セッション詳細
[S-16]シンポジウム16 Computational Neurology: understanding neurodegenerative diseases through mathematics and omics
2025年5月22日(木) 8:00 〜 9:30
第07会場(大阪国際会議場12F 特別会議場)
座長：山中 宏二（名古屋大学環境医学研究所 病態神経科学分野）, 矢田 祐一郎（名古屋大学大学院医学系研究科）
Recent advances in mathematical and transcriptomic approaches have led to unexpected breakthroughs in neuroscience and neurological research. This symposium will present the latest applications of mathematical and omics analysis in basic and clinical neurologyl research and discuss future prospects.
[S-16-1]神経変性疾患のデータ駆動数理モデリングとその応用
矢田 祐一郎1, 本田 直樹1,2,3 (1.名古屋大学 大学院医学系研究科 データ駆動生物学分野, 2.名古屋大学 One Medicine 創薬シーズ開発・育成研究教育拠点, 3.広島大学 大学院統合生命科学研究科 データ駆動生物学研究室)
Dr. Yuichiro Yada is a designated lecturer at the Laboratory of Data-driven Biology, Nagoya University Graduate School of Medicine. He obtained B.S., M.Sc. and Ph.D. from the University of Tokyo in 2012, 2014, and 2017, respectively. His research focuses on computational approaches to neurological disease research applying the techniques of statistical modeling and machine learning.
[S-16-2]Computational models toward novel biological mechanisms of tau spread in Alzheimer's disease
Jacob W. Vogel (Department of Clinical Science Malmö, SciLifeLab, Lund University)
Dr. Jacob Vogel is an Assistant Professor at Department of Clinical Sciences Malmö, SciLifeLab, Lund University (Sweden), supported by the SciLifeLab & Wallenberg National Program for Data-Driven Life Science. Dr. Vogel’s training involved a PhD at McGill University with Dr. Alan Evans, and a postdoctoral fellowship at the University of Pennsylvania with Dr. Theodore Satterthwaite.
Dr. Vogel applies computational and statistical modeling approaches to human imaging and multiomic data to better understand the genesis and progression of neurodegenerative diseases. A major focus of Dr. Vogel’s work involves characterization of individual differences in disease expression. Dr. Vogel also has a keen interest in understanding what factors contribute to selective vulnerability (or resilience) of brain tissue to certain pathologies. Many of these research pursuits are achieved through the wrangling, aggregation and fusion of large datasets, with a focus on reproducibility and synthesis of complementary information. Dr. Vogel is best known for his work describing the distribution and spread of tau pathology in Alzhiemer's disease, and how these phenomena vary across the Alzheimer's disease population.
Dr. Vogel applies computational and statistical modeling approaches to human imaging and multiomic data to better understand the genesis and progression of neurodegenerative diseases. A major focus of Dr. Vogel’s work involves characterization of individual differences in disease expression. Dr. Vogel also has a keen interest in understanding what factors contribute to selective vulnerability (or resilience) of brain tissue to certain pathologies. Many of these research pursuits are achieved through the wrangling, aggregation and fusion of large datasets, with a focus on reproducibility and synthesis of complementary information. Dr. Vogel is best known for his work describing the distribution and spread of tau pathology in Alzhiemer's disease, and how these phenomena vary across the Alzheimer's disease population.
[S-16-3]神経変性疾患のコネクトームベースモデリング：強み、課題、そして興奮-抑制バランス
渡辺 宏久, 川畑 和也 (藤田医科大学医学部 脳神経内科学)
Dr. Hirohisa Watanabe is currently a Professor and Chairperson of the Department of Neurology at Fujita Health University School of Medicine. He graduated from Mie University School of Medicine in 1993, received his neurological training at Nagoya Daini Red Cross Hospital and Nagoya University Hospital, and was certified as a neurologist by the Japanese Society of Neurology. As a designated professor, he intensively investigated the relationship between brain network changes and aging and neurodegenerative diseases at the Brain and Mind Research Center, Nagoya University. His research aims to develop biomarkers for early diagnosis and treatment of Parkinson's disease, multiple system atrophy, and neurodegenerative dementia.
[S-16-4]アルツハイマー病モデルマウスにおける空間的遺伝子発現解析
小峯 起1, 太田 亮作2, 矢田 祐一郎2, 祖父江 顕1, 岡 泰由3, 荻 朋男3,6, 齊藤 貴志4, 西道 隆臣5, 本田 直樹2,6,7, 山中 宏二1,6 (1.名古屋大学環境医学研究所 病態神経科学分野, 2.名古屋大学大学院医学系研究科 データ駆動生物学分野, 3.名古屋大学環境医学研究所 発生・遺伝分野, 4.名古屋市立大学大学院医学研究科脳神経科学研究所 認知症科学分野, 5.理研CBS神経老化制御研究チーム, 6.名古屋大学 One Medicine創薬シーズ開発・育成研究教育拠点, 7.広島大学大学院統合生命科学研究科 データ駆動生物学研究室)
Dr. Okiru Komine is a lecturer at the Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University. He obtained B.S. and M.Sc. from Tokyo University of Science in 2001 and 2003. He received Ph.D. from Tokyo Medical and Dental University in 2007. His major research area is neuroinflammation in neurodegenerative diseases, such as Amyotrophic lateral sclerosis and Alzheimer’s disease.