosystems Dynamics Research (BDR), Kobe, Japan, 2. Graduate School of Biostudies, Kyoto University, Yoshida hon-machi, Kyoto, Japan, 3. Institute for developmental Research, Aichi Developmental Disability Center, Japan)

[2P-092]A cartographic and morphometric analysis of neuronal spines in m6A reader-deficient mice

*SHENGQUN HOU^1,2, Momoe Sukegawa^1,2, Dan Ohtan Wang^1,2 (1. RIKEN BDR, Kobe, Japan, 2. Grad Sch Biostudies, Univ of Kyoto, Kyoto, Japan)

[2P-093]SARS-CoV-2 Orf9b and its derived peptide suppress Par-1/MARK activity in neurons

*Taro Saito¹, Toshiya Oba¹, Kanae Ando¹ (1. Grad Sch Sci, Tokyo Met Univ, Tokyo, Japan)

[2P-094]Role of clustered protocadherin gamma for the specific synaptic connections between excitatory and parvalbumin-positive inhibitory neurons in the mouse visual cortex

*Kawamura Nanami¹, Tarusawa Etsuko¹, Yoshimura Yumiko², Yagi Takeshi¹ (1. Osaka Univ. FBS, Osaka, 2. Dept. Dev. Physiol., NIPS, Okazaki, Japan)

[2P-095]GABAergic neurons in the ventrolateral periaqueductal gray are implicated in cataplexy of narcoleptic mice.

*Sol Jeong¹, Shuntaro Uchida², Shingo Soya^1,2, Takeshi Sakurai^1,2 (1. Fac of Med, Univ of Tsukuba, Ibaraki, Japan, 2. WPI-IIIS, Ibaraki, Japan)

[2P-096]Morphological analysis of GABAergic neurons in the mouse claustrum.

*Megumu Takahashi^1,2,3, Kobayashi Tomoyo^2,3, Shinichiro Okamoto^2,3, Kenta Yamauchi^2,3, Kazuki Okamoto^2,3, Masato Koike², Tadashi Isa¹, Hiroyuki Hioki^2,3 (1. Dept Neurosci, Kyoto Univ, Grad Sch Med, 2. Dept Cell Biol Neurosci, Juntendo Univ, Grad Sch Med, 3. Dept Neuroanat, Juntendo Univ, Grad Sch Med)

[2P-097]Synaptic responses of striatal projection neurons to cortical repetitive stimulation are difference between direct and indirect pathway.

*Atsushi Tamura¹, Tomoki Sueoka¹, Masato Sasagawa⁴, Ryo Inagaki¹, Kazuto Kobayashi², Makoto Osanai^1,3,4 (1. Osaka Univ, Grad Sch Medicine, Suita, Japan, 2. Inst Biomed Sci, Fukushima Med Univ, Sch Med, Fukushima, Japan, 3. CiNet, NICT, Suita, Japan, 4. Grad Sch Med, Tohoku Univ, Sendai, Japan)

[2P-098]Direct hippocampo-presubicular projections in the common marmoset.

*Yoshiko Honda¹, Tetsuya Shimokawa², Seiji Matsuda², Yasushi Kobayashi³, Keiko Moriya-Ito⁴ (1. Dept Anat & Neurobiol, Sch Med, Tokyo Women’s Med, Univ, Tokyo, Japan, 2. Div Anat & Embryol, Dept Funct Biomed, Ehime Univ, Toon, Japan, 3. Dept Anat & Neurobiol, National Defense Med Col, Tokorozawa, Japan, 4. Dept Brain Development & Neural Regeneration, Tokyo Metropol Inst Med Sci, Tokyo, Japan)

[2P-099]Effects of GAK inhibition on Neurite Outgrowth and Synapse Formation

*Jun Egawa¹, Reza Arta¹, Michihiro Igarashi¹, Vance Lemmon², John Bixby², Melissa Barrero², Yan Shi², Toshiyuki Someya¹ (1. Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, 2. University of Miami, Miami, USA.)

[2P-100]Cholinergic induction of synchronous oscillation in the slug neuronal network in vitro.

*Suguru Kobayashi^1,2, Futori Riho¹ (1. Kagawa Schl Pharmaceut Sci, Tokushima Bunri Univ, Sanuki, Japan, 2. Inst Neurosci, Tokushima Bunri Univ, Sanuki, Japan)

[2P-101]Changes of c-Jun/c-Fos and CREB/ATF2 proteins after rat facial nerve axotomy

*Takashi Ishijima¹, Kazuyuki Nakajima¹ (1. Glycan & Life Systems Integration Center (GaLSIC), Soka University)

[2P-102]Modulation of action potential propagation and synaptic outputs by cAMP in cerebellar Purkinje cell axons

*Kei Furukawa¹, Shin-ya Kawaguchi¹ (1. Department of Biophysics, Graduate School of Science, Kyoto University)

[2P-103]The relationship between ribosomes and actin filament associated with local protein synthesis in axonal growth cones

*Osamu Hoshi¹, Nobuyuki Takei² (1. Tokyo Medical and Dental University, 2. Brain Research Institute, Niigata University)

[2P-104]Effects of fingolimod on vasculature and glial scar formation after closed-head injury

*Nitin Shrikant Sawant¹, Natsuki Okazaki¹, Mitsuhiro Morita¹ (1. Graduate School of Science, Kobe University, Kobe, Japan)

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