Session Details
[S-16]Symposium 16 Computational Neurology: understanding neurodegenerative diseases through mathematics and omics
Thu. May 22, 2025 8:00 AM - 9:30 AM JST
Thu. May 22, 2025 11:00 PM - 12:30 AM UTC
Thu. May 22, 2025 11:00 PM - 12:30 AM UTC
第07会場(大阪国際会議場12F 特別会議場)
Chairs: Koji Yamanaka（RIeM, Nagoya University, Japan）, Yuichiro Yada（Graduate school of medicine, Nagoya University, Japan）
Recent advances in mathematical and transcriptomic approaches have led to unexpected breakthroughs in neuroscience and neurological research. This symposium will present the latest applications of mathematical and omics analysis in basic and clinical neurologyl research and discuss future prospects.
[S-16-1]Data-driven modeling of neurodegenerative disease progression and its applications
Yuichiro Yada1, Naoki Honda1,2,3 (1.Laboratory for Data-driven Biology, Nagoya University Graduate School of Medicine, Japan, 2.Center for One Medicine Innovative Translational Research (COMIT), Nagoya University, Japan, 3.Laboratory of Data-driven Biology, Graduate School of Integrated Sciences for Life, Hiroshima University, Japan)
Dr. Yuichiro Yada is a designated lecturer at the Laboratory of Data-driven Biology, Nagoya University Graduate School of Medicine. He obtained B.S., M.Sc. and Ph.D. from the University of Tokyo in 2012, 2014, and 2017, respectively. His research focuses on computational approaches to neurological disease research applying the techniques of statistical modeling and machine learning.
[S-16-2]Computational models toward novel biological mechanisms of tau spread in Alzheimer's disease
Jacob W. Vogel (Department of Clinical Science Malmö, SciLifeLab, Lund University, Sweden)
Dr. Jacob Vogel is an Assistant Professor at Department of Clinical Sciences Malmö, SciLifeLab, Lund University (Sweden), supported by the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. Dr. Vogel’s training involved a PhD at McGill University with Dr. Alan Evans, and a postdoctoral fellowship at the University of Pennsylvania with Dr. Theodore Satterthwaite.
Dr. Vogel applies computational and statistical modeling approaches to human imaging and multiomic data to better understand the genesis and progression of neurodegenerative diseases. A major focus of Dr. Vogel’s work involves characterization of individual differences in disease expression. Dr. Vogel also has a keen interest in understanding what factors contribute to selective vulnerability (or resilience) of brain tissue to certain pathologies. Many of these research pursuits are achieved through the wrangling, aggregation and fusion of large datasets, with a focus on reproducibility and synthesis of complementary information. Dr. Vogel is best known for his work describing the distribution and spread of tau pathology in Alzhiemer's disease, and how these phenomena vary across the Alzheimer's disease population.
Dr. Vogel applies computational and statistical modeling approaches to human imaging and multiomic data to better understand the genesis and progression of neurodegenerative diseases. A major focus of Dr. Vogel’s work involves characterization of individual differences in disease expression. Dr. Vogel also has a keen interest in understanding what factors contribute to selective vulnerability (or resilience) of brain tissue to certain pathologies. Many of these research pursuits are achieved through the wrangling, aggregation and fusion of large datasets, with a focus on reproducibility and synthesis of complementary information. Dr. Vogel is best known for his work describing the distribution and spread of tau pathology in Alzhiemer's disease, and how these phenomena vary across the Alzheimer's disease population.
[S-16-3]Connectome-Based Modeling of Neurodegenerative Diseases: Strengths, Challenges, and E-I Balance
Hirohisa Watanabe, Kazuya Kawabata (Department of Neurology, Fujita Health University, School of Medicine, Japan)
Dr. Hirohisa Watanabe is currently a Professor and Chairperson of the Department of Neurology at Fujita Health University School of Medicine. He graduated from Mie University School of Medicine in 1993, received his neurological training at Nagoya Daini Red Cross Hospital and Nagoya University Hospital, and was certified as a neurologist by the Japanese Society of Neurology. As a designated professor, he intensively investigated the relationship between brain network changes and aging and neurodegenerative diseases at the Brain and Mind Research Center, Nagoya University. His research aims to develop biomarkers for early diagnosis and treatment of Parkinson's disease, multiple system atrophy, and neurodegenerative dementia.
[S-16-4]Spatial Transcriptome Analysis in Alzheimer's disease model mice
Okiru Komine1, Ryosaku Ota2, Yuichiro Yada2, Akira Sobue1, Yasuyoshi Oka3, Tomoo Ogi3,6, Takashi Saito4, Takaomi Saido5, Naoki Honda2,6,7, Koji Yamanaka1,6 (1.Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Japan, 2.Laboratory for Data-driven Biology, Nagoya University Graduate School of Medicine, Japan, 3.Department of Genetics, Research Institute of Environmental Medicine, Nagoya University, Japan, 4.Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Science, Japan, 5.Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Japan, 6.Center for One Mendicinennovative Translational Research (COMIT), Nagoya University, Japan, 7.Laboratory for Data-driven Biology, Graduate School of Integrated Science for Life, Hiroshima University, Japan)
Dr. Okiru Komine is a lecturer at the Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University. He obtained B.S. and M.Sc. from Tokyo University of Science in 2001 and 2003. He received Ph.D. from Tokyo Medical and Dental University in 2007. His major research area is neuroinflammation in neurodegenerative diseases, such as Amyotrophic lateral sclerosis and Alzheimer’s disease.