Session Details
[HT-04]Hot Topics 04 Clinical and molecular pathology of TDP-43 proteinopathies
Fri. May 23, 2025 8:00 AM - 10:00 AM JST
Fri. May 23, 2025 11:00 PM - 1:00 AM UTC
Fri. May 23, 2025 11:00 PM - 1:00 AM UTC
第05会場(大阪国際会議場10F 会議室1009)
Chairs: Masaki Takao（National Center of Neurology and Psychiatry (NCNP), Japan）, Yuko Saito（Tokyo Metropolitan Instite of Gerriatorics and Gelontology, Japan）
Nominal supported by: The Japanese society of Neuropathology
Among the neurodegenerative diseases caused by protein accumulation, we will focus on TDP43 proteinopathy. Like other diseases, degeneration caused by this protein is pathologically diverse, including clinical and ultrastructural features. However, the way it is transmitted by inoculation into animals is different from other proteins. Even when looking at ALS alone, the state of accumulation in upper and lower motor neurons is also different. In this symposium, we will present the latest findings on the neuropathology, molecular pathology, and clinical features of this protein-related disease.
[HT-04-1]Overview of neuropathology of TDP-43 proteinopathies - focusing on LATE neuropathologic change -
Tomoko Miki1,2 (1.Department of Neuropathology, Pitie-Salpetriere Hospital, AP-HP, France, 2.Department of Neurology, National Hospital Organization Minami-Okayama Medical Center, Japan)
Education:
2008 M.D. Nagasaki University Medical School
2020 Ph.D. (Dr. of Medical Science) Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Professional experience:
2008-2010: Resident, National Hospital Organization Iwakuni Clinical Center
2010-2011: Psychiatric Resident, Department of Neuropsychiatry, Okayama University Hospital
2011-2013: Psychiatric Resident, Mifune Hospital
2013-2023: Medical staff, Kinoko Espoir Hospital
2023-2024: Assistant Professor, Department of Neuropsychiatry, Okayama University Hospital
2024-present: Practitioner researcher associated in hospital clinical research, Department of Neuropathology, Pitie-Salpetriere Hospital, AP-HP
2008 M.D. Nagasaki University Medical School
2020 Ph.D. (Dr. of Medical Science) Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences
Professional experience:
2008-2010: Resident, National Hospital Organization Iwakuni Clinical Center
2010-2011: Psychiatric Resident, Department of Neuropsychiatry, Okayama University Hospital
2011-2013: Psychiatric Resident, Mifune Hospital
2013-2023: Medical staff, Kinoko Espoir Hospital
2023-2024: Assistant Professor, Department of Neuropsychiatry, Okayama University Hospital
2024-present: Practitioner researcher associated in hospital clinical research, Department of Neuropathology, Pitie-Salpetriere Hospital, AP-HP
[HT-04-2]Structural and biochemical classification of pathological TDP-43 extracted from FTLD-TDP brains
Airi Tarutani (Tokyo Metropolitan Institute of Medical Science, Japan)
Airi Tarutani is a researcher in Tokyo Metropolitan Institute of Medical Sciences. She holds a Ph.D. in Science from Tokyo Metropolitan University and worked at Tokyo Metropolitan Institute of Medical Science and the University of Tokyo, University Medical Center Göttingen as a postdoctoral fellow. Her work focuses on the structural and biochemical properties of tau, α-synuclein and TDP-43 extracted from human brains, and prion-like behaviors of these pathogenic proteins.
[HT-04-3]Clinical and pathological findings of ALS
Tomoyasu Matsubara1, Yuishin Izumi1, Shigeo Murayama2,3, Yuko Saito2 (1.Department of Neurology, Tokushima University Hospital, Japan, 2.Department of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Japan, 3.The Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Graduate School of Medicine, Osaka University, Japan)
Education
Mar 2011 MD, Hiroshima University, School of Medicine
Mar 2022 PhD, Hiroshima University, Graduate School of Biomedical Sciences
Professional Experience
2011-2013 Resident, Aso Iizuka Hospital, Fukuoka, Japan
2014-2017 Clinical and Research Fellow in Neurology, Hiroshima University, School of Medicine, Hiroshima, Japan
2017-2023 Research Fellow in Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan
2023- Designated Assistant Professor in Neurology, Tokushima University Hospital, Tokushima, Japan
Mar 2011 MD, Hiroshima University, School of Medicine
Mar 2022 PhD, Hiroshima University, Graduate School of Biomedical Sciences
Professional Experience
2011-2013 Resident, Aso Iizuka Hospital, Fukuoka, Japan
2014-2017 Clinical and Research Fellow in Neurology, Hiroshima University, School of Medicine, Hiroshima, Japan
2017-2023 Research Fellow in Neuropathology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan
2023- Designated Assistant Professor in Neurology, Tokushima University Hospital, Tokushima, Japan
[HT-04-4]Clinical and pathological characteristics of TDP-43 type C
Goichi Beck (Department of Neurology, Osaka University Graduate School of Medicine, Japan)
1996 - 2002, Faculty of Medicine, Osaka University
2007 - 2012, Osaka University Graduate School of Medicine
2012 - 2015, Department of Neurology, Osaka University Hospital
2015 - 2016, Department of Neurology, Toyonaka Municipal Hospital
2016 - 2019, Yerkes National Primate Research Center, Emory University
2019 - present, Department of Neurology, Osaka University Graduate School of Medicine
2007 - 2012, Osaka University Graduate School of Medicine
2012 - 2015, Department of Neurology, Osaka University Hospital
2015 - 2016, Department of Neurology, Toyonaka Municipal Hospital
2016 - 2019, Yerkes National Primate Research Center, Emory University
2019 - present, Department of Neurology, Osaka University Graduate School of Medicine