66th Annual Meeting of the Japanese Society of Neurology
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Session Details

Oral Session

[O-39]Oral Session 39　Dementia 5

Sat. May 24, 2025 10:30 AM - 12:00 PM JST
Sat. May 24, 2025 1:30 AM - 3:00 AM UTC
第03会場(大阪国際会議場10F 会議室1003)
Chairs: Yasumasa Ohyagi（Department of Neurology and Geriatric Medicine, Ehime University, Japan）, Kazuya Goto（Department of Regulation of Neurocognitive Disorders, Graduate School of Medicine, Kyoto University, Japan）

[O-39-1]Apolipoprotein E aggregation in microglial lysosome induces amyloid pathology in Alzheimer's disease

Seiji Kaji, Stefan Berghoff, Lena Spieth, Mikael Simons (Technical University of Munich, Germany)

[O-39-2]Oligomeric Tau Degradation by Autophagy

Tadanori Hamano1, Rei Asano1, Hirohito Sasaki1, Kanaan Nicholas2, Shigeo Murayama3, Maho Morishima3, Hironobu Naiki4, Shui-hui Yen5, Koji Aoki6, Yuki Kitazaki1, Tomohisa Yamaguchi1, Yoshinori Endo1, Soichi Enomoto1, Yasunari Nakamoto7 (1.Department of Neurology, University of Fukui, Japan, 2.Michigan State University, USA, 3.Brain Bank for Aging Research, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Japan, 4.Department of Molecular Pathology, University of Fukui, Japan, 5.Mayo Clinic Jacksonville, USA, 6.Department of Pharmacology, University of Fukui, Japan, 7.Department of Gastroenterology, University of Fukui, Japan)
1990年　福井医科大学卒業
1990年　福井医科大学第二内科研修医
1992年　名鉄病院神経内科
1995年　東京大学医学部脳研究部門脳病理学（井原康夫教授　国内留学）
1997年　福井医科大学大学院修了
2000年　福井医科大学第二内科助手
2004年　Mayo Clinic Jacksonville神経科学科　客員研究員
2006年　福井大学医学部第二内科講師
2013年　福井大学医学部第二内科准教授、神経内科診療科長

[O-39-3]Gene therapy with AD-protective genetic variant of the APP gene

Hiroki Sasaguri1, Sho Shimohama2, Jin Nakahara2, Tomohiro Hino3, Atsushi Hoshino3 (1.Dementia Pathophysiology Collaboration Unit, RIKEN Center for Brain Science, Japan, 2.Department of Neurology, Keio University School of Medicine, Japan, 3.Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan)

[O-39-4]Synaptotagmin1 directly regulates BACE1 protein expression levels via the lysosomal degradation

Takafumi Wada1, Motoki Akahori1, Chika Honjo1, Mizuki Matsumoto1, Sakiho Ueda1, Kazuya Goto2, Ryosuke Takahashi3, Riki Matsumoto1, Akira Kuzuya1 (1.Department of Neurology, Graduate School of Medicine, Kyoto University, Japan, 2.Department of Regulation of Neurocognitive Disorders, Graduate School of Medicine, Kyoto University, Japan, 3.Research Administration Center, Kyoto University, Japan)

[O-39-5]The genetic heterogeneity in AD contributes to concomitant clinical disorientation among the JP [Encore Presentation]

Makiko Taira1,2, Andrew J. Saykin3, Nobuo Fuse1,4 (1.Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Japan, 2.Department of Neurology, Neuroscience & Sensory Organs, Tohoku University Graduate of Medicine, Japan, 3.Center for Neuroimaging and Indiana Alzheimer's Disease Research Center, Indiana University, USA, 4.Advanced Research Center for Innovations in Next-Generation Medicine, Japan)

[O-39-6]AIM/CD5L promotes phagocytic removal of amyloid-beta thereby improving Alzheimer's disease

Natsumi Maehara, Satoko Arai, Toru Miyazaki (Department of Molecular Biomedicine for Pathogenesis, The Institute for AIM Medicine, Japan)
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