[4O09m-2] Neuroimmunity and Circadian Rhythms

[4O09m-2-1] Immune checkpoint molecule Tim3 regulates microglial function and the development of Alzheimer’s disease pathology

*Kimitoshi Kimura^1,2,3,4, Ayshwarya Subramanian^1,2,3,5, Zhuoran Yin^1,2,3,6, Ahad Khalilnezhad^1,2,3,5, Yufan Wu^1,2,3,5, Danyang He^1,2,3, Dennis J. Selkoe^1,2,3, Aviv Regev⁵, Mario L. Suvà^5,7, Oleg Butovsky^1,2,3, Vijay K. Kuchroo^1,2,3,5 (1. The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital and Harvard Medical School, Boston, MA, USA., 2. Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., 3. Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA., 4. Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan., 5. Broad Institute of MIT and Harvard, Cambridge, MA, USA., 6. Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., 7. Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.)

Keywords:

microglia,Tim3,Alzheimer's disease,MGnD

Password required to view